REACTION RATES FOR PRIMARY 2 VACCINE SERIES

File: 092496_sep96_decls7_0008.txt
Page: 0008
Total Pages: 8

Subject: REACTION RATES FOR PRIMARY 2 VACCINE SERIES                     

Unit: OTSG        

Parent Organization: HSC         

Box ID: BX003204

Folder Title: INFO PAPER PENTAVALENT ABCDE BOTULINUM TOXOID                                                   

Document Number:          2

Folder SEQ  #:         19








                 Since 1970, almost IO)OOO    talfictions at the tomaid have
                 administered to recipients who. were subsequently observed to
                 adverse reactions,. The rate of moderate and severe local, reacti --
                 was 1.84 for the initial series at shots and 10,7% for boost
                 shots (Table. 1),    In addition* there was a low incidence
                 system* reactions (3.0%) for both the initial series -and
                 booster shots,      The systmia reaction were generally mLl
                 consisting -of favor-, tiredness, headache and muscle Pain
                 iz),    Systafto reactions were often ooneuxtent with


                 Moderate or movers systmic reactions and severe local reactions
                 are not anticipated and should be reported by tolophont to the CVC.
                 Drug service,

                 Z*oamswot the deamentod increase in-reactiona, now lots of toxold
                 were manufactured in 1971, but distribution at the original lot was
                 continued until 19$1, A recent report on a very limited study an
                 the reaetotenivity of the now lots af. totaid indicated that they
                 ar* -probably no less coacteganis than the previous lot (I) I

                 Noting the higher IAGidenas 09 local reaeticam following mubsequent
                 yearly boosters. than follodat izdtial, series shator it -was d
                 advisable to evaluate -the, no*& tar boosters bYL
                 antitoxin levels and to boost only vhaa movessury, This appres-ah
                 revealed that boosters    subse"@t to the first one are not
                 noasseary more frequently than at 2 year intervals &ad that many
                 of the&* boosters can be avoided. Prior to 1974f yearly boosters
                 vote routinely given,
                 Moderat* local reacti@    Include arythwa,, ad@ and lnduratice..
 -hours# than gradual I y subside
                 and should be gone at 48 or at the. most 72 hours. When a moderate
                 losill - rogation occurs t weduatiolk of the des* of "oh subsequent
                 JZS*Ction&Lto 0.23 ml has boon shown to alloviate the reaction
                 without impairing the antitoxin responses
                 Rarely,. an individual iny have a reaction-ihavacterised by a deepp
                 potaloss, noninil    torr subcutaneous induration that may persist
                 ter 3 to 4 vo*ks.      these rarely measure more than 2 to 3
                             in diumter and are aboarbsid without residue.








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Document 8 f:/Week-36/BX003204/INFO PAPER PENTAVALENT ABCDE BOTULINUM TOXOID/reaction rates for primary 2 vaccine series:0920961557127
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003204
Unit = OTSG
Parent Organization = HSC
Folder Title = INFO PAPER PENTAVALENT ABCDE BOTULINUM TOXOID
Folder Seq # = 19
Subject = REACTION RATES FOR PRIMARY 2 VACCINE SERIES
Document Seq # = 7
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 20-SEP-1996