CONCENTRATION CHEM ENVIRONMENTAL MEDIA COVERED IN ANALYSIS

File: 970107_sep96_decls17_0010.txt
Page: 0010
Total Pages: 10

Subject: CONCENTRATION CHEM ENVIRONMENTAL MEDIA COVERED IN ANALYSIS      

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003205

Folder Title: EXPOSURE CALCULATIONS                                                                           

Document Number:          2

Folder Seq  #:         19






        (:c)mbinLno       Acrt:mst Chemicals @rid. F., t 1. v@
  I i--- pei-ierii I ,RISK*A'@t;l,':ITA147 I-eportc C@re@ent thtkt ,.kre specific to a
               che(wic6.l And rott-Le of exposure.        are riot rcymoinea aci,osil,
       icals, or across routes of exporure,      'rttis is because one can not kset.@me
        a given chemical will produce tpie same toxi-c effects by all i"cy@tter of
  @-vosLtre, Rnd different citemicals produce different ranges ol toxic

  In some situations, it is appeopriate -for the user to calculate such combined
  risks. @Many chemicals will produce the same toxic efl@t, r4pgpi@dlesir..cf ti-K.-.
  C..-XPOSLtre route. For chemicals that cause cancer by sQ,/eral routes of exposure,
  the CPMBINED RISK FROM ALL ROUTES may be moee infoemAti-.,6 than rOtAtf.%-Sperific
  risk estimates$ unless there is evidence that carcinogenic risks from different
  eoutes r-qflect different mechanisms of action.
  similarly', 'for rion-cancer, toxic effects, differences between routes may only
  affect toxic potency, which will be reflected in the use of rolite-specific
  Reference Doses. A COMBINED HAZARD INDEX toe all routes Of exposure may be
 ,Aore informative than rouie-specific nizaed indices in such cases.

 @@-Whon there is evidence that doing so would bo toxicologically appropriate, You
  should consider calculating an estimate of TOTAL carcinogenic risk for all
  carcinogenic Chemicals to Which Your POPLtiation:is exposed. Similarly,,a
  GLOBAL HAZARD INDEX is appropriate for a set of chemicals that he-.,a o-@rlaoping
  patterns of toxicity. RISK*ASSISTANT does not Automatically make such
  calculations, which should be preceded by careful consideration of the specific
  chemicals covered by the assessment.

 ]In generating estimates of the combined toxic And caecihogenic risks of
  different chemicals, it is also imoortaht to bear in mind that the risks of
  exposure to multiple chemicals are not necessarily additive. Risks may be less
ad to risks that are greater than would be
       icted by an additive model. Unfortunately, only very limited data are
  Av@ilablo on the risks of exposure to multiple chemicals.

  In Addition to consideriho the potential combined risks of the chemicals at a
  sitoo it is also important to identify those chemicals; routes of exposure,
  exposure scenaeios, and media that aee associated with the highest cancer risk
  and the greatest hazard indices. Such intoematioo will help in the selection
     the most effective strategies for alleviating those risks.

  THESE ARE THE NOTES, IF ANYO ENTERED BY THE USER DURING THIS ANALYSIS

     a


    0 Reforencws
          Integrated Risk Information System.

  .HEAST: Health Effects Assessment Summary Tables.

  .Konz,, J.; K. Lisi and E. Friebele. 1989. Exposure Factors Handbook. Us EPA,
  L,ffice of Health and Envirommontal Assotsmoiit. Washington, D.C.

   tXPOSUAE NAME: KUWATT.GROUNDWATER


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Document 10 f:/Week-36/BX003205/EXPOSURE CALCULATIONS/concentration chem environmental media covered i:01029715471618
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003205
Unit = OTSG
Parent Organization = HSC
Folder Title = EXPOSURE CALCULATIONS
Folder Seq # = 19
Subject = CONCENTRATION CHEM ENVIRONMENTAL MEDIA COVERED I
Document Seq # = 2
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997