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O 260502Z FEB 91 
FM JOINT STAFF WASHINGTON DC 
INFO RUEADWD/OCSA WASHINGTON DC 
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RUCQVAB/USCINCSOC INTEL OPS CEN MACDILL AFB FL 
RHEPAAB/TAC IDHS LANGLEY AFB VA//IDHS// 
RUFTAKA/USA INTEL CENTER HEIDELBERG GE 
RUFTAKC/UDITDUSAREUR HEIDELBERG GE 
RUDOGHA/USNMR SHAPE BE//SURVEY// 
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RHEPAAB/TAC IDHS LANGLEY AFB VA //INO/INF// 
RUCJBBA/USCENTCOM REAR MACDILL AFB FL//CCJ2// 
RUCJACC/USCINCCENT MACDILL AFB FL//J2// 
RUSNNOA/USCINCEUR VAIHINGEN GE 
RUEDBIA/CDR513THMIBDE FT MONMOUTH NJ 
RUAGAAA/CDR501STMIBDE SEOUL KOR//IABDK-PH// 
RUAGAAA/CDR524THMIBN SEOUL KOR//IABDK-CX-PC// 
RUAJMAB/FOSIF WESTPAC KAMI SEYA JA//CSG// 
RUEOADA/9TIS SHAW AFB SC//INO// 
RHIPAAA/USCINCCENT//CCJ2// 
RHIUFAA/USCENTAF FWD HQS ELEMENT//IN// 
RHCGSRB/COMUSARCENT//G2// 
RHHMBRA/COMUSNAVCENT//N2// 
RUWDGAA/COMUSMARCENT//G2 
BT 
CONTROLS 
 
 
SERIAL: (U) IIR 2 721 0063 91 
 
BODY 
PASS: (U) DIA FOR 2 ITF/JIC/OICC; DA FOR DAMI-FII-E; 
DIRAFMIC/AFMIC-CR/ST-I FOR      [b.6.]     
 
COUNTRY: (U) IRAQ (IZ); JAPAN (JA). 
 
SUBJ: IIR 2 721 0063 91/IRAQI-JAPANESE COOPERATION ON MYCOTOXIN 
RESEARCH "DESERT STORM" (U) 
 
WARNING: (U) THIS IS AN INFORMATION REPORT, NOT FINALLY EVALUATED 
INTELLIGENCE.   
 
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                        DEPARTMENT OF DEFENSE 
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DOI: (U) 841200. 
REQS: (U) T-8C2-2650-01-90. 
 
SOURCE:  
		[b.1.  sec 1.5(c)] 
 
 
 
SUMMARY:            THIS REPORT PROVIDES INFORMATION ON A STUDY OF 
IRAQI SOIL SAMPLES PERFORMED BY JAPANESE SCIENTISTS JOINTLY WITH AN 
IRAQI SCIENTIST FROM BASRA UNIVERSITY, BASRA, IRAQ, AT A JAPANESE 
UNIVERSITY LAB IN 1984.  INFORMATION ON MYCOTOXINS PRODUCED BY THE 
FUNGI ISOLATED FROM THESE SOIL SAMPLES IS INCLUDED.  ENCLOSURES. 
 
TEXT: 1.     IN MID-1984 AN ASSOCIATE-PROFESSOR, S.K. ((ABDULLAH)), 
FROM BASRA UNIVERSITY, BASRA, IRAQ, BROUGHT 20 SOIL SAMPLES FROM AN 
UNSPECIFIED DATE PLANTATION IN IRAQ TO A JAPANESE UNIVERSITY FOR A 
JOINT STUDY.  PROFESSOR ABDULLAH STAYED IN JAPAN FOR APPROXIMATELY 
THREE MONTHS STUDYING THESE SOIL SAMPLES IN COOPERATION WITH 
SEVERAL NOTED JAPANESE SCIENTISTS. 
2.     FIFTY-SIX MOLDS WERE ISOLATED FROM THE TWENTY SOIL SAMPLES. 
THE FUNGAL SPECIES IDENTIFIED WERE -- 
- ASPERGILLUS FLAVUS. 
- ASPERGILLUS CAESPITOSUS. 
- ASPERGILLUS FUMIGATUS. 
- EMERICELLA NIDULANS. 
- EMERICELLA VARIECOLOR. 
- EMERICELLA ACRISTATA. 
- CHAETOMIUM SPP. 
- ASCOMYCETES. 
- DEUTEROMYCETES. 
MANY OF THE MOLDS WERE FOUND TO BE TOXIGENIC.  THIN-LAYER 
CHROMATOGRAPHY ANALYSIS WAS USED TO CONFIRM THE PRODUCTIVITY OF THE 
FOLLOWING -- 
- AFLATOXIN. 
- STERIGMATOCYSTIN. 
- ASTELTOXIN. 
- VERRUCULOGEN. 
- FUMITREMORGIN. 
A NEW TOXIC METABOLITE, TENTATIVELY DESIGNATED AS EQ-1, WAS 
ISOLATED FROM AN EMERICELLA QUADRILINEATA STRAIN. 
3.     THE TOXIC EFFECTS OF THESE MYCOTOXINS WERE STUDIED AND THE 
FOLLOWING INDICATIONS WERE NOTED.  ASTELTOXIN ATTACKED THE CENTRAL 
NERVOUS SYTEMS AND SPECIFICALLY INHIBITED RESPIRATION. 
VERRUCULOGEN AND FUMITREMORGIN B ALSO ATTACKED THE CENTRAL NERVOUS 
SYSTEM CAUSING STRONG TREMORGENIC EFFECTS.  THE LD50 OF 
FUMITREMORGIN A IS 0.185 MG/KG IN MICE, BY INJECTION. 
4. (U) FINDINGS OF THE JOINT STUDY ARE CONTAINED IN THE DOCUMENT AT 
ENCLOSURE 1 (TO FOLLOW). 
5.     DR. S.K. ABDULLAH WAS AN ASSOCIATE-PROFESSOR FROM BASRA 
UNIVERSITY, BASRA, IRAQ.  HE WAS APPROXIMATELY 35 YEARS OLD AT THE 
TIME OF HIS VISIT TO JAPAN.  HE WAS A TOXICOLOGIST AND HE 
SPECIALIZED IN THE STUDY OF AQUATIC FUNGI, ALTHOUGH HE ASSISTED IN 
THIS JOINT STUDY OF SOIL FUNGI. 
 
COMMENTS: 1.     (FIELD COMMENT) - SINCE THE COMPLETION OF THIS 
STUDY, THERE HAS BEEN NO FURTHER CONTACT BETWEEN THE SCIENTISTS, OR 
THE UNIVERSITY, AND DR. ABDULLAH FROM IRAQ. 
2.   (SOURCE COMMENT)   - IT IS BELIEVED THAT FUMITREMORGIN COULD 
ARISE BY THE CONDENSATION OF TRYPTOPHAN AND PROLINE SINCE BOTH OF 
THESE AMINO ACIDS ARE EVIDENT IN ITS CHEMICAL CONSTRUCTION.  SOME 
EVIDENCE TO THIS EFFECT HAS BEEN OBTAINED BY FEEDING VARIETIES OF 
L-TRYPTOPHAN AND L-PROLINE TO CULTURES OF ASPERGILLUS FUMIGATUS. 
MEVALONIC ACID IS ALSO INCORPORATED INTO FUMITREMORGIN A IN SIMILAR 
EXPERIMENTS. 
3.  (SOURCE COMMENT) - AT THE TIME OF THIS STUDY, BASRA 
UNIVERSITY DID NOT POSSESS THE TECHNOLOGY, EQUIPMENT, OR EXPERTISE 
TO PERFORM THIS STUDY IN SUFFICIENT DETAIL OR WITH SUFFICIENT 
RELIABILITY. 
4.     (FIELD COMMENT) - THESE MYCOTOXINS NATURALLY OCCUR IN IRAQI 
SOIL AND MAY BE INCLUDED IN THE IRAQI BIOLOGICAL WARFARE PROGRAM. 
 
//IPSP: (U) PGW 2650//. 
//COMSOBJ: (U) 211//. 
ADMIN 
PROJ: (U) 264301. 
COLL: (U) WS. 
INSTR: (U) US NO. 
PREP: (U) ([b.2.] 
ENCL: (U) TO FOLLOW - 2 ENCLOSURES. 
1.   [b.4.] 
 
 
2. DOCUMENT - TRANSLATION OF ENCLOSURE 1, (U) 1 COPY, UNDATED, 3 
PAGES (U). 
ACQ: (U) [b.2.] 
DISSEM: (U) FIELD: NONE. 
SENT TO: DIA RTS-2B (W/ENCLS). 
WARNING: (U)  
 
DECL:OADR 
BT 
 
#1392 
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