HEXAMETHYLENE-1,6-DIISOCYANATE

822-06-0


Hazard Summary

Please Note: The main sources of information for this fact sheet are the Hazardous Substances Data Bank (HSDB), a database of summaries of peer-reviewed literature, and the Registry of Toxic Effects of Chemical Substances (RTECS), a database of toxic effects that are not peer reviewed.

Environmental/Occupational Exposure

Assessing Personal Exposure

Health Hazard Information


Acute Effects:


Chronic Effects (Noncancer):


Reproductive/Developmental Effects:


Cancer Risk:

Physical Properties

Uses



Conversion Factors:
To convert from ppm to mg/m3: mg/m3 = (ppm) � (molecular weight of the compound)/(24.45). For hexamethylene-1,6-diisocyanate: 1 ppm = 6.9 mg/m3.

Health Data from Inhalation Exposure

Concentration (mg/m3)
Health numbersa
Regulatory, advisory numbersb
Reference
1,000.0


--
--
--
--
100.0



--
--
--
--
10.0
  • LC50 (mice) (30 mg/m3)

3
--
--
--
--
1.0



--
--
--
--
0.1

  • NIOSH advisory level (maximum 10 min) (0.14 mg/m3)
2
--
--
--
--
0.01

  • NIOSH advisory level (10-h workday) (0.035 mg/m3)
2


LC50 (Lethal Concentration50)--A calculated concentration of a chemical in air to which exposure for a specific length of time is expected to cause death in 50% of a defined experimental animal population.
NIOSH--National Institute of Occupational Safety and Health.

a Health numbers are toxicological numbers from animal testing or risk assessment values developed by EPA.
b Regulatory numbers are values that have been incorporated in Government regulations, while advisory numbers are nonregulatory values provided by the Government or other groups as advice.

References

  1. U.S. Department of Health and Human Services. Hazardous Substances Data Bank (HSDB, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  2. New Jersey Department of Health. Hazardous Substance Fact Sheet on Hexamethylene Diisocyanate, New Jersey Department of Health, Trenton, NJ. 1986.
  3. U.S. Department of Health and Human Services. Registry of Toxic Effects of Chemical Substances (RTECS, online database). National Toxicology Information Program, National Library of Medicine, Bethesda, MD. 1993.
  4. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS) on Hexamethylene-1,6-Diisocyanate. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, Cincinnati, OH. 1993.

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