NERVE AGENT ANTIDOTE

File: aaaad_02.txt
Page: 02
Total Pages: 4
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CANA) HAVE BEEN MANUFACTURED AND ARE AWAITING DOD RELEASE FOR
SHIPMENT TO THE DESERT SHIELD THEATER. DISTRIBUTION WILL BE
PRIORITIZED BY CENTCOM.
2.  IN ANTICIPATION OF CANA ARRIVAL. CENTAF SUPPLEV\ENT TO AFM
160-11 IS CONTAINED IN PARA 4. DEPLOYED MEDICAL FACILITIES
SHOULD REVIEW THESE GUIDELINES AND PLAN FOR DISTRIBUTION TO AND


PAGE 3 RHDIAAA6445 UNCLAS
TRAINING OF ALL SUPPORTED AF PERSONNEL. COMMANDERS SHOULD
BE PARTICULARLY ADVISED THAT CANA CONTAINS- A CONTROLLED SUBSTANCE BUT
THAT NO PROLONGED INCAPACITATION OR ADDICTION EXISTS WITH
ADMINISTRATION OF A SINGLE UNAUTHORIZED INJECTION. BECAUSE OF
ABUSE POTENTIAL, IT IS POSSIBLE THAT SOME AUTHORITIES WILL RESTRICT
CANA ISSUE TO PARAMEDICAL PERSONNEL.
3. SHOULD USCENTCOM//CC CHOOSE TO RESTRICT ISSUE FOR ALL COMPONENTS.
CANA AUTOINJECTORS SHOULD BE CONCENTRATED AT (CCP'S), CASUALITY
COLLECTION POINTS AND USED IN ACCORDANCE WITH EMERGENCY MEDICAL
TREATMENT OF NERVE AGENT CASUALTIES AT CENTAF CCP'S.
4. CENTAF SUPPLEMENT TO AFM 160-11:
A. ADD PARA Z-8.A. (3) : DIAZEPAM (CONVUSANT ANTIDOTE FOR NERVE
AGENTS - CANA) AMELIORATES OR PREVENTS THE DEVELOPMENT OF CONVULSIONS
AND BRAIN INJURY IN MODERATE TO SEVERE AGENT POISONING.
B. ADD PARA Z-8.B. (3): DIAZEPAM. A 10 MG INTRAMUSCULAR INJECTION
IN THE THIGH WILL PRODUCE SIGNIFICANT PLASMA LEVELS IN 10 MINUTES
AND REACH PEAK PLASMA CONCENTRATIONS IN HUMANS IN ABOUT ONE HOUR.
THE CONCENTRATIONS WILL THEN DECLINE OVER A PROLONGED PERIOD. ANTI-
CONVULSANT AND BRAIN-PROTECTIVE EFFECTS OCCUR WELL BEFORE HIGH PLASMA
CONCENTRATIONS ARE ATTAINED. RAPID ADMINISTRATION OF DIAZEPAM BY IM


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INJECTION AFTER SOMAN (GD) EXPOSURE GENERALLY PREVENTS SOMAN
CONVULSIONS WELL BEFORE HIGH DIAZEPAM PLASMA LEVELS ARE ATTAINED.
SEVERE NERVE AGENT TOXICITY MAY REQUIRE ADDITIONAL DOSES OF DIAZEPAM
TO CONTROL CONVULSIONS. ONE 10 MG DOSE (ONE CANA AUTOINJECTOR) MAY
BE GIVEN DURING BUDDY CARE. IF ADDITIONAL DIAZEPAM IS NEEDED TO
CONTROL CONVULSIONS, IT WILL BE ADMINISTERED BY MEDICAL PERSONNEL AT


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