MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL

File: 970101_sep96_decls37_0013.txt
Page: 0013
Total Pages: 23

Subject: MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL                     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003201

Folder Title: MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL                                                     

Document Number:       1001

Folder Seq  #:         31




                                         UNCLASSIFIED










           inferred from animal studies. Use requires pretesting for
           sensitivity to animal serum (and desensitization for those
           allergic), and disadvantages include rapid clearance by immune
           elimination, as well as theoretical risk of serum sickness.




                              STAPHYLOCOCCAL @OTOXIN B





              Staphylococcal enterotoxin B (SEB) is one of the several
           exotoxins produced by Staphylococcus aureus, causing food
           poisoning when ingested.

              A biological warfare attack with aerosol delivery of SEB to
           the respiratory tract produces a distinct syndrome causing
           significant morbidity and potential mortality.

              Clinical Features. The disease begins 1-6 hours after
           exposure with the sudden onset of fever, chills, headache,
           myalgia, and non-productive cough. In more severe cases,
           dyspnea and retrosternal chest pain may also be present.
           Fever, which may reach 103-106 degrees F, has lasted 2-5 days,
           cough may persist 1-4 weeks. In many patients, nausea, which
           may be severe, vomiting, and diarrhea will also occur.
           Physical findings are often more unremarkable. Conjunctival
           injection may be present, and in the most severe cases, signs
           of pulmonary edema would be expected. The chest x-ray is
           generally normal, but in severe cases, there will be increased
           interstitial markings, atelectasis, and possible overt
           pulmonary edema. in moderately severe laboratory exposures,
           lost duty time has been greater than 2 weeks, but, based upon
           animal data, it is anticipated that severe exposures will
           result in fatalities.



           DIAGNOSIS

              . I             story FindingA. Laboratory findings are

              elevated erythrocyte sedimentation rate.

              0                         . In foodborne SEB intoxication,
              favor and respiratory involvement are not seen, and
              gastrointestinal symptoms are prominent.



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                                          UNCLASSIFIED

Document 23 f:/Week-36/BX003201/MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL/medical defense against biological material:12249609313138
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003201
Unit = OTSG
Parent Organization = HSC
Folder Title = MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL
Folder Seq # = 31
Subject = MEDICAL DEFENSE AGAINST BIOLOGICAL MATERIAL
Document Seq # = 1001
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 24-DEC-1996