GROUP I: Exploratory and Epidemiologic Research on Health, Rates of Diseases and
Death, and Possible Association with Risk Factors
Study title, focus highlighted Facilitya Funding Estimated References
agency completion
Health and Exposure Survey of VAMC East VA Complete Manuscript
Persian Gulf Veterans (general Orange in
health symptoms, CFS, MCS, preparation
exposures)
Gulf War and Vietnam Veterans Cancer VAMC Boston VA 9/99 None
Incidence Surveillance
A Controlled Epidemiological and King's DOD 6/99 None
Clinical Study into the Effect of College
Gulf War Service on Servicemen and School of
Women of the United Kingdom Armed Medicine, UK
Forces (general health symptoms,
CFS, psychiatric conditions,
neuropsychological outcomes,
respiratory function)
Epidemiological Studies of Persian Klemm DOD 1/99 None
Gulf War Illnesses, Persian Gulf Analysis
Women's Health Linkage Study Group, Inc.,
(general health symptoms, Washington,
reproductive outcomes, cancer, DC
psychological conditions)
Risk Factors Among U.S. Army WRAIR DOD and Complete Manuscript
Soldiers for Enrolling in the VA in
Department of Veterans Affairs Gulf preparation
War Registry (demographics, aptitude
test scores, hospitalizations,
self-reported health behaviors)
Epidemiological Study of Gulf War NHRC DOD 5/97 None
Veteran Registrants (risk factors
associated with enrollment in CCEP
or VA Registry)
The General Well-being of Gulf War WRAIR DOD Complete 245-247,
Era Service Personnel from the 272,340
States of Pennsylvania and Hawaii:
A Survey (general symptoms, PTSD,
and other psychological conditions)
Epidemiologic Studies of Morbidity NHRC DOD 6/97 None
among Gulf War Veterans: A Search
for Etiologic Agents and Risk
Factors-Study 6: A Comparison of
Nonfederal Hospitalization
Experience among Veterans in
California Who Have Separated from
Active Service, Persian Gulf War v.
Era Veterans
Epidemiologic Studies of Morbidity NHRC DOD Survey in None
among Gulf War Veterans: A Search OMB review
for Etiologic Agents and Risk
Factors-Study 5: Seabee mail survey
(chronic disease outcomes)
Epidemiologic Studies of Morbidity NHRC DOD Complete 33,75
among Gulf War Veterans: A Search
for Etiologic Agents and Risk
Factors-Study 2: A Comparative
Study of Hospitalizations Among
Active Duty Personnel Who
Participated in the Gulf War and
Similar Personnel Who Did Not
Disease Cluster in a Pennsylvania CDC and DHHS Phases 1,2 291
Air National Guard Unit (general Pennsylvania complete;
health symptoms, psychiatric Department of phase 3
outcomes, infectious diseases) Health analysis
ongoing
Health Assessment of Persian Gulf CDC and Iowa DHHS 1/97 Manuscript
Veterans from Iowa (CFS, FM, Department of submitted
psychological conditions, cognitive Public Health
dysfunction, reproductive outcomes)
CORE [Clinical and Epidemiology VAMC Portland VA 9/99 None
Research] Project, Portland
Environmental Hazards Research
Center: Environment, Veterans
Health, and the Gulf War Syndrome
(general health symptoms and
diseases, reproductive outcomes,
stress, psychological conditions)
Epidemiologic Studies of Morbidity NHRC DOD Complete 106
Among Gulf War Veterans: A Search
for Etiologic Agents and Risk
Factors-Study 1: A Study of
Symptoms among 1,500 Seabees
(general health symptoms, hand grip
strength, respiratory function)
National Health Survey of Persian EES VA Phase 1 None
Gulf Veterans (survey of general complete;
health status, examining general phase 2
health symptoms and diseases, ongoing,
reproductive outcomes, stress, 5/98
psychological conditions)
Mortality Follow-up Study of Persian EES VA Complete; 108
Gulf Veterans long-term
followup
ongoing
United States Military Casualty National DHHS Complete 85
Comparisons During the Persian Gulf Institute for
War Occupational
Safety and
Health
Comparative Mortality Among U.S. WRAIR DOD Complete 343
Military Personnel Worldwide During
Operations Desert Shield/Storm
Health and Psychosocial Readjustment University of DOD Complete 199-201
of Gulf War Veteran Women Michigan
Health of Persian Gulf War Veteran University of DOD 8/99 None
Women Michigan
Exploratory Data Analysis with the Naval DOD 9/97 None
CCEP Database Postgraduate
School, MO
Investigation of a Suspected WRAIR DOD Complete 41
Outbreak of an Unknown Disease among
Veterans of Operation Desert
Shield/Desert Storm, 123rd Army
Reserve Command (general health
symptoms, medical and psychological
conditions, laboratory screening)
Investigation of Symptomatic Illness Navy DOD Complete 10
in Naval Mobile Construction Environmental
Battalion 24, November 1993-February and
1994 (general health symptoms, Preventive
review of medical records) Medicine Unit
#2, Norfolk
VA
A Statistical Study Correlating the U.S. Army DOD Complete 72
Reported Cases of Gulf War Syndrome Research
to Battlefield Locations of Laboratory,
Afflicted U.S. Army Personnel During Aberdeen, MD
the Iraq-Kuwait War-Part I: Method
to Relate Troop Deployment and the
Reported Cases of Gulf War Syndrome
and Probable Incidence of Maladies
Defined by the ICD-9-CM (statistical
techniques)
GROUP II: Health Outcomes from Service in the Gulf War
Epidemiologic Studies of Morbidity NHRC DOD 9/97 None
among Gulf War Veterans: A Search
for Etiologic Agents and Risk
Factors-Study 4: Infertility and
Miscarriage in Gulf War Veterans
Feasibility of Investigating Whether March of DOD 6/98 None
There is a Relationship between Dimes,
Birth Defects and Service in the California
Gulf War (birth defects in children Birth Defects
of Gulf War veterans in California) Monitoring
Program
Suspected Increase of Birth Defects Mississippi DHHS Complete 195
and Health Problems among Children State
Born to Persian Gulf Veterans in Department of
Mississippi Health
Epidemiologic Studies of Morbidity NHRC DOD Complete 36
among Gulf War Veterans: A Search
for Etiologic Agents and Risk
Factors-Study 3: A Comparative
Study of Pregnancy Outcomes among
Gulf War Veterans and Other Active
Duty Personnel
Epidemiologic Studies of Morbidity NHRC DOD 6/97 None
Among Gulf War Veterans: A Search
for Etiologic Agents and Risk
Factors-Study 7: Prevalence of
Congenital Anomalies among Children
of Persian Gulf War Veterans
Investigation of Seminal Plasma University of DOD 9/2000 None
Hypersensitivity Reactions Cincinnati
(immunological analysis of semen) Medical
Science Center
Cutaneous Findings in Gulf War WRMC DOD Complete 123
Veterans (dermatological
evaluations)
Diarrhea in Persian Gulf Veterans: VAMC VA 1/2000 None
An Irritable Bowel-Like Disorder Gainesville
Chronic Gastrointestinal Illness in VAMC Boston VA Complete 238
Persian Gulf Veterans
Study of Mycoplasmal Infections in WRAIR DOD 8/97 None
Gulf War Veterans
Immunological Evaluation of Persian VAMC VA Complete None
Gulf Veterans Birmingham
The Symptomatic Persian Gulf VAMC VA 12/99 120
Veterans Protocol: An Analysis of Birmingham
Risk Factors with an Immunologic and
Neuropsychiatric Assessment
Assessment of Genomic Instability Armed Forces DOD 5/97 None
via Chromosome 7 Inversion Frequency Institute of
in a Gulf War Syndrome Cohort v. Pathology
Selected Control Groups (immunology)
Evaluation of Respiratory VAMC Boston VA 9/99 None
Dysfunction Among Gulf War Veterans
(Kuwait oil-well fire effects)
Portland Environmental Hazards VAMC Portland VA 9/99 None
Research Center: Environment,
Veterans Health and the Gulf War
Syndrome-Project II. Clinical and
Neuroendocrine Aspects of
Fibromyalgia
Musculoskeletal Symptoms in Gulf War VAMC Long VA 1/99 None
Syndrome Beach
Evaluation of Muscle Function in University of DOD 11/99 None
Persian Gulf Veterans (causes of Pennsylvania
chronic fatigue and muscle weakness)
Evaluation of Neuromuscular Symptoms Wilford Hall DOD Complete 2
in Veterans of the Persian Gulf War Medical
(neurological, neuromuscular, and Center, TX
psychiatric evaluations)
Fatigue in Persian Gulf University of DOD 7/98 None
Syndrome-Physiologic Mechanisms Texas
(physiology of muscle fatigue)
Initial Contact Interview with VAMC Mountain VA 3/97 231-236
Marine Reservists in Operation Home
Desert Storm and 3-year Followup
(stress and PTSD outcomes)
Neurobehavioral Aspects of Persian VAMC VA Complete 73
Gulf War Experiences: A Pilot Study Pittsburgh
(stress, neuro-physiological and
-psychological effects, PTSD
outcomes)
A Comparison of PTSD Symptomology VAMC Phoenix VA Complete 296
among Three Army Medical Units
Involved in ODS
Post-traumatic Stress Disorder Fort Hood DOD Complete 54
Symptoms and Precombat Sexual and Mental Health
Physical Abuse in Desert Storm Clinic, TX
Veterans (previous abuse, combat
exposure, and PTSD)
Combat Stress Diagnosis, PTSD WRAIR DOD 9/98 70,188
Prevention
Desert Storm Reunion Survey (stress, VAMC Boston VA Complete 335-338
PTSD outcomes)
Portland Environmental Hazards VAMC Portland VA 9/99 121
Research Center: Environment,
Veterans Health and the Gulf War
Syndrome-Project 1. Psychosocial,
Neuropsychological, and
Neurobehavioral Assessment (stress,
neuropsychological, PTSD outcomes)
Memory and Attention in PTSD VAMC New VA 9/98 317-319
(neuropsychological outcomes) Orleans
Neuropsychological Functioning in VAMC New VA Complete 317-319
Veterans (stress and PTSD outcomes) Orleans
Psychological Assessment of VAMC New VA 9/97 250-255 Operation Desert Storm Returnees Orleans (stress, general health symptoms, depression, and PTSD outcomes) Evaluation of Cognitive Functioning VAMC New VA Complete 254 In Persian Gulf Veterans Reporting Orleans War-related Health Problems (stress, neuropsychological and PTSD outcomes) Evaluation of Cognitive Functioning VAMC Boston VA 9/99 210,335-338 of Persian Gulf Veterans (stress, depression, general health symptoms, PTSD outcomes) MMPI-2 Profiles [Minnesota Wilford Hall DOD Complete 86 Multiphasic Personality Inventory, Medical version 2] of Symptomatic Persian Center, TX Gulf Veterans (psychological conditions) Female Gender and Other Potential VAMC Boston DOD 3/98 210,335-338 Predictors of Functional Health Status Among Persian Gulf Veterans (stress, MCS, PTSD outcomes) Physiological and Psychological VAMC East VA 3/97 None Assessments of Persian Gulf Veterans Orange (stress, viral/immunological, neurophysiological and neuropsychological assessments, CFS, MCS outcomes) Effects of Exertion and Chemical VAMC East VA 9/99 None Stress on Persian Gulf Veterans Orange/VA (CFS, MCS outcomes) Evaluation of Neurological VAMC Boston VA 9/99 None Functioning in Persian Gulf Veterans (stress, CFS, MCS, PTSD outcomes) Persian Gulf Illnesses: Preliminary Madigan Army DOD Complete 181 Neurological Impressions Medical (neurological evaluations) Center, WA Validity of Computerized Tests VAMC Boston VA 9/99 122,332 (assessment of neurophysiologic damage) Psychological and Neurobiological West Haven DOD 7/99 239,240 Consequences of Gulf War Experience VAMC (stress, PTSD outcomes) Neuropsychological Functioning in Boston DOD 6/99 None Persian Gulf War Era Veterans University (stress outcomes, cognitive Medical Campus impairments, and CNS damage) Dysregulation of the Stress Response Georgetown DOD 6/99 None in the Persian Gulf Syndrome (CFS, University FM, psychiatric outcomes, Medical Center abnormalities in neurohormones related to stress response) Acute and Long-Term Impact of Ft. Detrick DOD 9/98 None Deployment to Southwest Asia on the Physical and Mental Health of Soldiers and Their Families (stress outcomes) Stress Symptoms and Their Causal VAMC VA 12/96 None Attribution in Desert Storm Veterans Clarksburg Post-traumatic Stress Symptoms Among Army Medical DOD Complete 126 Soldiers Exposed to Combat in the Department, Persian Gulf (combat exposure, Bremerhaven, stress reactions) Germany An Exploration of Post-traumatic University of VA Complete 215 Stress Disorder in Reserve Forces South Florida Deployed During Desert Storm
Symptoms of Post-traumatic Stress WRAIR/DOD DOD Complete 152,153
Disorder Following Recovery of War
Dead (followup of PTSD symptoms over
time)
Psychological and War Stress Highland Drive VA Complete 197,204
Symptoms among Deployed and Medical
Non-deployed Reservists Following Center,
the Persian Gulf War (combat Pittsburgh
exposure, stress, PTSD, and
depression)
Unit-Based Intervention for Gulf War Highland Drive VA Complete 198,204
Soldiers Surviving a SCUD Missile Medical
Attack: Program Description and Center,
Preliminary Findings (combat Pittsburgh
exposure, PTSD, and depression)
Psychological Adjustment In VAMC VA Complete 237
Operation Desert Shield/Storm Gainesville
Veterans (stress outcomes)
GROUP III: Risk Factors and Gulf War Veterans' Health
Persian Gulf Veterans Health CHPPM DOD 12/97 None
Tracking System (Kuwait oil fire
smoke and other environmental
exposures)
Portland Environmental Hazards VAMC Portland, VA 9/99 116
Research Center: Environment, OR
Veterans Health, and the Gulf War
Syndrome-Project IV. DNA Damage
from Chemical Agents and Its Repair
(nitrogen mustard effects in human
skin cultures)
Chronic Organophosphorus Exposure University of DOD 5/98 None
and Cognition (chemical weapon Georgia
effects in lab. animals)
Carcinogenicity of Depleted Uranium ITRI DOD 10/98 None
Fragments
Health Risk Assessment of Embedded AFFRI DOD 9/97 None
Depleted Uranium: Behavior,
Physiology, Histology, and
Biokinetic Modeling
Kuwait Oil Fire Health Risk CHPPM DOD Complete 154,265
Assessment
Kuwait Oil Fires Troop Exposure CHPPM DOD 12/96 265
Assessment Model
The Aromatic Hydrocarbon Receptor VAMC Boston VA 9/99 None
AhR as a Biomarker of Susceptibility
(exposure to Kuwaiti oil well fires
and petroleum products)
Biomarkers of Susceptibility and NIH DHHS 1/97 265
Polycyclic Aromatic Hydrocarbon
(PAH) Exposure in Urine and Blood
Cell DNA from U.S. Army Soldiers
Exposed to Kuwaiti Oil Well Fires
Volatile Organic Compounds in the CDC DHHS Complete 55
Blood of Persons in Kuwait during
the Oil Fires
Characteristics of Emissions from ITRI DOD 7/98 none
Heaters Burning Leaded Diesel Fuel
in Unvented Tents
Forward Deployable Diagnostics for NMRI, WRAIR, DOD 9/2001 111,327
Infectious Diseases USAMRIID
Identification of the Genetic Army Research DOD 7/98 24,25
Factors Which Control Tropism in Lab, Brazil
Leishmania
Protective Immunity in Experimental VAMC San VA 9/97 None
Visceral Leishmaniasis Antonio
Vaccine-mediated Immunity Against VAMC Cleveland VA 9/99 81-83
Leishmaniasis
Development of a Leishmania Skin WRAIR DOD 1/2000 243,244
Test Antigen
Serologic Diagnosis of Viscerotropic WRAIR DOD Complete 45-47
Leishmaniasis
Diagnostic Antigens of Leishmania Infectious DOD 6/98 None
tropica Disease
Research
Institute,
Seattle
Assessment of the Health of Workers USAMRIID DOD 11/98 None
Formerly Employed at Ft. Detrick Who
Received Repeated Immunizations with
Multiple Vaccines-Study I
Anthrax and Botulinum Vaccines: USAMRIID DOD Complete 202b
Antibody Prevalence and Immune
Response to a Booster Dose in
Military Personnel Initially
Vaccinated During Desert
Shield/Desert Storm
Combat Stress Pharmacotherapy WRAIR DOD 9/99 79,80,206-20
9
Neurobehavioral and Immunological University of DOD 5/99 None
Toxicity of Pyridostigmine, Florida,
Permethrin and DEET in Males and Gainesville
Females (immune and neurobehavioral
effects of PB, DEET, and permethrin
in rats)
Effects of Genetics and Stress on VAMC East VA 9/97 196
Responses to Environmental Toxins Orange
(stress as a mediating factor for
effects of PB in rats)
Effects of PB in Flinders Line Rats University of DOD 7/98 None
Differing in Cholinergic Sensitivity North
(genetic effects in rats) Carolina,
Chapel Hill
Physiological and Neurobehavioral Tri-service DOD 10/97 180
Effects in Rodents from Exposure to Toxicology
Pyridostigmine, Fuels, and Consortium,
DEET-Toxicity of Simulated Persian Wright
Gulf War Exposure Patterson AFB
Possible Relationship Between WRAIR DOD 12/96 49,67,68
Multiple Chemical Sensitivity of
Insect Repellent DEET and Carbamate
Pyridostigmine in Gulf War Veterans'
Illnesses: Study of Variability in
Pyridostigmine Inhibition of Blood
Cholinesterases in Healthy Adults
(interactions of PB with various
pesticides in humans)
Pyridostigmine Synergistic Toxicity CHPPM DOD Complete 151,263
Study (interaction of PB and various
pesticides in humans)
Portland Environmental Hazards VAMC Portland, VA 9/99 50
Research Center: Environment, OR
Veterans Heath and the Gulf War
Syndrome-Project III. Neurotoxicity
of Environmental Pollutants and
Warfare Agents (effects of PB and
hydrocarbon solvents on rodent
nervous system)
Male/Female Differential Tolerances South Florida DOD Complete 128
to Pyridostigmine Bromide (humans) Drug Research
and Clinical
Research
Services
Retrospective Studies Involving USAMRMC DOD Complete 270
Military Use of Pyridostigmine as a
Pretreatment for Nerve Agent
Poisoning (humans)
Pyridostigmine Used as a Nerve Agent USAMRIC DOD Complete 110c
Pretreatment Under Wartime
Conditions (humans)
Effects of Persian Gulf War Service AFIP DOD 12/98 None
on Military Working Dogs
Use of Roster of Veterans Who Served EES, U.S. VA Complete None
in Persian Gulf Area Army, and the
Joint Services
Environmental
Support Group
b Considerable general vaccine research concerning botulinum and anthrax vaccines is ongoing. c Before and after the Gulf War, DOD has conducted research on PB in conjunction with IND 23,509.