Abdulla, F. A., E. Bradbury, et al., "Relationship Between Up-Regulation of Nicotine Binding Sites in Rat Brain and Delayed Cognitive Enhancement Observed After Chronic or Acute Nicotinic Receptor Simulation," Psychopharmacol, 124(4), 1996, pp. 323-331.

Abou-Donia, M., "Metabolism and Toxicokinetics of Xenobiotics," in Derelanko and Hollinger, eds., CRC Practical Handbook of Toxicology, Boca Raton, Fla.: CRC Press, 1995, pp. 282-289.

Abou-Donia, M., "Organophosphorus-Induced Delayed Neurotoxicity," Ann Rev Pharmacol Toxicol, 21, 1981, pp. 511-548.

Abou-Donia, M., personal communication, 1998.

Abou-Donia, M., and D. M. Lapadula, "Mechanisms of Organophosphorus Ester-Induced Delayed Neurotoxicity: Type I and Type II," Ann Rev Pharmacol Toxicol, 30, 1990, pp. 405-440.

Abou-Donia, M., and S. Preissig, "Delayed Neurotoxicity from Continuous Low-Dose Oral Administration of Leptophos in Hens," Toxicol Appl Pharmacol, 38, 1976, pp. 595-608.

Abou-Donia, M. B., A. A. Abdel-Rahman, et al., "Stress with Exposure to Pyridostigmine Bromide (PB), DEET, and Permethrin Increases Rat Blood-Brain Barrier (BBB) Permeability," FASEB Journal, 11(3), 1997, Abstract 3617.

Abou-Donia, M., K. Wilmarth, et al., "Increased Neurotoxicity Following Concurrent Exposure to Pyridostigmine Bromide (PB), Deet, and Chlorpyrifos," Fundam Appl Toxicol, 34, 1996a, pp. 201-222.

Abou-Donia, M., K. Wilmarth, et al., "Neurotoxicity Resulting from Coexposure to Pyridostigmine Bromide, DEET, and Permethrin: Implications of Gulf War Chemical Exposures," J of Toxicol and Environmental Health, 48, 1996b, pp. 35-56.

Abou-Donia, M., K. Wilmarth, et al., "Increased Neurotoxicity Following Simultaneous Exposure to Pyridostigmine Bromide (PB), Deet, and Chlorpyrifos," Joint Meeting of the American Society for Biochemistry and Molecular Biology, American Society for Investigative Pathology, and the American Association of Immunologists, FASEB Journal, 1996c.

Adler, M., D. Hinman, et al., "Role of Muscle Fasciculations in the Generation of Myopathies in Mammalian Skeletal Muscle," Brain Research Bulletin, 29, 1992, pp. 179-187.

Adler, M., D. Maxwell, et al., In Vivo and in Vitro Pathophysiology of Mammalian Skeletal Muscle Following Acute and Subacute Exposure to Pyridostigmine. Studies on Muscle Contractility and Cellular Mechanisms, Aberdeen Proving Ground, Md.: 4th Annual Chemical Defense Bioscience Review, 1984.

Adler, S., M. Lam, et al., A Pocket Manual of Differential Diagnosis, Boston: Little Brown and Company, 1994.

Agnati, L., M. Zoli, et al., "Intercellular Communication in the Brain: Wiring Versus Volume Transmission," Neuroscience, 69, 1995, p. 711.

Agnoli, A., N. Martucci, et al., "Effect of Cholinergic and Anticholinergic Drugs on Short Term Memory in Alzheimer's Dementia: A Neuropsychological and Computerized Electroencephalographic Study," Clin Neuropharmacol, 6, 1983, pp. 311-323.

Aiello-Malmberg, P., A. Bartolini, et al., "Effects of Morphine, Physostigmine and Raphe Nuclei Stimulation on 5-Hydroxytryptamine Release from the Cerebral Cortex of the Cat," Brit J Pharmacol, 65(4), 1979, pp. 547-555.

Akaike, A., S. Ikeda, et al., "The Nature of the Interactions of Pyridostigmine with the Nicotinic Acetylcholine Receptor-Ionic Channel Complex II. Patch Clamp Studies," Mol Pharmacol, 25, 1984, pp. 102-112.

Akiyama, N., K. Okumura, et al., "Altered Acetylcholine and Norepinephrine Concentrations in Diabetic Rat Hearts. Role of Parasympathetic Nervous System in Diabetic Cardiomyopathy," Diabetes, 38, 1989, pp. 231-236.

Albright, J., and R. Goldstein, "Is There Evidence of an Immunologic Basis for Multiple Chemical Sensitivity," Toxicol Ind Health, 8, 1992, pp. 215-219.

Albuquerque, E., "The Molecular Targets of Selected Organophosphorus Compounds at Nicotinic, Muscarinic, GABA, and Glutamate Synapses: Acute and Chronic Studies Including Prophylactic and Therapeutic Approaches," Fort Detrick, Md.: U.S. Army Medical Research and Development Command, 1985.

Albuquerque, E., M. Alkondon, et al., "Properties of Neuronal Nicotinic Acetylcholine Receptors: Pharmacological Characterization and Modulation of Synaptic Function," J Pharmacol Exp Therapeutics, 280(1-3), 1997, pp. 1117-1136.

Albuquerque, E., A. Boyne, et al., "Molecular and Behavioral Studies of Anticholinesterase Agents on Various Receptor Targets in the Peripheral and Central Nervous System: Acute and Chronic Studies Using Biophysical, Biochemical, Histological and Therapeutic Approaches," Fort Detrick, Md.: U.S. Army Medical Research and Development Command. Contract DAMD17-81-C-1279, 1983.

Albuquerque, E., A. Boyne, et al., "The Molecular Targets of Selected Organophosphorus Compounds at Nicotinic, Muscarinic, GABA, and Glutamate Synapses: Acute and Chronic Studies Using Biophysical, Biochemical, Histological and Therapeutic Approaches," Fort Detrick, Md.: U.S. Army Medical Research and Development Command, annual report, Contract DAMD17-81-C-1279, 1995.

Albuquerque, E., A. Costa, et al., "Functional Properties of the Nicotinic and Glutamatergic Receptors," J of Receptor Research, 11, 1991, pp. 1-4.

Albuquerque, E., S. Deshpande, et al., "Multiple Actions of Anticholinesterase Agents on Chemosensitive Synapses: Molecular Basis for Prophylaxis and Treatment of Organophosphate Poisoning," Fundam Appl Toxicol, 5, 1985, S182-S203.

Albuquerque, E., E. Pereira, et al., "Nicotinic Receptor Function in the Mammalian Central Nervous System," Ann NY Acad Sci, 757, 1995, pp. 48-72.

Albuquerque, E., E. Pereira, et al., "Nicotinic Acetylcholine Receptors on Hippocampal Neurons: Distribution on the Neuronal Surface and Modulation of Receptor Activity," J of Receptor and Signal Transduction Research, 17(1-3), 1997, pp. 243-266.

Alisoglu, R., J. Nagelhout, et al., "Reversal of Pipecuronium Bromide with Pyridostigmine," Clinical Forum for Nurse Anesthetists, 6(1), 1995, pp. 43-45.

al-Jafari, A. A., and M. A. Kamal, "The Preparation and Kinetic Analysis of Multiple Forms of Chicken Brain Acetylcholinesterase," Cell Biochem Funct, 12(1), 1994, pp. 29-35.

Alkondon, M., and E. Albuquerque, "Diversity of Nicotinic Acetylcholine Receptors in Rat Hippocampal Neurons. I. Pharmacological and Functional Evidence for Distinct Structural Subtypes," J Pharmacol Exp Therapeutics, 265(3), 1993, pp. 1455-1473.

Alkondon, M., E. Rocha, et al., "Diversity of Nicotinic Acetylcholine Receptors in Rat Brain V. Alpha Bungarotoxin-Sensitive Nicotinic Receptors in Olfactory Bulb Neurons and Presynaptic Modulation of Glutamate Release," J Pharmacol Exp Therapeutics, 278, 1996, pp. 1460-1471.

Allan, W., "Bromism and Iodism in Gulf War and Other Illness," Internet report,, accessed 1997.

Allen, C., and E. Albuquerque, "Conductance Properties of GABA-Activated Chloride Currents Recorded from Cultured Hippocampal Neurons," Brain Res, 410, 1987, pp. 159-163.

Alles, G., and R. Hawes, "Cholinesterases in the Blood of Man," J Biol Chem, 133, 1940, p. 375.

Almog, S., E. Winkler, et al., "Acute Pyridostigmine Overdose: A Report of Nine Cases," Isr J Med Sci, 27, 1991, pp. 659-663.

Altland, K., H. Goedde, et al., "New Biochemical and Immunological Data on Quantitative and Qualitative Variability of Human Pseudocholinesterase," Humangenetik, 14, 1971, pp. 56-60.

Amato, A., A. McVey, et al., "Evaluation of Neuromuscular Symptoms in Veterans of the Persian Gulf War," Neurology, 48, 1997, pp. 4-12.

American Hospital Formulary Service, "Pyridostigmine Bromide," in G. McEvoy, ed., AHFS Drug Information, Bethesda, Md.: American Society of Hospital Pharmacists, Inc., 1991, pp. 680-682.

Ames, R., K. Steenland, et al., "Chronic Neurologic Sequelae to Cholinesterase Inhibition Among Agricultural Pesticide Applicators," Archives of Environmental Health, 50(6), 1995, pp. 440-444.

Amr, M., M. Allam, et al., "Neurobehavioral Changes Among Workers in Some Chemical Industries in Egypt," Environ Res, 63, 1993, pp. 295-300.

Anderson, D., L. Harris, et al., "The Effect of Pyridostigmine Pretreatment on Oxime Efficacy Against Intoxication by Soman or VX in Rats," Drug Chem Toxicol, 15, 1992, pp. 285-294.

Anderson, R., W. Chamberlain, et al., "Decreased Tetanic Contracture of Rat Skeletal Muscle Induced by Pyridostigmine," J Toxicol Environ Health, 18, 1986, pp. 221-230.

Andres, C., R. Beeri, et al., "Cholinergic Drug Resistance and Impaired Learning in Transgenic Mice Overexpressing Brain Acetylcholinesterase," section in unclassified document, "Studies on the Molecular Dissection of the Human Cholinesterase Variants and their Genomic Origins," Jerusalem, Israel: Hebrew University, 1996.

Andres, C., R. Beeri, et al., "Cholinergic Drug Resistance and Impaired Spatial Learning in Transgenic Mice Overexpressing Human Brain Acetylcholinesterase," Prog Brain Res, 109, 1996, pp. 265-272.

Andres, C., et al., "Acetylcholinesterase-Transgenic Mice Display Embryonic Modulations in Spinal Cord Choline Acetyltransferase and Neurexin Ibeta Gene Expression Followed by Late-Onset Neuromotor Deterioration," Proc Natl Acad Sci USA, 94, 1997, pp. 8173-8178.

Antelman, S., "Time-Dependent Sensitization as the Cornerstone for a New Approach to Pharmacotherapy: Drugs as Foreign/Stressful Stimuli," Drug Devel Res, 14, 1988, pp. 1-30.

Antelman, S., A. Eichler, et al., "Interchangeability of Stress and Amphetamine in Sensitization," Science, 207, 1980, pp. 329-331.

Antelman, S., D. Kocan, et al., "One Brief Exposure to a Psychological Stressor Induces Long-Lasting, Time-Dependent Sensitization of Both the Cataleptic and Neurochemical Responses to Haloperidol," Life Sci, 51, 1992, pp. 261-266.

Antelman, S., S. Knopf, et al., "One Stressful Event Blocks Multiple Actions of Diazepam for at Least a Month," Brain Res, 445, 1988, pp. 380-385.

Antonini, G., S. Morino, et al., "Myasthenia Gravis in the Elderly: A Hospital Based Study," Acta Neurol Scand, 93, 1996, pp. 260-262.

Aquilonius, S., S. Eckernas, et al., "A Pharmacokinetic Study of Neostigmine in Man Using Gas Chromatography-Mass Spectrometry," Eur J Clin Pharmacol, 15(5), 1979, pp. 367-371.

Aquilonius, S., S. Eckernas, et al., "Pharmacokinetics and Oral Bioavailability of Pyridostigmine in Man," Eur J Clin Pharmacol, 18, 1980, pp. 428-432.

Aracava, Y., S. Deshpande, et al., "The Molecular Basis of Anticholinesterase Actions," Ann NY Acad Sci, 505, 1987, pp. 226-255.

Arad, M., A. Roth, et al., "Safety of Pyridostigmine in Hypertensive Patients Receiving Beta Blockers," The Am J Cardiology, 69, 1992, pp. 518-522.

Arad, M., R. Arnon, et al., "Effects of Heat-Exercise Stress, NBC Clothing, and Pyridostigmine Treatment on Psychomotor and Subjective Measures of Performance," Military Medicine, 157, 1992, pp. 210-214.

Araneta, M. R. G., C. A. Moore, et al., "Goldenhar Syndrome Among Infants Born in Military Hospitals to Gulf War Veterans," Teratology, 56, 1997, pp. 244-251.

Arendash, G. W., P. R. Sanberg, and G. J. Sengstock, "Nicotine Enhances the Learning and Memory of Aged Rats," Pharmacol Biochem Behav, 52(3), 1995, pp. 517-523.

Arendash, G. W., G. J. Sengstock, et al., "Improved Learning and Memory in Aged Rats with Chronic Administration of the Nicotinic Receptor Agonist GTS-21," Brain Res, 674(2), 1995, pp. 252-259.

Ariens, A., E. Meeter, et al., "Reversible Necrosis at the End-Plate Region in Striated Muscle of the Rat Poisoned with Cholinesterase Inhibitors," Experientia, 25, 1969, pp. 57-59.

Arvat, E., L. Gianotti, et al., "The Enhancing Effect of Pyridostigmine on the GH Response to GHRH Undergoes an Accelerated Age-Related Reduction in Down Syndrome," Dementia, 7, 1996, pp. 288-292.

sberg, M., "Monoamine Neurotransmitters in Human Aggressiveness and Violence: A Selective Review," Criminal Behaviour and Mental Health, 4, 1994, pp. 303-327.

Attia, A. M. M. H. Mostafa, et al., "Changes in Nocturnal Pineal Indoleamine Metabolism in Rats Treated with Parthion Are Prevented by Beta-Adrenergic Antagonist Administration," Toxicol, 97(1-3), 1995a, pp. 183-189.

Attia, A. M., M. H. Mostafa, et al., "Night-Time Rise in Rat Pineal N-Acetyltransferase Due to Carbaryl Administration is Reduced by Propranolol Treatment," Biomed and Environ Sci, 8(1), 1995b, pp. 45-53.

Augerson, W., "Chemical Casualty Treatment Protocol Development. Phase I: Treatment Approaches. Chapter 5: Nerve Agents," final report to Aerospace Medical Division, Air Force Systems Command, USAF, Arthur D. Little, Inc., 1986.

Augerson, W., A Review of the Scientific Literature As It Pertains to Gulf War Illnesses, Vol. 5: Chemical and Biological Warfare Agents, Santa Monica, Calif.: RAND, MR-1018/5, forthcoming.

Avlonitou, E., and R. Elizondo, "Effects of Atropine and Pyridostigmine in Heat-Stressed Patas Monkeys," Aviat Space Environ Med, 59, 1988, pp. 544-548.

Axelrod, B. N., and I. B. Milner, "Neuropsychological Findings in a Sample of Operation Desert Storm Veterans," J Neuropsychiatry Clin Neurosci, 9(1), 1997, pp. 23-28.

Bagchi, D., G. Bhattacharya, et al., "In Vitro and in Vivo Induction of Heat Shock (Stress) Protein (Hsp) Gene Expression by Selected Pesticides," Toxicology, 112, 1996, pp. 57-68.

Bajgar, J., "Biological Monitoring of Exposure to Nerve Agents," Brit J Industrial Medicine, 49, 1992, pp. 648-653.

Baker, D., and E. Sedgwick, "Single Fibre Electromyographic Changes in Man After Organophosphate Exposure," Hum & Exp Toxicol, 15(5), 1996, pp. 369-375.

Baker, E., "Organic Solvent Neurotoxicity," Ann Rev Public Health, 9, 1988, pp. 223-232.

Baldinger, S. L., and D. J. Schroeder, Nicotine Therapy in Patients with Alzheimer's Disease, Ann Pharmacother, 29(3), 1995, pp. 314-315.

Bames, J., and F. Denz, "Experimental Demyelination with Organophosphorus Compounds," J Pathol Bacteriol, 65, 1974, pp. 597-606.

Banks, W., and A. Kastin, "Aluminium Increases Permeability of the Blood-Brain Barrier to Labeled DSIP and Beta-Endorphin: Possible Implications for Senile and Dialysis Dementia," Lancet, 2, 1983, pp. 1237-1239.

Bannon, A. W., K. L. Gunther, et al., "Is Epibatidine Really Analgesic? Dissociation of the Activity, Temperature, and Analgesic Effects of (+/-)-Epibatidine," Pharmacol Biochem Behav, 51(4), 1995, pp. 693-698.

Barkai, E., and M. H. Hasselmo, "Acetylcholine and Associative Memory in the Piriform Cortex," Mol Neurobiol, 15(1), 1997, pp. 17-29.

Barker, W. W., D. Loewenstein, et al., "Effects of Physostigmine on Cerebral Glucose Metabolism (CMRglc) Measured by 18FDG/PET Studies in Normals," Soc Neurosci Abstr, 13, 1987, p. 1716.

Barlocco, D., G. Cignarella, et al., "Mono- and Disubstituted-3,8-Diazabicyclo[3.2.1]Octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling," J Med Chem, 41(5), 1998, pp. 674-681.

Barnaby, F., "Iran-Iraq War: The Use of Chemical Weapons Against the Kurds," Ambio, 17(6), 1985, pp. 407-408.

Barnes, J., and F. Denz, "The Reaction of Rats to Diets Containing Octamethyl Pyrophosphoramide (Schradan) and O,O Diethyl-S-Ethyl-Mercaptoethanol Thiophosphate (Systox)," Brit J Ind Med, 11, 1954, pp. 11-19.

Baron, J. A., "Beneficial Effects of Nicotine and Cigarette Smoking: The Real, the Possible and the Spurious," Br Med Bull, 52(1), 1996, pp. 58-73.

Baron, R., "Delayed Neurotoxicity and Other Consequences of Organophosphate Esters," Ann Rev Entomol, 26, 1981, pp. 29-48.

Barrett, D., and F. Oehme, "A Review of Organophosphorus-Induced Delayed Neurotoxicity," Vet Hum Toxicol, 27, 1985, pp. 22-37.

Bartels, C. F., F. S. Jensen, et al., "DNA Mutation Associated with the Human Butyrylcholinesterase K-Variant and Its Linkage to the Atypical Variant Mutation and Other Polymorphic Sites," Am J Hum Genet, 50, 1992, pp. 1086-1103.

Bascom, R., "Multiple Chemical Sensitivity: A Respiratory Disorder?" Toxicol Ind Health, 8, 1992, pp. 221-228.

Bassant, M. H., F. Jazat, and Y. Lamour, "Tetrahydroaminoacridine and Physostigmine Increase Cerebral Glucose Utilization in Specific Cortical and Subcortical Regions in the Rat," J Cereb Blood Flow and Metab, 13(5), 1995, pp. 855-864.

Battin, D., and T. Varkey, "Neuropsychiatric Manifestations of Bromide Ingestion," Postgraduate Medical Journal, 58, 1982, pp. 523-524.

Baumsweiger, W., personal communication, 1998.

Baynes, R. E., K. B. Halling, et al., "The Influence of Diethyl-m-Toluamide (DEET) on the Percutaneous Absorption of Permethrin and Carbaryl," Toxicol Appl Pharmacol, 144(2), 1997, pp. 332-339.

Beach, J., A. Spurgeon, et al., "Abnormalities on Neurological Examination Among Sheep Farmers Exposed to Organophosphorous Pesticides," Occup Environ Med, 53, 1996, pp. 520-525.

Beale, P., "Gulf Illness," BMJ, 308(6943), 1994, p. 1594.

Beatty, W., N. Butters, et al., "Patterns of Memory Failure After Scopolamine Treatment: Implications for Cholinergic Hypotheses of Dementia," Behav Neural Biol, 45, 1986, pp. 196-211.

Beekman, R., J. B. Kuks, et al., "Myasthenia Gravis: Diagnosis and Follow-Up of 100 Consecutive Patients," J Neurol, 244(2), 1997, pp. 112-118.

Beeri, R., A. Gnatt, et al., "Testicular Amplification and Impaired Transmission of Human Butyrylcholinesterase cDNA in Transgenic Mice," Human Reproduction, 9(2), 1994, pp. 284-292.

Beeri, R., et al., "Transgenic Expression of Human Acetylcholinesterase Induces Progressive Cognitive Deterioration in Mice," Curr Biol, 5(2), 1995, pp. 1063-1071.

Bell, I., C. Miller, et al., "An Olfactory-Limbic Model of Multiple Chemical Sensitivity Syndrome: Possible Relationships to Kindling and Affective Spectrum Disorders," Biol Psychiatry, 32, 1992, pp. 218-242.

Bell, I., G. Schwartz, et al., "Self-Reported Illness from Chemical Odors in Young Adults Without Clinical Syndromes or Occupational Exposures," Archives of Environmental Health, 48(1), 1993a, pp. 6-13.

Bell, I., G. Schwartz, et al., "Symptom and Personality Profiles of Young Adults from a College Student Population with Self-Reported Illness from Foods and Chemicals," J Am Coll Nutrition, 12(6), 1993b, pp. 693-702.

Bell, I., G. Schwartz, et al., "Sensitization to Early Life Stress and Response to Chemical Odors in Older Adults," Biol Psychiatry, 35, 1994, pp. 857-863.

Belova, I., and G. Jonsson, "Blood-Brain Barrier Permeability and Immobilization Stress," Acta Physiol Scand, 116, 1982, pp. 21-29.

Ben-Nathan, D., S. Lustig, et al., "Stress-Induced Neuroinvasiveness of a Neurovirulent Noninvasive Sindbis Virus in Cold or Isolation Subjected Mice," Life Sci, 48, 1991, pp. 1493-1500.

Bennett, R., "Fibromyalgia: The Commonest Cause of Widespread Pain," Comprehensive Therapy, 21(6), 1995, pp. 269-275.

Benowitz, N. L., "Pharmacology of Nicotine: Addiction and Therapeutics," Ann Rev Pharmacol Toxicol, 36, 1996, pp. 597-613.

Benwell, M., D. Balfour, et al., "Evidence That Tobacco Smoking Increases the Density of (-)-[3H]nicotine Binding Sites in Human Brain," J Neurochemistry, 50, 1988, pp. 1243-1247.

Berenbaum, M., "The Expected Effect of a Combination of Agents: The General Solution," J Theoretical Biology, 114, 1985, pp. 413-431.

Berezuk, G., and G. McCarty, "Investigational Drugs and Vaccines Fielded in Support of Operation Desert Storm," Milit Med, 157, 1992, pp. 404-406.

Berglund, M., S. Nielsen, et al., "Regional Cerebral Blood Flow in a Case of Bromide Psychosis," Arch Psychiat Nervenkr, 223, 1977, pp. 197-201.

Berkowitz, A., L. Sutton, et al., "Pilocarpine, an Orally Active Muscarinic Cholinergic Agonist, Induces REM Sleep and Reduces Delta Sleep in Normal Volunteers," Psychiatry Res, 33, 1990, pp. 113-119.

Berman, P., and J. Patrick, "Experimental Myasthenia Gravis," J Exp Med, 151, 1980, pp. 204-223.

Berry, W., and D. Davies, "The Use of Carbamates and Atropine in the Protection of Animals Against Poisoning by 1.2.1-Trimethylpropylmethyl Phosphonofluoridate," Biochem Pharmacol, 19(1), 1970, pp. 927-934.

Birchall, J., and J. Chappell, "Aluminium, Chemical Physiology, and Alzheimer's Disease," Lancet, 2, 1988, pp. 1008-1010.

Birtley, R., J. Toberts, et al., "Excretion and Metabolism of (14C)-Pyridostigmine in the Rat," Br J Pharmacol, 26, 1966, pp. 393-402.

Birtwistle, J., "Quitting Smoking Could Increase Your Risk of Surgery for Ulcerative Colitis," Br J Theatre Nurs, 5(6), 1995, pp. 27-28.

Birtwistle, J., "The Role of Cigarettes and Nicotine in the Onset and Treatment of Ulcerative Colitis," Postgrad Med J, 72(854), 1996, pp. 714-718.

Bishop, C., Neural Networks for Pattern Recognition, Oxford, England: Oxford University Press, 1995.

Blackhall, M., G. Buckley, et al., "Drug-Induced Neonatal Myasthenia," J Obstet Gynaec Brit Cwlth, 76, 1969, pp. 157-162.

Blake, P., R. Gleadle, et al., "Evaluation of Pyridostigmine Bromide as a Pretreatment for Nerve Agent Poisoning (External Studies)," Porton Down, U.K.: Chemical Defence Establishment, 1985.

Blick, D., S. Kerenyi, et al., "Behavioral Toxicity of Anticholinesterases in Primates: Chronic Pyridostigmine and Soman Interactions," Pharmacol Biochem Behav, 38, 1991, pp. 527-532.

Blick, D. W., M. R. Murphy, et al., "Acute Behavioral Toxicity of Pyridostigmine or Soman in Primates," Toxicol and Appl Pharmacol, 126, 1994, pp. 311-318.

Blick, D., M. Murphy, et al., "Effects of Carbamate Pretreatment and Oxime Therapy on Soman-Induced Performance Decrements and Blood Cholinesterase Activity in Primates," Soc Neurosci Abstr, 13, 1987, p. 1716.

Blick, D. W., F. Weathersby, et al., "Behavioral Toxicity of Anticholinesterases in Primates: Effects of Daily Repeated Soman Exposure," Pharmacology Biochemistry and Behavior, 48(3), 1994, pp. 643-649.

Blin, J., P. Mazetti, et al., "Does the Enhancement of Cholinergic Neurotransmission Influence Brain Glucose Kinetics and Clinical Symptomatology in Progressive Supranuclear Palsy?" Brain, 118(Pt 6), 1995, pp. 1485-1495.

Blomquist, L., and W. Thorsell, "Distribution and Fate of the Insect Repellent 14C-N,N-Diethyl-m-Toluamide in the Animal Body. II. Distribution and Excretion After Cutaneous Application," Acta Pharmacol Toxicol, 41, 1977, pp. 235-243.

Blumberg, A., and W. Nelp, "Total Body Bromide Excretion in a Case of Prolonged Bromide Intoxication," Helvetica Medica Acta, 1966, pp. 330-333.

Bokina, A., N. Eksler, et al., "Investigation of the Mechanism of Action of Atmospheric Pollutants on the Central Nervous System and Comparative Evaluation of Methods of Study," Environ Health Prospect, 13, 1976, pp. 37-42.

Bombinski, T., and K. DuBois, "Toxicity and Mechanism of Action of Disyston," AMA Arch Ind Health, 17, 1958, pp. 192-199.

Bonapace, C. R., and D. A. Mays, "The Effect of Mesalamine and Nicotine in the Treatment of Inflammatory Bowel Disease," Ann Pharmacother, 31(7-8), 1997, pp. 907-913.

Borges, M., R. Castro, et al., "Different Effects of Pyridostigmine on Growth Hormone (GH) Response to GH-Releasing Hormone in Endogenous and Exogenous Hypercortisolemic Patients," Brazilian J Med Biol Res, 26, 1993, pp. 1191-1200.

Borland, R., D. Brennan, et al., "Studies on the Possible Central and Peripheral Effects in Man of a Cholinesterase Inhibitor (Pyridostigmine)," Hum Toxicol, 4, 1985, pp. 293-300.

Bowers, M., E. Goodman, et al., "Some Behavioral Changes in Man Following Anticholinesterase Administration," J Nerv Ment Dis, 138, 1964, p. 383.

Bowman, P., S. Schuschereba, et al., "Myopathic Changes in Diaphragm of Rats Fed Pyridostigmine Bromide Subchronically," Fundam Appl Toxicol, 13, 1989, pp. 110-117.

Bradbury, M., J. Burden, "Stimulation Electrically and by Acetylcholine of the Rat Hypothalamus in Vitro," J Physiol (Lond), 239, 1974, p. 269.

Braga, M., E. Rowan, et al., "Prejunctional Action of Neostigmine on Mouse Neuromuscular Preparations," Brit J Anesthesia, 70, 1993, pp. 405-410.

Braham, J., "Drop Attacks in the Elderly: Effect of Pyridostigmine," Postgraduate Medical Journal, 70(829), 1994, p. 848.

Brake, B., response to inquiry, 1997.

Breyer-Pfaf, U., U. Maier, et al., "Pyridostigmine Kinetics in Healthy Subjects and Patients with Myasthenia Gravis," Clin Pharmacol Ther, 37, 1985, pp. 495-501.

Briggs, G., R. Freeman, et al., eds., Drugs in Pregnancy and Lactation, Baltimore: Williams and Wilkins, 1990.

Brodeur, J., and K. DuBois, "Studies of the Mechanism of Acquired Tolerance by Rats to O,O Diethyl S-2-(ethylthio)ethyl Phosphorodithioate (Di-Syston)," Arch Int Pharmacodyn, 149, 1964, pp. 560-570.

Brooks, R., D. Hubbard, et al., "Effects of Pyridostigmine Bromide on A-10 Pilots During Execution of a Simulated Mission: Performance," Fort Detrick, Md.: U.S. Army Medical R&D Command, 1992.

Brown, D., "Slow Cholinergic Excitation--A Mechanism for Increasing Neuronal Excitability," Trends Neurosci, 6, 1983, pp. 302-306.

Brown, G., and F. Goodwin, "Cerebrospinal Fluid Correlates of Suicide Attempts and Aggression," Psychobiology of Suicide, 487, 1986a, pp. 175-188.

Brown, G., and F. Goodwin, "Human Aggression and Suicide," Suicide and Life-Threatening Behavior, 16, 1986b, pp. 141-161.

Brown, G., F. Goodwin, et al., "Aggression in Humans Correlates with Cerebrospinal Fluid Amine Metabolites," Psychiatry Research, 1, 1979, pp. 131-139.

Brown, G., F. Goodwin, et al., "Human Aggression and Suicide: Their Relationship to Neuropsychiatric Diagnoses and Serotonin Metabolism," in B. Ho, J. Schoolar, and E. Usdin, eds., Serotonin in Biological Psychiatry: Advances in Biochemical Psychopharmacology, New York: Raven Press, 1982.

Brown, G., M. Ebert, et al., "Aggression, Suicide and Serotonin: Relationships to CSF Amine Metabolites," Am J Psychiat, 139, 1982, pp. 741-716.

Brown, H., "Electroencephalographic Changes and Disturbance of Brain Function Following Human Organophosphate Exposure," Northwest Med, 70, 1971, pp. 845-846.

Brugada, R., N. Wenger, et al., "Changes in Plasma Cholesterol Levels After Hospitalization for Acute Coronary Events," Cardiology, 87(3), 1986, pp. 194-199.

Brust, P., "Blood-Brain-Barrier Transport Under Different Physiological and Pathophysiological Circumstances Including Ischemia," Exp Pathol, 42, 1991, pp. 213-219.

Buccafusco, J., M. Prendergast, et al., "A Rate Model for Gulf War Illness-Related Selective Memory Impairment and the Loss of Hippocampal Nicotinic Receptors," Society for Neuroscience Abstracts, 23, 1997, part 1, p. 90.19.

Burchfiel, J. L., and F. H. Duffy, "Organophosphate Neurotoxicity: Chronic Effects of Sarin on the Electroencephalogram of Monkey and Man," Neurobehavioral Toxicology and Teratology, 4, 1982, pp. 767-778.

Butterfield, P. G., B. G. Valanis, et al., "Environmental Antecedents of Young-Onset Parkinson's Disease," Neurology, 43(6), 1993, pp. 1150-1158.

Cain, D., and M. Corcoran, "Epileptiform Effects of Met-enkephalin, §-Endorphin, and Morphine: Kindling of Generalized Seizures and Potentiation of Epileptiform Effects by Handling," Brain Res 338, 1985, pp. 327-336.

Callender, T. J., L. Morrow, and K. Subramanian, "Evaluation of Chronic Neurological Sequelae After Acute Pesticide Exposure Using SPECT Brain Scans," (published erratum appears in J Toxicol Environ Health, 44(2), 1995, pp. vii-viii), J Toxicol Environ Health, 41(3), 1994, pp. 275-284.

Campbell, S., J. Gillin, et al., "Lithium Delays Circadian Phase of Temperature and REM Sleep in a Bipolar Depressive: A Case Report," Psychiatry Res, 27, 1989, pp. 23-29.

Canadian Department of National Defence, "Health Study of Canadian Forces Personnel Involved in the 1991 Conflict in the Persian Gulf, Volumes I and II, prepared for the Gulf War Illness Advisory Committee, Department of National Defence, by Goss Gilroy, Inc., Management Consultants, Ottawa, April 20, 1998,

Capacio, B., C. Byers, et al., "Drug Interaction Studies of Pyridostigmine with the 5HT3 Receptor Antagonist Ondansetron and Granisetron in Guinea Pigs," Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, 1993.

Capacio, B., I. Koplovitz, et al., "Drug Interaction Studies of Pyridostigmine with the 5HT3 Receptor Antagonist Ondansetron and Granisetron in Guinea Pigs," Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, 1995.

Cappa, M., A. Grossi, et al., "Effect of the Enhancement of the Cholinergic Tone by Pyridostigmine on the Exercise-Induced Growth Hormone Release in Man," J Endocrinol Invest, 16, 1993, pp. 421-424.

Carney, M., "Bromism--A Clinical Chameleon," Nursing Times, July 5, 1973, pp. 859-861.

Carney, M., "Five Cases of Bromism," Lancet, II, 1971, pp. 523-524.

Casida, J., D. Gamman, et al., "Mechanisms of Selective Actions of Pyrethroid Insecticides," Ann Rev Pharmacol Toxicol, 23, 1983, pp. 413-438.

Cassel, W., T. Ploch, et al., "Risk of Traffic Accidents in Patients with Sleep-Disordered Breathing: Reduction with Nasal CPAP," European Respiratory Journal, 9(12), 1986, pp. 2606-2611.

Centers for Disease Control and Prevention (CDC), "Unexplained Illness Among Persian Gulf War Veterans in an Air National Guard Unit: Preliminary Report--August 1990-March 1995," MMWR, 44, 1995, pp. 443-447.

Chaney, L., J. Moss, et al., "Toxic Interactions Between Pyridostigmine (PB), N,N-Diethyl-m-Toluamide (DEET), Adrenergic Agents and Caffeine (Abstract)," SOT 1997 Annual Meeting, 1997.

Chang, H., and E. Neumann, "Dynamic Properties of Isolated Acetylcholine Receptor Proteins: Release of Calcium Ion Caused by Acetylcholine Binding," Proc Natl Acad Sci USA, 73(10), 1976, pp. 3364-3368.

Changeux, J.-P., A. Bessis, et al., "Nicotinic Receptors and Brain Plasticity," Cold Spring Harbor Symposia on Quantitative Biology, 66, 1996, pp. 343-362.

Chiappa, S., S. Padilla, et al., "Slow Accumulation of Acetylcholinesterase in Rat Brain During Enzyme Inhibition by Repeated Dosing with Chlorpyrifos," Biochemical Pharmacology, 49(7), 1995, pp. 955-963.

Christie, J. E., A. Shering, et al., "Physostigmine and Arecoline: Effects of Intravenous Infusions in Alzheimer Presenile Dementia," Br J Psychiatry, 138, 1981, pp. 46-50.

Chubb, I. W., A. J. Hodgson, and G. H. White, "Acetylcholine Hydrolyzes Substance P," Neuroscience, 5, 1980, pp. 2065-2072.

Clawson, R., personal communication, 1997, 1998, and 1999.

Clark, G., "Organophosphate Insecticides and Behavior: A Review," Aerosp Med, 4, 1971, pp. 735-740.

Clement, J. G., D. G. Bailey, et al., "The Acetylcholinesterase Oxime Reactivator HI-6 in Man: Pharmacokinetics and Tolerability in Combination with Atropine," Biopharm Drug Dispos, 16(5), 1995, pp. 415-425.

Clement, J., "Hormonal Consequences of Organophosphate Poisoning," Fund Appl Toxicol, 5, 1985, pp. S61-S77.

Clement, J., "Distribution of Pyridostigmine in Rats and Guinea Pigs," Suffield Technical Paper 464, 1977.

Coccaro, E. F., "Central Serotonin and Impulsive Aggression," BJP, December (8), 1989, Supplement, pp. 52-62.

Coccaro, E. F., L. J. Siever, et al., "Serotonergic Studies in Patients with Affective and Personality Disorders. Correlates with Suicidal and Impulsive Aggressive Behavior" (published erratum appears in Arch Gen Psychiatry, 47(2), 1990, p. 124), Arch Gen Psychiatry, 46(7), 1989, pp. 587-599.

Cohan, S., K. Drettchen, et al., "Malabsorption of Pyridostigmine in Patients with Myasthenia Gravis," Neurology, 27, 1977, pp. 299-301.

Cohan, S. L., J. L. Pohlmann, et al., "The Pharmacokinetics of Pyridostigmine," Neurology, 26, 1976, pp. 536-539.

Coiro, V., R. Volpi, et al., "Different Effects of Pyridostigmine on the Thyrotropin Response to Thyrotropin-Releasing Hormone in Endogenous Depression and Subclinical Thyrotoxicosis," Metabolism, 47(1), 1998, pp. 50-53.

Collins, A., and M. Marks, "Regulation of Behavioral and Physiological Sensitivity to Nicotine by Brain Nicotinic Receptors," in F. Clement, ed., Nicotinic Acetylcholine Receptors in the Nervous System, New York: Springer-Verlag, 1988.

Committee on Veterans Affairs, "Is Military Research Hazardous to Veterans' Health? Lessons from World War II, The Persian Gulf, and Today," hearing U.S. Senate, Washington, D.C., 1994.

Committee to Review the Health Consequences of Service During the Persian Gulf War (IOM), Health Consequences of Service During the Persian Gulf War: Recommendations for Research and Information Systems, Washington, D.C.: National Academy Press, 1996.

Committee to Study the Interactions of Drugs, Biologics, and Chemicals in US Military Forces, Interactions of Drugs, Biologics, and Chemicals in US Military Forces, Washington, D.C.: National Academy Press, 1996.

Conti-Fine, B., and R. Horton, "A `Neuronal' Nicotinic Acetylcholine Receptor Regulating Cell Adhesion Is Expressed in Human Epidermal Keratinocytes," International Symposium on the Cholinergic Synapse: Structure, Function, and Regulation (3rd), Baltimore: University of Maryland, 1994.

Cook, J., M. Kolka, et al., "Chronic Pyridostigmine Bromide Administration: Side Effects Among Soldiers Working in a Desert Environment," Military Medicine, 157, 1992, pp. 250-254.

Coppen, A., C. Swade, and K. Wood, "Platelet 5-Hydroxytryptamine Accumulation in Depressive Illness," Clinica Chimica Acta, 87(1), 1978, pp. 165-168.

Corringer, P.-H., S. Bertrand, et al., "Critical Elements Determining Diversity in Agonist Binding and Desensitization of Neuronal Nicotinic Acetylcholine Receptors," J of Neuroscience, 18(2), 1998, pp. 648-657.

Corsello, S., A. Tofani, et al., "Effects of Sex and Age on Pyridostigmine Potentiation of Growth Hormone-Releasing Hormone-Induced Growth Hormone Release," Neuroendocrinology, 56, 1991, pp. 208-213.

Costa, L., et al., "Species Differences in Serum Paraoxonase Activity Correlate with Sensitivity to Paraoxon Toxicity, in L. Costa et al., eds., Toxicology of Pesticides: Experimental, Clinical, and Regulatory Aspects, NATO ASI series, Berlin: Springer-Verlag, 1987, H13, pp. 263-266.

Costa, L., et al., "Serum Paraoxonase and Its Influence on Paraoxon and Chlorpyrifos-Oxon toxicity in Rats," Toxicol Appl Pharmacol, 103, 1990, pp. 66-76.

Costa, L., B. Schwab, et al., "Reduced [3Hquinuclidinyl Benzilate Binding to Muscarinic Receptors in Disulfoton-Tolerant Mice," Toxicol Appl Pharmacol, 60, 1981, pp. 441-450.

Costa, L., B. Schwab, et al., "Differential Alterations of Cholinergic Muscarinic Receptors in Chronic and Acute Tolerance to Organophosphorus Insecticides," Biochem Pharmacol, 31, 1982a, pp. 3407-3413.

Costa, L., B. Schwab, et al., "Tolerance to Anticholinesterase Compounds in Mammals," Toxicology, 25, 1982b, pp. 79-97.

Cowan, D. N., R. F. De Fraites, et al., "The Risk of Birth Defects Among Children of Persian Gulf War Veterans," New Engl J Med, 336, 1997, pp. 1650-1656.

Cronnelly, R., D. Stanski, et al., "Pyridostigmine Kinetics with and Without Renal Function," Clin Pharmacol Ther, 28, 1980, pp. 78-81.

Cullen, M., "The Worker with Multiple Chemical Sensitivities: An Overview," Occupational Medicine, 2(4), 1987, pp. 655-661.

Cupler, F. J., C. Otero, et al., "Acetylcholine Receptor Antibodies as Markers of Treatable Fatigue in HIV-1 Infected Individuals," Muscle and Nerve, 19, 1996, pp. 1186-1188.

Currie, E., "The Gulf War Syndrome (letter)," BMJ, 310(6990), 1995, pp. 1334-1335.

Dagan, Y., P. Lavie, et al., "Elevated Awakening Thresholds in Sleep Stage 3-4 in War-Related Post-Traumatic Stress Disorder," Biol Psychiatry, 30, 1991, pp. 618-622.

Damaj, M. I., K. R. Creasy, et al., "Pharmacological Effects of Epibatidine Optical Enantiomers," Brain Res, 664(1-2), 1994, pp. 34-40.

Damaj, M. I., and B. R. Martin, "Tolerance to the Antinociceptive Effect of Epibatidine After Acute and Chronic Administration in Mice," Eur J Pharmacol, 300(1-2), 1996, pp. 51-57.

Daniell, W., S. Barnhart, et al., "Neuropsychological Performance Among Agricultural Pesticide Applicators," Environ Res, 59(1), 1992, pp. 217-228.

Davidoff, A., and P. Keyl, "Symptoms and Health Status in Individuals with Multiple Chemical Sensitivities Syndrome from Four Reported Sensitizing Exposures and a General Population Comparison Group," Archives of Environmental Health, 51(3), 1996, pp. 201-213.

Davies, D., P. Holland, et al., "The Relationship Between the Chemical Structure and Neurotoxicity of Alkyl Organophosphorus Compounds," Br J Pharmacol, 23, 1960, pp. 295-304.

Davies, H., R. Richter, et al., "The Effect of the Human Serum Paraoxonase Polymorphism Is Reversed with Diazonon, Soman, and Sarin," Nature Genetics, 14, 1996, pp. 334-336.

Davies, J., "Neurotoxic Concern of Human Pesticide Exposures," Am J Ind Med, 18, 1990, pp. 327-331.

Davila, D. G., R. D. Hurt, et al., "Acute Effects of Transdermal Nicotine on Sleep Architecture, Snoring, and Sleep-Disordered Breathing in Nonsmokers," Am J Respir Crit Care Med, 150(2), 1994, pp. 469-474.

Davis, B., and K. Davis, "Acetylcholine and Anterior Pituitary Hormone Secretion," in K. Davis and P. Berger, eds., Brain Acetylcholine and Neuropsychiatric Disease, New York: Plenum Press, 1979, pp. 445-458.

Davis, D., "Reduced Ratio of Male to Female Births in Several Industrial Countries: A Sentinel Health Indicator?" JAMA, 279, 1998, pp. 1018-1023,

Davis, K., K. Faull, et al., "Physostigmine Related Changes in Cerebrospinal Fluid Neurotransmitter Metabolites in Man," in K. Davis and P. Berger, eds., Brain Acetylcholine and Neuropsychiatric Disease, New York: Plenum Press, 1979, pp. 435-443.

Davis, K. L., R. C. Mohs, et al., "Physostigmine: Improvement of Long-Term Memory Processes in Normal Humans," Science, 201(4352), 1978, pp. 272-274.

Davis, K. L., and H. I. Yamamura, "Cholinergic Underactivity in Human Memory Disorders," Life Sci, 23(17-18), 1978, pp. 1729-1733.

Davis, K. L., J. A. Yesavage, et al., "Single Case Study. Possible Organophosphate-Induced Parkinsonism," J Nerv Ment Dis, 166(3), 1978, pp. 222-225.

De Bleecker, J. L., "Intermediate Syndrome: Prolonged Cholinesterase Inhibition" (letter), J Toxicol Clin Toxicol, 31(1), 1993, pp. 197-199.

De Bleecker, J., K. Van Den Neucker, et al., "The Intermediate Syndrome in Organophosphate Poisoning: Presentation of a Case and Review of the Literature" (published erratum appears in J Toxicol Clin Toxical, 30(4), 1992, p. 697), J Toxicol Clin Toxicol, 30(3), 1992, pp. 321-329, pp. 331-332 (discussion).

Defense Science Board Task Force on Persian Gulf War Health Effects, "Report of the Defense Science Board Task Force on Persian Gulf War Health Effects," Washington, D.C., Office of the Under Secretary of Defense for Acquisition and Technology, 1994.

De Fraites, R., "Pyridostigmine Bromide (PB) Use in Operations Desert Shield and Desert Storm (ODS)," information paper, DASG-HS-PM, 1996.

De Fraites, R., E. I. Wanat, et al., "Investigation of a Suspected Outbreak of an Unknown Disease Among Veterans of Operation Desert Shield/Storm 123rd Army Reserve Command, Fort Benjamin Harrison, Indiana, April 1992," Washington, D.C.: Walter Reed Army Institute of Research, 1992.

De Garbino, J. P., and A. Laborde, "Toxicity of an Insect Repellent: N-N-Diethyltoluamide," Veterinary and Human Toxicology, 25(6), 1983, pp. 422-423.

Department of Defense. comments on Public Citizen Litigation Group's Petition to Repeal Interim Rule on the Treatment Use Without Informed Consent of Investigational New Drugs in Military Combat Exigency, 1996.

Department of Defense, "Comprehensive Clinical Evaluation Program for Persian Gulf War Veterans: CCEP Report on 18,598 Participants," 1996.

Dettbarn, W.-D., "Pesticide Induced Muscle Necrosis: Mechanisms and Prevention," Fundam Appl Toxicol, 4, 1984, pp. S18-S26.

Deutsch, J., and J. Roger, "Cholinergic Excitability and Memory: Animal Studies and Their Clinical Implications," in K. Davis and P. Berger, eds., Brain Acetylcholine and Neuropsychiatric Disease, New York: Plenum Press, 1979, pp. 175-204.

Devinsky, O., J. Kernan, et al., "Aggressive Behavior Following Exposure to Cholinesterase Inhibitors," J Neuropsychiatry and Clin Neurosciences, 4, 1992, pp. 189-194.

Deyi, X., W. Limxiu, et al., "The Inhibition and Protection of Cholinesterase by Physostigmine and Pyridostigmine Against Soman Poisoning in Vivo," Fundam Appl Toxicol, 1, 1981, pp. 217-221.

Didier, M., S. Bursztajn, et al., "DNA Strand Breaks Induced by Sustained Glutamate Excitotoxicity in Primary Neuronal Cultures," J of Neurosci, 16(7), 1996, pp. 2238-2250.

Dietrich, W. D., M. D. Ginsburg, et al., "Effects of Physostigmine on Local Glucose Utilization in the Rat," Ann Neurol, 16(1), 1984, pp. 117-118 (abstract).

Dille, J., and P. Smith, "Central Nervous System Effects of Chronic Exposure to Organophosphate Insecticides," Aerosp Med, 35, 1964, p. 475.

Dimsdale, J., and J. Herd, "Variability of Plasma Lipids in Response to Emotional Arousal," Psychosom Med, 44, 1982, pp. 413-430.

Dinan, T., V. O'Keane, et al., "Pyridostigmine Induced Growth Hormone Release in Mania: Focus on the Cholinergic/Somatostatin System," Clinical Endocrinology, 40, 1994, pp. 93-96.

Dirnhuber, P. and M. C. French, "Effectiveness of Pyridostigmine in Reversing the Neuromuscular Blockade Produced by Soman," J Pharm Pharmacol, 30, 1978, pp. 419-425.

Dirnhuber, P., M. C. French, et al., "The Effect of Chronic Administration of Pyridostigmine in the Rat, Guinea Pig, and Rhesus Monkey," Chemical Defence Establishment Technical Paper 218, Porton Down, U.K., 1977.

Dirnhuber, P., M. French, et al., "The Protection of Primates Against Soman Poisoning by Pretreatment with Pyridostigmine," J Pharm Pharmacol, 31, 1979, pp. 295-299.

Dirnhuber, P. and D. M. Green, "Effectiveness of Pyridostigmine in Reversing the Neuromuscular Blockade Produced by GD," Chemical Defence Establishment Technical Paper 231, Porton Down, U.K., 1977.

Dirnhuber, P., D. M. Green, et al., "Comparison Between the Bromide and Methane Sulphonate Salts of Pyridostigmine as Pretreatmetn against Nerve Agent Poisoning," Chemical Defense Establishment, Porton Down, U. K., 1978.

D'Mello, G., "Behavioral Toxicity of Anticholinesterases in Humans and Animals--A Review," Hum Exp Toxicol, 12, 1993, pp. 3-7.

D'Mello, G., N. Cross, et al., "A Novel Method to Enable Evaluation of Relative Effect--Application to the Comparison of Different Medical Countermeasures for Nerve Agent Poisoning (U)," Chemical and Biological Defence Establishment. Porton Down, U.K., 1994.

D'Mello, G., S. Miles, et al., "Protection Against Nerve Agent Poisoning: An Overview of Animal Behavioural Toxicological Studies and Their Implications for Man," Chemical and Biological Defence Establishment, Porton Down, U.K., 1988.

D'Mello, G., and E. Scott, "Relative Efficacy of Pretreatment with Physostigmine and Hyoscine Against GB and GD in Marmosets: Evaluation Using Clinical Signs and Eye-Hand Co-ordination Performance as Indices of Residual Toxicity," Chemical and Biological Defence Establishment, Porton Down, U.K., 1990.

Doctor, B., D. Blick, et al., "Cholinesterases as Scavengers for Organophosphorus Compounds: Protection of Primate Performance Against Soman Toxicity," Chem Biol Interact, 87, 1993, pp. 285-293.

Dominguez, R. A., and P. J. Goodnick, "Adverse Events After the Abrupt Discontinuation of Paroxetine," Pharmacotherapy, 15(6), 1995, pp. 778-780.

Donnay, A., personal communication, 1999.

Donnelly-Roberts, D. L., P. S. Puttfarcken, et al., "ABT-594 [(R)-5-(2-Azetidinylmethoxy)-2-Chloropyridine]: A Novel, Orally Effective Analgesic Acting via Neuronal Nicotinic Acetylcholine Receptors: I. In Vitro Characterization," J Pharmacol Exp Ther, 285(2), 1998, pp. 777-786.

Dorner, G., K. Hecht, et al., "Teratopsychogenetic Effects Apparently Produced by Nonphysiological Neurotransmitter Concentrations During Brain Differentiation," Endokrinologie, 68(1), 1976, pp. 1-5.

Dorner, G., and G. Hinz, "Apparent Effects of Neurotransmitters on Sexual Differentiation of the Brain Without Mediation of Sex Hormones," Endokrinologie, 71(1), 1978, pp. S104-S108.

Dorner, G., J. Staudt, et al., "Further Evidence of Teratogenic Effects Apparently Produced by Neurotransmitters During Brain Differentiation," Endokrinologie, 70(3), 1977, pp. S326-S330.

Doty, R., et al., "Olfactory Sensitivity, Nasal Resistance, and Autonomic Function in Patients with Multiple Chemical Sensitivities," Arch Otolaryngol-Head and Neck Surg, 144, 1988, pp. 1422-1427.

Doyle, P., E. Roman, et al., "Birth Defects Among Children of Persian Gulf War Veterans (letter)," New Engl J Med, 337, 1997, p. 1175.

Drachman, D., "Memory and Cognitive Function in Man: Does the Cholinergic System Have a Specific Role?" Neurology, 27, 1977, p. 783.

Drachman, D., "Myasthenia Gravis," New Engl J Med, 330(25), 1994, pp. 1797-1810.

Drachman, D., and J. Leavitt, "Human Memory and the Cholinergic System," Arch Neurol, 30, 1974, p. 113.

Drenth, J., I. Ensberg, et al., "Neuromuscular Function in Agricultural Workers Using Pesticides," Arch Envir Health, 25, 1972, pp. 395-398.

Dringenberg, H. C., M. A. De Souza-Silva, et al., "Histamine H1 Receptor Antagonists Produce Increases in Extracellular Acetylcholine in Rat Frontal Cortex and Hippocampus," J Neurochem, 70(4), 1998, pp. 1750-1758.

Duffy, F., and J. Burchfiel, "Long Term Effects of the Organophosphate Sarin on EEGs in Monkeys and Humans," Neurotoxicology, 1, 1980, pp. 667-689.

Duffy, F., J. Burchfiel, et al., "Long Term Effects of an Organophosphate upon the Human Electroencephalogram," Toxicol Appl Pharmacol, 46, 1979, pp. 161-176.

Duggan, A., and D. Smith, "Physiological Aspects of an Investigation into the Effects of Pyridostigmine Bromide Pretreatment on Work Capacity in the Heat," Institute of Naval Medicine (U.K.), 1982.

Dummer, S., A. Lee, et al., "Investigation of Cytomegalovirus Infection as a Risk Factor for Coronary Atherosclerosis in the Explanted Hearts of Patients Undergoing Heart Transplantation," J Med Virol, 44(3), 1994, pp. 305-309.

Duna, G., and W. Wilke, "Diagnosis, Etiology and Therapy of Fibromyalgia," Comprehensive Therapy, 19(2), 1993, pp. 60-63.

Dunn, M., B. Hackley, et al., "Chapter 6: Pretreatment for Nerve Agent Exposure," in R. Bellamy, F. Sidell, E. Takafuji, and D. Franz, eds., Textbook of Military Medicine. Part I. Medical Aspects of Chemical and Biological Warfare, Office of the Surgeon General, Department of the Army, 262, 1997, pp. 649-652.

Dunn, M., and F. Sidell, "Progress in Medical Defense Against Nerve Agents," JAMA, 262(5), pp. 649-652.

Durham, W., H. Wolfe, et al., "Organophosphorous Insecticides and Mental Alertness," Arch Environ Health, 10, 1965, pp. 55-66.

Duvoisin, R., E. Deneris, et al., "The Functional Diversity of the Neuronal Nicotinic Acetylcholine Receptors Is Increased by a Novel Subunit: §4," Neuron, 3, 1989, pp. 487-496.

Dvorska, I., et al., "On the Blood-Brain Barrier to Peptides: Effects of Immobilization Stress on Regional Blood Supply and Accumulation of Labeled Peptides in the Rat Brain," Endocr Res, 26, 1992, pp. 77-82.

Dwyer, J., USC Department of Research, personal communication, 1998.

Eakman, G., J. Dallas, et al., "The Effects of Testosterone and Dihydrotestosterone on Hypothalamic Regulation of Growth Hormone Secretion," J Clin Endocrinol and Metabolism, 81(3), 1996, pp. 1217-1223.

Eastwood, J., G. Levine, et al., "Aluminium Deposition in Bone After Contamination of Drinking Water," Lancet, 2, 1990, pp. 462-464.

Eaton, L., and E. Lambert, "Electromyography and Electrical Stimulation of Nerve in Diseases of Motor Units," JAMA, 163, 1957, pp. 1117-1124.

Eberly, R., and B. Engdahl, "Prevalence of Somatic and Psychiatric Disorders Among Foreign Prisoners of War," Hospital and Community Psychiatry, 42(8), 1991, pp. 807-813.

Ecobichon, D., J. Davies, et al., "Neurotoxic Effects of Pesticides, in S. Baker and C. Wilkinson, eds., The Effect of Pesticides on Human Health, Princeton, N. J.: Princeton Scientific Publishers, 1990, pp. 131-199.

Edwards, D., and C. Johnson, "Insect-Repellent-Induced Toxic Encephalopathy in a Child," Clin Pharmacol, 6, 1987, pp. 496-498.

Ehlert, F., N. Kokka, et al., "Altered (3H)-Quinuclidinyl Benzilate Binding in the Striatum of Rats Following Chronic Cholinesterase Inhibition with Diisopropylfluorophosphate," Mol Pharmacol, 17, 1980, pp. 24-30.

Ehlert, F., N. Kokka, et al., "Muscarinic Subsensitivity in the Longitudinal Muscle of the Rat Ileum Following Anticholinesterase Treatment with Diisopropylfluorophosphate," Biochem Pharmacol, 29, 1980, pp. 1391-1397.

Ehrich, M., L. Shell, et al., "Short-Term Clinical and Neuropathologic Effects of Cholinesterase Inhibitors in Rats," J Am Coll Toxicol, 12, 1993, pp. 55-67.

Eichelman, B., "Role of Biogenic Amines in Aggressive Behavior," in M. Sandler, ed., Psychopharmacology of Aggression, New York: Raven Press, 1979, pp. 61-93.

Eiermann, B., N. Sommer, et al., "Renal Clearance of Pyridostigmine in Myasthenia Patients and Volunteers Under the Influence of Ranitidine and Pirenzepine," Xenobiotica, 23, 1993, pp. 1263-1175.

El-Fakahany, E., and E. Richelson, "Involvement of Calcium Channels in Short-Term Desensitization of Muscarinic Receptor-Mediated Cyclic G<P Formation in Mouse Neuroblastoma Cells," Proc Nat Acad Sci USA, 77, 1980, pp. 6897-6901.

El-Fakahany, E., and E. Richelson, "Phenoxybenzamine and Dibenamine Interactions with Calcium Channel Effectors of the Muscarinic Receptor," Mol Pharmacol, 20, 1981, pp. 519-525.

Elgoyen, A., D. Johnson, et al., Alpha 9: A New Acetylcholine Receptor with Novel Pharmacological Properties, International Symposium on the Cholinergic Synapse: Structure, Function and Regulation (3rd), Baltimore: University of Maryland, 1994.

Elin, R., E. Robertson, et al., "Bromide Interferes with Determination of Chloride by Each of Four Methods," Clin Chem, 27, 1981, pp. 778-779.

Ellenhorn, M., S. Schonwald, et al., Ellenhorn's Medical Toxicology, Baltimore: Williams and Wilkins, 1997.

Ellman, G., K. Coortney, et al., "A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity," Biochem Pharmacol, 7, 1961, pp. 88-95.

Ellman, P., D. King, et al., "Preictal Headache as a Potential Red Flag for Nonepileptic Seizures," American Epilepsy Society meeting, Boston, Mass., December 7-10, 1997, Epilepsia, 38, 1997, Supplement 8, p. 50.

Elsmore, T., "Circadian Susceptibility to Soman Poisoning," Fund Appl Toxicol, 1, 1981, pp. 238-241.

Elson, E., "Report on Possible Effects of Organophosphate `Low-Level' Nerve Agent Exposure," Health Affairs, 1996.

El-Yousef, M., D. Janowsky, et al., "Induction of Severe Depression by Physostigmine in Marihuana Intoxicated Individuals," Br J Addict Alcohol Other Drugs, 68(4), 1973, pp. 321-325.

Engel, A., E. Lambert, and T. Santa, "Study of Long-Term Anticholinesterase Therapy," Neurology, 23, 1973, p. 1273.

Engel, A., E. Lambert, et al., "A New Myasthenic Syndrome with End-Plate Acetylcholinesterase Deficiency, Small Nerve Terminals and Reduced Acetylcholine Release," Ann Neurol, 1, 1977, pp. 315-330.

Engel, A., E. Lambert, et al., "A Newly Recognized Congenital Myasthenic Syndrome Attributed to a Prolonged Open Time of the Acetylcholine-Induced Ion Channel," Ann Neurol, 11, 1981, pp. 553-569.

Epstein, Y., D. Seidman, et al., "Heat-Exercise Performance of Pyridostigmine-Treated Subjects Wearing Chemical Protective Clothing," Aviat Space Environ Med, 61, 1990, pp. 310-313.

Eriksson, P. U. Johansson, et al., "Neonatal Exposure to DDT Induces Increased Susceptibility to Pyrethroid (Bioallethrin) Exposure at Adult Age--Changes in Cholinergic Muscarinic Receptor and Behavioural Variables," Toxicol, 77(1-2), 1993, pp. 21-30.

Ernest, K., M. Thomas, et al., "Delayed Effects of Exposure to Organophosphorus Compounds," Indian J Med Res, 101, 1995, pp. 81-84.

Fagerstrom, K., O. Pomerleau, et al., "Nicotine May Relieve Symptoms of Parkinson's Disease," Psychopharmacology, 116, 1994, pp. 117-119.

Falk, J., and K. Halmi, "Amenorrhea in Anorexia Nervosa: Examination of the Critical Body Weight Hypothesis," Biol Psychiatry, 17, 1982, pp. 799-806.

Farrington, C., J. Nash, et al., "Case Series Analysis of Adverse Reactions to Vaccines: A Comparative Evaluation," Am J Epidemiology, 143, 1996, pp. 1165-1173.

Fatranska, M., M. Vargova, et al., "Circadian Susceptibility Rhythms to Some Organophosphate Compounds in the Rat," Chronobiologia, 5, 1978, pp. 39-44.

FDA, personal communication with Stuart Nightingale, Brian Malkin, and others regarding PB, 1997.

Federal Register, "Accessibility to New Drugs for Use in Military and Civilian Exigencies When Traditional Human Efficacy Studies Are Not Feasible; Determination Under the Interim Rule That Informed Consent Is Not Feasible for Military Exigencies; Request for Comments," Federal Register, 62(147), 1997, pp. 40996-41001.

Feldt-Rasmussen, B., K. Gefke, et al., "Effect of a Mixture of Pyridostigmine and Atropine on Forced Expiratory Volume and Serum Cholinesterase Activity in Normal Subjects," Br J Anaesth, 57, 1985, pp. 204-207.

Felix, R., and E. D. Levin, "Nicotinic Antagonist Administration into the Ventral Hippocampus and Spatial Working Memory in Rats," Neuroscience, 81(4), 1997, pp. 1009-1017.

Feng, H., A. Rogers, et al., "Recovery of Esterases at Muscle Endplates Inactivated by DFP," J Cell Biol, 59, 1973, p. 98a.

Fenichel, G., W.-D. Dettbarn, et al., "An Experimental Myopathy Secondary to Excessive Acetylcholine Release," Neurology, 24, 1974, pp. 41-45.

Fenichel, G., W. Kibler, et al., "Chronic Inhibition of Cholinesterase as a Cause of Myopathy," Neurology, 22, 1972, pp. 1026-1033.

Fenichel, G., W. Kibler, et al., "The Effect of Immobilization and Exercise on Acetylcholine-Mediated Myopathies," Neurology, 24, 1974, pp. 1086-1090.

Fiedler, N., H. Kipen, et al., "Chemical Sensitivities and the Gulf War: Department of Veterans Affairs Research Center in Basic and Clinical Science Studies of Environmental Hazards," Regulatory Toxicology and Pharmacology, 24, 1996, pp. S129-S138.

Field, L., "Toxic Alopecia Caused by Pyridostigmine Bromide," Arch Dermatol, 116, 1980, p. 1103.

Field Manual: Treatment of Chemical Agent Casualties and Conventional Military Chemical Injuries, Washington, D. C.: Departments of the Army, the Navy, and the Air Force, 1990.

Field Manual: Treatment of Chemical Agent Casualties and Conventional Military Chemical Injuries, Washington, D. C.: Departments of the Army, the Navy, and the Air Force, and Commandant, Marine Corps, 1995.

Findley, L., M. Fabrizio, et al., "Severity of Sleep Apnea and Automobile Crashes," New Engl J Med, 320(13), 1989, pp. 868-869.

Findley, L., M. Unverzagt, et al., "Vigilance and Automobile Accidents in Patients with Sleep Apnea or Narcolepsy," Chest, 108(3), 1995, pp. 619-624.

Findley, L., M. Unverzagt, et al., "Automobile Accidents Involving Patients with Obstructive Sleep Apnea," Am Rev of Respiratory Disease, 138(2), 1988, pp. 337-340.

Findley, L., J. Weiss, et al., "Drivers with Untreated Sleep Apnea. A Cause of Death and Serious Injury," Arch of Intern Med 151(7), 1991, pp. 1451-1452.

Fischer, G., "Inhibierung und Restitution der Azetylcholinesterase an der motorischen Endplatte im Zwerchfell der Ratte nach Intoxikation mit Soman," Histochemie, 16, 1968, pp. 144-149.

Fischler, B., H. D'Haenen, et al., "Comparison of 99m Tc HMPAO SPECT Scan Between Chronic Fatigue Syndrome, Major Depression and Healthy Controls: An Exploratory Study of Clinical Correlates of Regional Cerebral Blood Flow," Neuropsychobiology, 34(4), 1996, pp. 175-183.

Fleming, N., S. Macres, et al., "Neuromuscular Blocking Action of Suxamethonium After Antagonism of Vecuronium by Edrophonium, Pyridostigmine or Neostigmine," Brit J Anaesth, 77, 1996, pp. 492-495.

Flemons, W., and W. Tsai, "Quality of Life Consequences of Sleep-Disordered Breathing," J Allergy and Clin Immunology, 99(2), 1997, pp. S750-S756.

Flores, C., S. Rogers, et al., "A Subtype of Nicotinic Cholinergic Receptor in Rat Brain Is Composed of Alpha4 and §2 Subunits and Is Up-Regulated by Chronic Nicotine Treatment," Mol Pharmacol, 41, 1992, pp. 31-37.

Forbes, A., "Smoking and Inflammatory Bowel Disease," Eur J Gastroenterol Hepatol, 8(8), 1996, pp. 761-763.

FORSCOM Operations Support Directive, "Pyridostigmine Pretreatment for Nerve Agents," FORSCOM, 1990.

Forster, E. M., J. A. Barber, et al., "Effect of Pyridostigmine Bromide on Acceleration Tolerance and Performance," Aviat Space Environ Med, February 1994, pp. 110-116.

Foulds, J., J. Stapleton, et al., "Cognitive Performance Effects of Subcutaneous Nicotine in Smokers and Never-Smokers," Psychopharmacology, 127(1), 1996, pp. 31-38.

Fraga, C., P. Oteiza, et al., "Effects of Aluminium on Brain Peroxidation," Toxicol Lett, 51, 1990, pp. 213-219.

Francesconi, R., M. Bosselaers, et al., "Pyridostigmine, 2-PAM and Atropine: Effects on the Ability to Work in the Heat," U.S. Army Research Institute of Environmental Medicine, 1987.

Francesconi, R., R. Hubbard, and M. Mager, "Effects of Pyridostigmine on Ability of Rats to Work in the Heat," J Appl Physiol, 56(4), 1984, pp. 891-895.

Freedman, A., H. Kaplan, et al., Comprehensive Text Book of Psychiatry, Baltimore: Williams and Wilkins, 1978, Vol. 1, pp. 1110-1111.

French, J., American Epilepsy Society meeting, Boston, Mass., 1997.

French, M., J. Wetherell, et al., "The Reversal by Pyridostigmine of Neuromuscular Block Produced by Soman," J Pharm Pharmacol, 31, 1979, pp. 290-294.

Fried, F., and P. Malek-Ahmadi, "Bromism: Recent Perspectives," South Med J, 68, 1975, pp. 220-222.

Friedman, A., D. Kaufer, et al., "Pyridostigmine Brain Penetration Under Stress Enhances Neuronal Excitability and Induces Early Immediate Transcriptional Response," Nature Medicine, 2, 1996, pp. 1382-1384.

Friedman, A., D. Kaufer, et al., "Cholinergic Excitation Induces Activity-Dependent Electrophysiological and Transcriptional Responses in Hippocampal Slices," Journal de Physiologie, 92(3-4), 1998, pp. 329-335.

Friedman, M., letter regarding breach of conditions for waiver of informed consent, Washington, D. C.: FDA, 1997.

Fukuda, K., R. Nisenbaum, et al., "Chronic Multisystem Illness Affecting Air Force Veterans of the Gulf War," JAMA, 280, 1998, pp. 981-988.

Furlong, C., R. Richter, et al., "Spectrophotometric Assays for the Enzymatic Hydrolysis of the Active Metabolites of Chlorpyrifos and Paration by Plasma Paraoxonase/Arylesterase," Analyt Biochem, 180, 1989, pp. 242-247.

Gaff, G., M. Rand, et al., "A Rapid Screening Test for Bromism," Medical J of Australia, 1969, pp. 967-969.

Gall, D., "The Use of Therapeutic Mixtures in the Treatment of Cholinesterase Inhibition," Fundam Appl Toxicol, 1, 1981, pp. 214-216.

Galynker, I. I., J. Weiss, et al., "ECT Treatment and Cerebral Perfusion in Catatonia," J Nucl Med, 38(2), 1997, pp. 251-254.

Gawron, V., "The Effect of Pyridostigmine Bromide on Inflight Aircrew Performance," USAF School of Aerospace Medicine, Brooks AFB, Tex., 1987.

Gebbers, J., M. Lotscher, et al., "Acute Toxicity of Pyridostigmine in Rats: Histological Findings," Arch Toxicol, 58, 1986, pp. 271-275.

Geldmacher-von Mallinckrodt, M., and T. Diepgen, "The Human Serum Paraoxonase-Polymorphism and Specificity," Toxicol Environ Chem, 18, 1988, pp. 79-196.

Geller, I., R. Hartmann, et al., "Acute Soman Effects in the Juvenile Baboon: Effects on a Match-to-Sample Discrimination Task and on Total Blood Acetylcholinesterase," Pharmacol Biochem Behav, 22, 1985, pp. 961-966.

Gentry, M., "The Metabolism of Proposed Nerve Agent Pretreatment, Pyridostigmine Bromide," in J. King, ed., Medical Defense Bioscience Review: Proceedings, U.S. Army Medical Research and Materiel Command, 1996, Vol. 2, pp. 1272-1283.

Gentry, M., N. Bitsko, et al., Pyridostigmine Inhibition of Acetylcholinesterase and Phenotyping of Butyrylcholinesterase: A Comparison in Gulf War Veterans and Normal Controls, CB Medical Treatment Symposium, Spiez, Switzerland: NC-Laboratory, 1996.

Gentry, M., S. Powell, et al., "In Vitro Pyridostigmine Inhibition of Red Cell Acetylcholinesterase: A Comparison in Gulf War Veterans and Normal Controls," Medical Defense Bioscience Review, U.S. Army Medical Research and Materiel Command, 1992.

George, S., and A. Balasubramanian, "The Aryl Acylamidases and Their Relationship to Cholinesterases in Human Serum, Erythrocyte and Liver," Eur J Biochem, 2, 1981, pp. 177-186.

Georguieff, M., M. Lefloch, et al., "Nicotinic Effect of Acetylcholine on the Release of Newly Synthesized 3H Dopamine in Rat Striatal Slices and Cat Caudate Nucleus," Brain Res, 106, 1976, p. 117.

Gerner, R., "Bromism from Over-the-Counter Medications," Am J Psychiatry, 135, 1978, p. 1428.

Gershon, S., and F. Shaw, "Psychiatric Sequelae of Chronic Exposure to Organophosphorus Insecticides," Lancet, i, 1961, pp. 1371-1374.

Geschwind, S., and B. A. Golomb, A Review of the Scientific Literature As It Pertains to Gulf War Illnesses, Vol. 8: Pesticides, Santa Monica, Calif.: RAND, MR-1018/8, forthcoming.

Ghatan, P. H., M. Ingvar, et al., "Cerebral Effects of Nicotine During Cognition in Smokers and Non-Smokers," Psychopharmacol, 136(2), 1998, pp. 178-189.

Ghigo, E., M. Nicolosi, et al., "Growth Hormone Secretion in Alzheimer's Disease: Studies with Growth Hormone-Releasing Hormone Alone and Combined with Pyridostigmine or Arginine," Dementia, 4, 1993, pp. 315-320.

Ghigo, E., S. Goffi, et al., "A Neuroendocrinological Approach to Evidence an Impairment of Central Cholinergic Function in Aging," J Endocrinol Invest, 15, 1992, pp. 665-670.

Ghoneim, M., and S. Mewaldt, "Effects of Diazepam and Scopolamine on Storage, Retrieval and Organizational Processes in Memory," Psychopharmacologia (Berl), 44, 1975, p. 257.

Ghoneim, M., and S. Mewaldt, "Studies on Human Memory: The Interactions of Diazepam, Scopolamine, and Physostigmine," Psychopharmacology, 52, 1977, p. 1.

Gillies, J., and J. Allen, "Effects of Neostigmine and Pyridostigmine at the Neuromuscular Junction," Clin Exp Neurol, 14, 1977, pp. 271-279.

Gillin, J., L. Sutton, et al., "The Cholinergic Rapid Eye Movement Induction Test with Arecoline in Depression," Arch Gen Psychiatry, 48, 1991, pp. 264-270.

Girgis, M., "Biochemical Patterns in Limbic System Circuitry: Biochemical-Electrophysiological Interactions Displayed by Chemitrode Techniques," The Limbic System: Functional Organization and Clin Disorders, New York: Raven Press, 1986, pp. 55-65.

Giustina, A., S. Bossoni, et al., "Effect of Pretreatment with Pyridostigmine on the Thyrotropin Response to Thyrotropin-Releasing Hormone in Patients with Cushing's Disease," Horm Metab Res, 24, 1992, pp. 248-250.

Giustina, A., E. Bresciani, et al., "Effect of Pyridostigmine on the Growth Hormone Response to Growth-Hormone-Releasing Hormone in Lean and Obese Type II Diabetic Patients," Metabolism, 43(7), 1994, pp. 893-898.

Gizurarson, S., "Optimal Delivery of Vaccines. Clinical Pharmacokinetic Considerations," Clinical Pharmacokinetics, 30, 1996, pp. 1-15.

Glass-Marmor, L., and R. Beitner, "Effects of Carbamylcholine and Pyridostigmine on Mitochondrial-Bound Hexokinase in Skeletal Muscle and Heart," Biochemical and Molecular Medicine, 57, 1996, pp. 67-70.

Gleadle, R., K. Kemp, and A. Wetherell, "A Study of the Effects of Three Weeks' Treatment with Pyridostigmine Bromide on Men Undergoing Moderate to Strenuous Physical Exercise," Technical Note 568, Chemical Defence Establishment, Porton Down, U.K., March 1983a.

Gleadle, R., K. Kemp, and A. Wetherell, "Three Studies of the Effects of Four Weeks' Treatment with Pyridostigmine Bromide 3x30 mg Daily," Technical Note 585, Chemical Defence Establishment, Porton Down, U.K., September 1983b.

Gleadle, R., K. Kemp, et al., "The Effect on Man of Four Weeks' Treatment of Pyridostigmine Bromide (3x30 mg p.o. Daily)," Technical Note 682 (formerly restricted), Chemical Defence Establishment, Porton Down, U.K., 1985.

Glickson, M., A. R. Achiron, Z., et al., "The Influence of Pyridostigmine Administration on Human Neuromuscular Functions--Studies in Healthy Human Subjects," Fundam Appl Toxicol, 16, 1991, pp. 288-298.

Glover, V., J. Jarman, and M. Sandler, "Migraine and Depression: Biological Aspects," J Psychiatric Res, 27(2), 1993, pp. 223-231.

Gold, D., S. Rogacz, et al., "Rotating Shift Work, Sleep, and Accidents Related to Sleepiness in Hospital Nurses," Am J Public Health, 82(7), 1992, pp. 1011-1014.

Goldman, G., S. Evans, et al., "Neural Regulation of Acetylcholine Receptor Gene Expression," Ann NY Acad Sci, 505, 1987, pp. 286-300.

Goldstein, G., S. Beers, et al., "A Preliminary Neuropsychological Study of Persian Gulf Veterans," JINS, 2, 1996, pp. 001-004.

Golomb, B., "Are Placebos Bearing False Witness?" Chemistry and Industry, 1995, p. 900.

Golomb, B., A Review of the Scientific Literature As It Pertains to Gulf War Illnesses, Vol. 3: Immunizations, Santa Monica, Calif.: RAND, MR-1018/3, forthcoming.

Goodman, J., F. Kellogg, et al., "Decrease in Serum Cholesterol with Surgical Stress," Cal Med, 97(5), 1962, pp. 278-280.

Gordon, J., R. Inns, et al., "The Delayed Neuropathic Effects of Nerve Agents and Some Other Organophosphorus Compounds," Arch Toxicol, 52, 1983, pp. 71-82.

Gordon, J., L. Leadbeater, et al., "The Protection of Animals Against Organophosphate Poisoning by Pretreatment with a Carbamate," Toxicol Appl Pharmacol, 43, 1978, pp. 207-216.

Gordon, J., M. Maidment, and L. Leadbeater, "Carbamate Prophylaxis in the Treatment of Nerve Agent Poisoning," Chemical Defence Establishment, Porton Down, U.K., 1974.

Gordon, V., "Identification of Gulf War Syndrome: Methodological Issues and Medical Illnesses (letter)," JAMA, 278(5), 1997, p. 383.

Gots, R., T. Hamosh, et al., "Multiple Chemical Sensitivities: A Symposium on the State of the Science," Regulatory Toxicology and Pharmacology, 18, 1993, pp. 61-78.

Gouge, S., D. Daniels, et al., "Exacerbation of Asthma After Pyridostigmine During Operation Desert Storm," Military Medicine, 159, 1994, pp. 108-111.

Grabenstein, J., "Drug Interactions Involving Immunologic Agents. Part I. Vaccine-Vaccine, Vaccine-Immunoglobulin, and Vaccine-Drug Interactions," Drug Intelligence and Clin Pharmacy, 24, 1990, pp. 67-81.

Grady, E., M. Carpenter, et al., "Rheumatic Findings in Gulf War Veterans," Arch Intern Med, 158, 1998, pp. 367-371.

Graham, C., Oral Dose Effects of Pyridostigmine on Human Performance, 4th Annual Chemical Defense Bioscience Review, Fort Detrick, Md., 1984.

Granacher, R., and R. Baldessarini, "Physostigmine: Its Use in Acute Anticholinergic Syndrome with Antidepressant and Antiparkinson Drugs," Arch Gen Psychiatry, 32, 1975, p. 375.

Grando, S., R. Horton, et al., "A Nicotinic Acetylcholine Receptor Regulating Cell Adhesion and Motility Is Expressed in Human Keratinocytes," J Investigative Dermatology, 105(6), 1995, pp. 774-781.

Grant, L., D. Coscina, et al., "Muricide After Serotonin-Depleting Lesions of Midbrain Raphe Nuclei," Pharmacol Biochem Behav, 1, 1973, pp. 77-80.

Grauer, E., D. Ben Nathan, et al., Cholinesterase Inhibitors Increase Blood-Brain Barrier (BBB) Permeability: Neuroinvasion of a Noninvasive Sindbis Virus as a Marker for BBB Integrity, 1996 Medical Defense Bioscience Review, U.S. Army Medical Research and Materiel Command, 1996.

Gray, G. C., B. D. Coate, et al., "The Postwar Hospitalization Experience of U.S. Veterans of the Persian Gulf War," New Engl J Med, 335(20), 1996, pp. 1505-1513.

Grayston, J. T., C. C. Kuo, et al., "Chlamydia Pneumoniae, Strain TWAR and Atherosclerosis," Eur Heart J, 14, 1993, Supplement K, pp. 66-71.

Green, J. T., G. A. Thomas, et al., "Nicotine Enemas for Active Ulcerative Colitis--A Pilot Study," Aliment Pharmacol Ther, 11(5), 1997, pp. 859-863.

Greig, M., and W. Holland, "Increased Permeability of Hemoencephalic Barrier Produced by Physostigmine and Acetylcholine," Science, 110, 1949, p. 237.

Griffel, L., and K. M. Das, "Nicotine and Ulcerative Colitis," Natl Med J India, 7(5), 1994, pp. 222-223.

Grob, D., and A. Harvey, "The Effects and Treatment of Nerve Gas Poisoning," Am J Med, 24, 1953, pp. 52-63.

Gryboski, J., D Weinstein, et al., "Toxic Encephalopathy Apparently Related to Use of an Insect Repellent," New Engl J Med, 264, 1961, pp. 289-291.

Gulflink, "U.S. Troop Exposure During Khamisiyah Demolitions Not Found at Dangerous Levels,", 1997.

Gunderson, C., C. Lehmann, et al., "Nerve Agents: A Review," Neurology, 42, 1992, pp. 946-950.

Gupta, R., G. Patterson, et al., "Mechanisms of Toxicity and Tolerance to Diisopropylphosphorofluoridate at the Neuromuscular Junction of the Rat," Toxicol Appl Pharmacol, 84, 1986, pp. 541-550.

Gurba, P., and R. Richardson, "Partial Characterization of Neurotoxic Esterase of Human Placenta," Toxicol Lett, 15, 1983, pp. 13-17.

Gurfinkel, E., G. Bozovich, et al., "Randomized Trial of Roxithromycin in Non-Q-Wave Coronary Syndromes: ROXIS Pilot Study," Lancet, 350, 1997, pp. 404-407.

Guslandi, M., and A. Tittobello, "Steroid-Sparing Effect of Transdermal Nicotine in Ulcerative Colitis," J Clin Gastroenterol, 18(4), 1994, pp. 347-348.

Guslandi, M., and A. Tittobello, "Pilot Trial of Nicotine Patches as an Alternative to Corticosteroids in Ulcerative Colitis," J Gastroenterol, 31(4), 1996, pp. 627-629.

Gutmann, L., and R. Besser, "Organophosphate Intoxication: Pharmacologic, Neurophysiologic, Clinical and Therapeutic Considerations," Seminars in Neurology, 10(1), 1990, pp. 46-51.

Gutteridge, J., G. Quinlan, et al., "Aluminium Salts Accelerate Peroxidation of Membrane Lipids Stimulated by Iron Salts," Biochim Biophys Acta, 835, 1985, pp. 441-447.

Haddad, P., "Newer Antidepressants and the Discontinuation Syndrome," J of Clin Psychiatry, 58, 1997, Supplement 7, pp. 17-22.

Haley, R., personal communication, 1997 and 1998a.

Haley, R., "Point: Bias from the `Healthy Warrior Effect' and Unequal Follow-Up in Three Government Studies of Health Effects of the Gulf War," Am J Epidemiol, 148(4), 1998b, pp. 334-338.

Haley, R., "Counterpoint: Haley Replies," Am J Epidemiol, 148(4), 1998c, pp. 334-338.

Haley, R., and T. Kurt, "Self-Reported Exposure to Neurotoxic Chemical Combinations in the Gulf War: A Cross-Sectional Epidemiologic Study," JAMA, 277(3), 1997, pp. 231-237.

Haley, R., J. Hom, et al., "Evaluation of Neurologic Function in Gulf War Veterans," JAMA, 277(3), 1997, pp. 223-230.

Haley, R., T. Kurt, and J. Hom, "Is There a Gulf War Syndrome? Searching for Syndromes by Factor Analysis of Symptoms," JAMA, 277(3), 1997, pp. 215-222.

Hallak, M., and E. Giacobini, "Physostigmine, Tacrine and Metrifonate: The Effect of Multiple Doses on Acetylcholine Metabolism in Rat Brain," Neuropharmacology, 28, 1989, pp. 199-206.

Halliwell, B., and J. Gutteridge, "Oxygen Radicals and the Nervous System," TINS, 8, 1985, pp. 22-26.

Hamden, J., open letter to Gen. H. Norman Schwarzkopf, 1997.

Handbook on the Medical Aspects of NBC Defensive Operations, Section V, "Nerve Agent Pyridostigmine Pretreatment," accessed from Internet, 1997.

Handforth, A., C. M. DeGiorgio, et al., "Vagus Nerve Stimulation Therapy for Partial-Onset Seizures: A Randomized Active-Control Trial," Neurology, 51(1), 1998, pp. 48-55.

Hane, D., "Acute Toxicity Studies in Mice, Rats, Rabbits, and Dogs with Pyridostigmine Bromide (Ro 1-5130) and Ro1-5237/000," Nutley, N.J., Roche Laboratories (internal report), 1977.

Hanes, F., and A. Yates, "An Analysis of 400 Instances of Chronic Bromide Intoxication," Southern Med J, 31, 1938, pp. 667-671.

Hanin, I., "The Gulf War, Stress and a Leaky Blood-Brain Barrier," Nature Medicine, 2(12), 1996, pp. 1307-1308.

Haraldsson, P., C. Carenfelt, et al., "Clinical Symptoms of Sleep Apnea Syndrome and Automobile Accidents," J of Oto-Rhino-Laryngology and Its Related Specialties, 52(1), 1990, pp. 57-62.

Haraldsson, P., C. Carenfelt, et al., "Does Uvulopalatopharyngoplasty Inhibit Automobile Accidents?" Laryngoscope, 105(6), 1995, pp. 657-661.

Harden, C., American Epilepsy Society meeting, Boston, Mass., 1997.

Harden, C. L., A. Jacobs, et al., "Effect of Menopause on Epilepsy," American Epilepsy Society meeting, Boston, Mass., December 7-10, 1997, Epilepsia, 38, Supplement 8, 133-134.

Harder, J. A., H. F. Baker, et al., "The Role of the Central Cholinergic Projections in Cognition: Implications of the Effects of Scopolamine on Discrimination Learning by Monkeys," Brain Res Bull, 45(3), 1998, pp. 319-326.

Hardman, J., L. Limbird, et al., eds., Goodman & Gilman's the Pharmacological Basis of Therapeutics, New York: McGraw-Hill, 1996.

Harenko, A., "Irreversible Cerebello-Bulbar Syndrome as the Sequela of Bromisovalum Poisoning," Ann Med Int Fenn, 56, 1967, pp. 29-36.

Harik, S., and R. Kalaria, "Blood-Brain-Barrier Abnormalities in Alzheimer's Disease," Ann NY Acad Sci, 640, 1991, pp. 47-52.

Harris, L., B. Talbot, et al., "Oxime Induced Decarbamylation of Pyridostigmine Inhibited Acetylcholinesterase," Proc West Pharmacol Soc, 28, 1985, pp. 281-285.

Harris, L., B. Talbot, et al., "Oxime-Induced Decarbamylation and Atropine/Oxime Therapy of Guinea Pigs Intoxicated with Pyridostigmine," Life Sci, 40, 1987, pp. 577-583.

Harris, L., W. Lennox, et al., "Toxicity of Anticholinesterases: Interaction of Pyridostigmine and Physostigmine with Soman," Drug Chem Toxicol, 7, 1984, pp. 507-526.

Harris, L. W., B. G. Talbot, et al., "The Relationship Between Oxime-Induced Reactivation of Carbamylated Acetylcholinesterase and Antidotal Efficacy against Carbamate Intoxication," Toxicol Appl Pharmacol, 98(1), 1989, pp. 128-133.

Haubrich, D. R., and W. D. Reid, "Effects of Pilocarpine or Arecoline Administration on Acetylcholine Levels and Serotonin Turnover in Rat Brain," J Pharmacol and Exp Therapeutics, 181(1), 1972, pp. 19-27.

Hawkins, R., D. Kripke, et al., "Circadian Rhythm of Lithium Toxicity in Mice," Psychopharmacology (Berl), 56, 1978, pp. 113-114.

Hayward, I., H. Wall, et al., "Decreased Brain Pathology in Organophosphate Exposed Rhesus Monkeys Following Benzodiazepine Therapy," J Neurological Sci, 98, 1990, pp. 99-106.

Health Services, Office of the Surgeon General, "Pyridostigmine Bromide (PB) Use in Operations Desert Shield and Desert Storm (ODS)," October, 2, 1996.

Heick, H., R. Shipman, et al., "Reye-Like Syndrome Associated with Use of Insect Repellent in a Presumed Heterozygote for Ornithine Carbaryl Transferase Deficiency," J Pediatr, 97, 1980, pp. 471-473.

Hein, H., D. Kirsten, et al., "Nicotine as Therapy of Obstructive Sleep Apnea?" Pneumologie, 49, 1995, Supplement 1, pp. 185-186.

Heinemann, S., G. Asouline, et al., "Molecular Biology of the Neural and Muscle Nicotinic Acetylcholine Receptors," in S. Heinemann and J. Patrick, eds., Molecular Neurobiology: Recombinant DNA Approaches, New York: Plenum Press, 1987.

Hennis, P., R. Cronnelly, et al., "Metabolites of Neostigmine and Pyridostigmine Do Not Contribute to Antagonism of Neuromuscular Blockade in the Dog," Anesthesiology, 61, 1984, pp. 534-539.

Hery, F. S. Burgoin, et al., "Control of the Release of Newly Synthesized 3H-5-Hydroxytryptamine by Nicotinic and Muscarinic Receptors in Rat Hypothalmic Slices, Naunyn-Schmiedeberg's Archives of Pharmacol, 296(2), 1977, pp. 91-97.

Heuser, G., I. Mena, et al., "Neurospect Findings in Patients Exposed to Neurotoxic Chemicals," Toxicol Ind Health, 10(4/5), 1994, pp. 561-571.

Hide, D., S. Matthews, et al., "Allergen Avoidance in Infancy and Allergy at 4 Years of Age," Allergy, 51, 1996, pp. 89-93.

Hilborne, L., and B. Golomb, A Review of the Scientific Literature As It Pertains to Gulf War Illnesses, Vol. 1: Infectious Diseases, Santa Monica, Calif.: RAND, MR-1018/1, forthcoming.

Hill, D., and N. Thomas, "Reactivation by 2-PAM Cl of Human Red Blood Cell Cholinesterase Poisoned in Vitro by Cyclohexylmethylphosphonofluoridate (GF)," Edgewood Arsenal, Md.: Medical Research Laboratory, 1969.

Hillhouse, E., J. Burden, et al., "The Effect of Various Putative Neurotransmitters on the Release of Corticotrophin Releasing Hormone from the Hypothalamus of the Rat in Vitro. I. The Effect of Acetylcholine and Noradrenaline," Neuroendocrinology, 17, 1975, p. 1.

Hitzig, P., "Fen/Phen and Gulf War Syndrome,", accessed 1997.

Holinger, P., and E. Klemen, "Violent Deaths in the United States, 1900-1975: Relationships Between Suicide, Homicide and Accidental Deaths," Soc Sci Med, 16(22), 1982, pp. 1929-1938.

Holladay, M. W., J. T. Wasicak, et al., "Identification and Initial Structure-Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-Chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting Via Neuronal Nicotinic Acetylcholine Receptors," J Med Chem, 41(4), 1998, pp. 407-412.

Holmes, J., "Organophosphorus Insecticides in Colorado," Arch Environ Health, 9, 1964, pp. 445-453.

Hood, L., "Myasthenia Gravis: Regimens and Regime-Associated Problems in Adults," J Neurosci Nurs, 22, 1990, pp. 358-364.

Hom, J., R. Haley, et al., "Neuropsychological Correlates of Gulf War Syndrome," Arch Clin Neuropsychol, 12(6), 1997, pp. 531-544.

Horowitz, B., "Bromism from Excessive Cola Consumption," Clinical Toxicology, 35(3), 1997, pp. 315-320.

Hubble, J. P., T. Cao, et al., "Risk Factors for Parkinson's Disease," Neurology, 43(9), 1993, pp. 1693-1697.

Hubert, M., and D. Lison, "Study of Muscular Effects of Short-Term Pyridostigmine Treatment in Resting and Exercising Rats," Human and Experimental Toxicology, 14, 1995, pp. 49-54.

Hudson, C., "The Effects of Pyridostigmine and Physostigmine on the Cholinergic Synapse," Fort Detrick, Md.: U.S. Army Medical Research and Development Command, 1985.

Hudson, C., J. Rash, et al., "Neostigmine-Induced Alterations at the Mammalian Neuromuscular Junction. II. Ultrastructure," J of Pharmacol Exp Therapeutics, 205(2), 1978, pp. 340-356.

Hudson, C., and R. Foster, "Ultrastructural Pathology in Mammalian Skeletal Muscle Following Acute and Subacute Exposure to Pyridostigmine. Studies of Dose-Response and Recovery," 4th Annual Chemical Defense Bioscience Review, 1984, pp. 131-171.

Hudson, C., R. Foster, et al., "Neuromuscular Toxicity of Pyridostigmine Bromide in the Diaphragm, Extensor Digitorum Longus, and Soleus Muscles of the Rat," Fundam Appl Toxicol, 5, 1985, pp. S260-S269.

Hulihan-Giblin, B., M. Lumpkin, et al., "Acute Effects of Nicotine on Prolactin Release in the Rat: Agonist and Antagonist Effects of a Single Injection of Nicotine," J Pharmacol Exp Therapeutics, 252(1), 1990, pp. 15-20.

Hulihan-Giblin, B., M. Lumpkin, et al., "Effects of Chronic Administration of Nicotine on Prolactin Release in the Rat: Inactivation of Prolactin Response by Repeated Injections of Nicotine," J Pharmacol Exp Therapeutics, 252(1), 1990, pp. 21-25.

Husain, K., R. Vijayaraghavan, et al., "Delayed Neurotoxic Effect of Sarin in Mice after Repeated Inhalation Exposure," J Appl Toxicol, 13(2), 1993, pp. 143-145.

Hussain, A., and W. Ritschel, "Influence of Dimethylacetamine, N, N-Diethyl-m-Toluamide, and 1-Dodecylazacycloheptan-2-One on ex Vivo Permeation of Phosphonoformic Acid Through Rat Skin," Methods Fundam Exp Clin Pharmacol, 10, 1988, pp. 691-694.

Hyams, K., F. Hanson, et al., "The Impact of Infectious Diseases on the Health of U.S. Forces Deployed to the Persian Gulf During Operations Desert Shield and Desert Storm," Clin Infect Dis, 20(6), 1995, pp. 1497-1504.

Hyams, K., F. Wignall, et al., "War Syndromes and Their Evaluation: From the U.S. Civil War to the Persian Gulf War," Annals of Internal Medicine, 125(5), 1996, pp. 398-405.

Hyams, K. C., and F. S. Wignall, "Identification of Gulf War Syndrome: Methodological Issues and Medical Illnesses" (letter, comment), JAMA, 278(5), 1997, p. 384, pp. 385-387 (discussion).

Idriss, M., L. Aguayo, et al., "Organophosphate and Carbamate Compounds Have Pre- and Post-Junctional Effects at the Insect Glutamatergic Synapse," J Pharmacol Exp Therapeutics, 239(1), 1986, pp. 279-285.

Iidaka, T., T. Nakajima, et al., "Quantitative Regional Cerebral Flow Measured by Tc-99M HMPAO SPECT in Mood Disorder," Psychiatry Res, 68(2-3), 1997, pp. 143-154.

Inns, R., and L. Leadbeater, "The Efficacy of Bispyridinium Derivatives in Treatment of Organophosphate Poisoning in the Guinea-Pig," J Pharm Pharmacol, 35, 1983, pp. 427-433.

Institute of Medicine: Division of Health Promotion and Disease Prevention, Committee on the Evaluation of the Department of Defense Comprehensive Clinical Evaluation Program, Adequacy of the Comprehensive Clinical Evaluation Program: Nerve Agents, Washington, D.C.: National Academy Press, 1997.

Iowa Persian Gulf Study Group, "Self-Reported Illness and Health Status Among Gulf War Veterans: A Population-Based Study," JAMA, 277, 1997, pp. 238-245.

Ito, H., R. Kawashima, et al., "Hypoperfusion in the Limbic System and Prefrontal Cortex in Depression: SPECT with Anatomic Standardization Technique [see comments]," J Nucl Med, 37(3), 1996, pp. 410-414.

Ito, T., N. Akiyama, et al., "Changes in Myocardial Mitochondrial Electron Transport Activity in Rats Administered with Acetylcholinesterase Inhibitor," Biochem Biophys Res Commun, 164, 1989, pp. 997-1002.

Iwasaki, Y., N. Wakata, et al., "Parkinsonism Induced by Pyridostigmine," Acta Neurol Scand, 78, 1988, p. 236.

Izraeli, S., D. Avgar, et al., "The Effect of Repeated Doses of 30 Mg Pyridostigmine Bromide on Pilot Performance in an A-4 Flight Simulator," Aviat Space Environ Med, 61, 1990, pp. 430-432.

Jacobs, D., M. Tang, et al., "Cognitive Function in Nondemented Women Who Took Estrogen After Menopause," Neurology, 50(2), 1998, pp. 368-373.

Jamal, G., "Long Term Neurotoxic Effects of Chemical Warfare Organophosphate Compounds (Sarin)," Adverse Drug React Toxicol Rev, 14(2), 1995a, pp. 83-84.

Jamal, G., "Long Term Neurotoxic Effects of Organophosphate Compounds," Adverse Drug React Toxicol Rev, 14(2), 1995b, pp. 85-99.

Jamal, G., S. Hansen, et al., "The `Gulf War Syndrome.' Is There Evidence of Dysfunction in the Nervous System?" J of Neurology, Neurosurgery, and Psychiatry, 60, 1996, pp. 449-451.

Janowsky, D., personal communication, 1997.

Janowsky, D., A. Abrams, et al., "Lithium Administration Antagonizes Cholinergic Behavioral Effects in Rodents," Psychopharmacology (Berl), 63, 1979, pp. 147-150.

Janowsky, D., K. El-Yousef, et al., "Parasympathetic Suppression of Manic Symptoms by Physostigmine," Arch Gen Psychiatry, 28, 1973, pp. 542-547.

Janowsky, D., K. El-Yousef, et al., "Acetylcholine and Depression," Psychosomatic Medicine, 36(3), 1974, pp. 248-257.

Janowsky, D., and D. Overstreet, "Cholinergic Dysfunction in Depression," Pharmacol Toxicol, 66, 1990, pp. 100-111.

Janowsky, D., and D. Overstreet, "The Role of Acetylcholine Mechanisms in Mood Disorders," Chapter 82, in F. Bloom and D. Kupfer, eds., Psychopharmacology: The Fourth Generation of Progress, New York: Raven Press, Ltd., 1995.

Janowsky, D., D. Overstreet, et al., "Is Cholinergic Sensitivity a Genetic Marker for the Affective Disorders?" Am J Medical Genetics, 54(3), 1994, pp. 335-344.

Janowsky, D., and S. C. Risch, "Cholinomimetic and Anti Cholinergic Drugs Used to Investigate an Acetylcholine Hypothesis of Affective Disorders and Stress," Drug Dev Res, 1984, pp. 125-142.

Janowsky, D., and S. C. Risch, "Adrenergic-Cholinergic Balance and Affective Disorders," in A. Rush and K. Altschuler, eds., Depression: Basic Mechanisms, Diagnosis, and Treatment, New York: The Guilford Press, 1986.

Janowsky, D., and S. C. Risch, "Role of Acetylcholine Mechanisms in the Affective Disorders," in H. Meltzer, ed., Psychopharmacology: The Third Generation of Progress, New York: Raven Press, Ltd., 1987.

Janowsky, D., S. C. Risch, et al., "Increased Vulnerability to Cholinergic Stimulation in Affective Disorder Patients," Psychopharmacol Bull, 16, 1980, pp. 29-31.

Janowsky, D., S. C. Risch, et al., "Adrenergic-Cholinergic Balance and the Treatment of Affective Disorders," Prog Neuropsychopharmacol Biol Psychiatry, 7, 1983, pp. 297-307.

Janowsky, D., S. C. Risch, et al., "Central Cardiovascular Effects of Physostigmine in Humans," Hypertension, 7, 1985, pp. 140-145.

Janowsky, D., S. C. Risch, et al., "Effects of Physostigmine on Pulse, Blood Pressure and Serum Epinephrine Levels," Am J Psychiatry, 142, 1985, pp. 738-740.

Janowsky, D., S. C. Risch, et al., "Physostigmine-Induced Epinephrine Release in Patients with Affective Disorder," Am J Psychiatry, 143, 1986, pp. 919-921.

Janowsky, D., S. C. Risch, et al., "Cholinergic Involvement in Affective Illness," in A. Sen and T. Lee, eds., Intercellular and Intracellular Communications, 3. Receptors and Ligands in Psychiatry, New York: Cambridge University Press, 1988.

Janowsky, D., S. C. Risch, et al., "Increased Vulnerability to Cholinergic Stimulation in Affect Disorder Patients," Psychopharmacol Bull, 16, 1980, pp. 29-31.

Janowsky, D., S. C. Risch, et al., "Cholinergic Supersensitivity in Affect Disorder Patients: Behavioral and Neuroendocrine Observations," Psychopharmacol Bull, 17, 1981, pp. 129-132.

Javoy, F., Y. Agid, et al., "Changes in Neostriatal Dopamine Metabolism After Carbachol or Atropine Microinjections into the Substantia Nigra," Brain Res, 68, 1974, p. 253.

Jenson, F., L. Nielsen, et al., "Detection of the Plasma Cholinesterase K Variant Using an Amplification-Created Restriction Site," Hum Heredity, 46, 1996, pp. 26-31.

Johansson, M., E. Hellstrom-Lindahl, et al., "Steady-State Pharmacokinetics of Tacrine in Long-Term Treatment of Alzheimer Patients," Dementia, 7(2), 1996, pp. 111-117.

Johansson, U., A. Fredriksson, and P. Eriksson, "Bioallethrin Causes Permanent Changes in Behavioural and Muscarinic Acetylcholine Receptor Variables in Adult Mice Exposed Neonatally to DDT, Eur J Pharmacol, 293(2), 1995, pp. 159-166.

Johnson, M., "A Phosphorylation Site in Brain and the Delayed Neurotoxic Effect of Some Organophosphorus Compounds," Biochem J, 111, 1969, pp. 487-495.

Johnson, M., "Organophosphorus Esters Causing Delayed Neurotoxic Effects," Arch Toxicol, 34, 1975, pp. 259-288.

Johnson, M., "Improved Assay of Neurotoxic Esterase for Screening Organophosphates for Delayed Neurotoxicity Potential," Arch Toxicol, 37, 1977, pp. 113-115.

Johnson, M., "The Target for Initiation of Delayed Neurotoxicity by Organophosphorus Esters: Biochemical Studies and Toxicological Applications," Rev Biochem Toxicol, 4, 1982, p. 141.

Johnson, M., and R. Richardson, "Biochemical End Points: Neurotoxic Esterase Assay," Neurotoxicology, 4, 1983, pp. 311-320.

Joiner, R., G. Dill, et al., "Evaluating the Efficacy of Antidote Drug Combinations Against Soman or Tabun Toxicity in the Rabbit," Columbus, Ohio: Battelle Memorial Institute, 1989.

Jolly, E., R. Gleadle, et al., "Investigation of Possible Interaction Between Pyridostigmine Pretreatment and a Thermally Stressful Environment," Institute of Naval Medicine (UK), 1981.

Jones, D., W. J. Carter, et al., "Assessing Pyridostigmine Efficacy by Response Surface Modeling," Fundam Appl Toxicol, 5, 1985, pp. S242-S251.

Joo, F., and T. Varkonyi, "Correlation Between the Cholinesterase Activity of Capillaries and the Blood-Brain Barrier in the Rat," Acta Biol Acad Sci Hung, 20, 1969, pp. 359-372.

Joseph, S., "A Comprehensive Clinical Evaluation of 20,000 Persian Gulf War Veterans," Military Medicine, 162(3), 1997, pp. 149-155.

Jusko, W. J., and H. C. Ko, "Physiologic Indirect Response Models Characterize Diverse Types of Pharmacodynamic Effects" (see comments), Clin Pharmacol Therapeutics, 56(4), 1994, pp. 406-419.

Kalow, W., and N. Staron, "On Distribution and Inheritance of Atypical Forms of Human Serum Cholinesterase, as Indicated by Dibucaine Number," Can J Biochem Physiol, 35, 1957, p. 1305.

Kamal, M. A., and A. A. al-Jafari, "The Preparation and Kinetic Analysis of Multiple Forms of Human Erythrocyte Acetylcholinesterase," Prep Biochem Biotechnol, 26(2), 1996, pp. 105-119.

Kang, H., and T. Bullman, A Mortality Follow-Up Study of Persian Gulf War Veterans (Abstr), 123rd Annual Meeting of the American Public Health Association, 1995.

Kang, H., and T. Bullman, "Mortality Among US Veterans of the Persian Gulf War," New Engl J Med, 335(20), 1996, pp. 1498-1504.

Kantak, K., L. Hegstrand, et al., "Dietary Tryptophan Modulation and Aggressive Behavior in Mice," Pharmacol Biochem Behav, 12, 1980, pp. 675-679.

Kao, K. P., S. Y. Kwan, et al., "Coexistence of Parkinson's Disease and Myasthenia Gravis: A Case Report," Clin Neurol Neurosurg, 95(2), 1993, pp. 137-139.

Kaplan, J., J. Kessler, et al., "Sensory Neuropathy Associated with Dursban (Chlorpyrifos) Exposure," Neurology, 43, 1993, pp. 2193-2196.

Kare, M., "Direct Pathways to the Brain," Science, 163, 1968, pp. 952-953.

Karler, R., K. Finnegan, et al., "Blockade of Behavioral Sensitization to Cocaine and Amphetamine by Inhibitors of Protein Synthesis," Brain Res, 603, 1993, pp. 19-24.

Kato, T., S. Sugiyama, et al., "Role of Acetylcholine in Pyridostigmine-Induced Myocardial Injury: Possible Involvement of Parasympathetic Nervous System in the Genesis of Cardiomyopathy," Arch Toxicol, 63, 1989, pp. 137-143.

Kaube, H., K. L. Hoskin, and P. J. Goadsby, "Inhibition by Sumatriptan of Central Trigeminal Neurones Only After Blood-Brain Barrier Disruption," Brit J Pharmacol, 109(3), 1993, pp. 788-792.

Kaufer, D., A. Friedman, et al., "Acute Stress Facilitates Long-Lasting Changes in Cholinergic Gene Expression [see comments]," Nature, 393(6683), 1998, pp. 373-377.

Kaufer, D., A. Friedman, et al., "Anticholinesterases Induce Multigenic Transcriptional Feedback Response Suppressing Cholinergic Neurotransmission," Chemico-Biologic Interactions, 120, 1999, pp. 249-360.

Kawabuchi, M., "Neostigmine Myopathy Is a Calcium Ion-Mediated Myopathy Initially Affecting the Motor End-Plate," J Neuropathol Exp Neurol, 41, 1982, pp. 298-314.

Kawabuchi, M., M. Osame, et al., "Myopathic Changes at the End-Plate Region Induced by Neostigmine Methylsulfate," Experientia, 32, 1976, pp. 623-625.

Kayadjanian, N., S. Retaux, et al., "Stimulation by Nicotine of the Spontaneous Release of [3H]Gamma-Aminobutyric Acid in the Substantia Nigra and in the Globus Pallidus of the Rat," Brain Res, 649(1-2), 1994, pp. 129-135.

Keeler, J., "Drug Interactions of Combined Use of Nerve Agent Pretreatment with Anesthetics, Analgesics, and Other Battlefield Medications," Aberdeen Proving Ground, Md,: U.S. Army Medical Research Institute of Chemical Defense, 1988.

Keeler, J., "Interactions Between Nerve Agent Pretreatment and Drugs Commonly Used in Combat Anesthesia," Military Medicine, 155, 1990, pp. 527-533.

Keeler, J. R., C. G. Hurst, et al., "Pyridostigmine Used as a Nerve Agent Pretreatment Under Wartime Conditions," JAMA, 266(5), 1991, pp. 693-695.

Kemp, R., and A. Wetherell, "A Lab Study of the Performance of Men Taking Pyridostigmine Bromide Orally for Two Weeks," Chemical Defence Establishment, Porton Down, U.K., 1981.

Kennedy, B., D. Janowsky, et al., "Central Cholinergic Stimulation Causes Adrenal Epinephrine Release," J Clin Invest, 74, 1984, pp. 972-975.

Kennedy, P., "Oesophageal Spasm as a Side Effect of Nerve Agent Pretreatment System (letter)," J Royal Army Medical Corps, 137, 1991, pp. 152-153.

Kerenyi, S., M. Murphy, et al., "Toxic Interactions Between Repeated Soman and Chronic Pyridostigmine in Rodents," Pharmacology Biochemistry and Behavior, 37, 1990, pp. 267-271.

Ketchum, J., F. Sidell, et al., "Atropine, Scopolamine, and Ditran: Comparative Pharmacology and Antagonists in Man," Psychopharmacologia (Berl), 28, 1973, p. 121.

Khan, I. M., T. L. Yaksh, et al., "Epibatidine Binding Sites and Activity in the Spinal Cord," Brain Res, 753(2), 1997, pp. 269-282.

Kisters, K., C. Spieker, et al., "Clinical Aspects of Aluminium Metabolism and Aluminium Containing Drugs," in P. Collery, L. Poirier, et al., eds., Metal Ions in Biology and Medicine, Paris: John Libbey, 1990, pp. 320-322.

Kleinrok, Z., E. Jagiello-Wojtowicz, and M. Sieklucka, "Influence of Fluorostigmine on Some Parameters of the Catecholaminergic and Serotoninergic Systems in the Mouse Brain," Archivum Immunologiae et Therapiae Experimentalis, 23(6), 1975, pp. 769-776.

Kluwe, W., J. Chinn, et al., "Efficacy of Pyridostigmine Pretreatment Against Acute Soman Intoxication in a Primate Model," Sixth Medical Chemical Defense Bioscience Review, Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, 1987, pp. 227-234.

Koelle, G., "Protection of Cholinesterase Against Irreversible Activation by DFP in Vitro," J Pharmacol Exp Therapeutics, 88, 1946, pp. 232-237.

Koelle, G., "Histochemical Localization of Cholinesterases in the Central Nervous System of the Rat," J Pharmacol Exp Therapeutics, 106, 1952, p. 401.

Kohler, E. C., L. V. Riters, et al., "The Muscarinic Acetylcholine Antagonist Scopolamine Impairs Short-Distance Homing Pigeon Navigation," Physiol Behav, 60(4), 1996, pp. 1057-1061.

Kok, A., "REM Sleep Pathways and Anticholinesterase Intoxication: A Mechanism for Nerve Agent-Induced Central Respiratory Failure," Medical Hypotheses, 41, 1993, pp. 141-149.

Kolka, M., and L. Stephenson, "Human Temperature Regulation During Exercise After Oral Pyridostigmine Administration," Aviat Space Environ Med, 61, 1990, pp. 220-224.

Kolka, M., P. Burgoon, et al., "Multiple Dose Pyridostigmine Administration: Cardiovascular Effects at Rest During Acute Heat and Altitude Exposure," U.S. Army Research Institute of Environmental Medicine, 1991a.

Kolka, M., P. Burgoon, et al., "Red Blood Cell Cholinesterase Activity and Plasma Pyridostigmine Concentration During Single and Multiple Dose Studies," U.S. Army Research Institute of Environmental Medicine, 1991b.

Kondo, S., T. Mizuno, et al., "Effects of Penetration Enhancers on Percutaneous Absorption of Nifedipine. Comparison Between Deet and Azone," J Pharmacobiodyn, 11(2), 1988, pp. 88-94.

Koplovitz, I., "U.S. Strategy for the Evaluation of Nerve Agent Countermeasures," NATO Unclassified, undated.

Koplovitz, I., V. Gresham, et al., "Evaluation of the Toxicity, Pathology, and Treatment of Cyclohexylmethylphosphono-Fluoridate (CMFF) Poisoning in Rhesus Monkeys," Arch Toxicol, 66, 1992, pp. 622-628.

Koplovitz, I., L. Harris, et al., "Reduction by Pyridostigmine Pretreatment of the Efficacy of Atropine and 2-PAM Treatment of Sarin and VX Poisoning in Rodents," Fundam Appl Toxicol, 18, 1992, pp. 102-106.

Koplovitz, I., and J. Stewart, "A Comparison of the Efficacy of HI6 and 2-PAM Against Soman, Tabun, Sarin, and VX in the Rabbit," Toxicol Lett, 70, 1994, pp. 269-279.

Kornfeld, P., A. Samuels, et al., "Metabolism of 14C-Labeled Pyridostigmine in Myasthenia Gravis," Neurology, 20, 1970, pp. 634-641.

Kornhauser, D., B. Petty, et al., unpublished data on safety, tolerance, pharmacokinetics, and pharmacodynamics of intravenous pyridostigmine and oral doses of standard and sustained-release pyridostigmine in healthy men and influence of food on oral pyridostigmine, cited in Sidell (1990).

Korpela, M., and H. Tahti, "Effect of Organic Solvents on Human Erythrocyte Membrane Acetylcholinesterase Activity in Vitro: Toxic Interfaces of Neurones, Smoke, and Genes," Arch Toxicol Suppl, 9, 1986, pp. 320-323.

Korpela, M., H. Tahti, et al., "The Effect of Selected Organic Solvents on Intact Human Red Cell Membrane Acetylcholinesterase in Vitro," Toxicol Appl Pharmacol, 85, 1986, pp. 257-262.

Korsak, R., and M. Sato, "Effects of Chronic Organophosphate Pesticide Exposure on the Central Nervous System," Clin Toxicol, 11, 1977, pp. 83-95.

Koster, R., "Synergisms and Antagonisms Between Physostigmine and Di-Isopropyl Fluorophosphate in Cats," J Pharmacol Exp Therapeutics, 88, 1946, pp. 39-46.

Kostka, G., D. Palut, et al., "The Effect of Permethrin and DDT on the Activity of Cytochrome P-450 1A and 2B Molecular Forms in Rat Liver," Rocz Panstw Zakl Hig, 48(3), 1997, pp. 229-237.

Kostowski, W., and L. Valzelli, "Biochemical and Behavioral Effects of Lesions of Raphe Nuclei in Aggressive Mice," Pharmacol Biochem Behav, 2, 1974, pp. 277-280.

Kotler-Cope, S., J. Milby, et al., "Neuropsychological Deficits in Persian Gulf War (PGW) Veterans. A Preliminary Report (abstract)," J of the International Neuropsychological Society, 2, 1996, p. 63.

Kramer, P., and C. McClain, "Depression of Aminopyrine Metabolism by Influenza Vaccine," New Engl J Med, 305, 1981, pp. 1262-1264.

Krausz, Y., O. Bonne, et al., "Brain SPECT Imaging of Neuropsychiatric Disorders," Eur J Radiol, 21(3), 1996, pp. 183-187.

Kuffler, S., and D. Yoshikami, "The Number of Transmitter Molecules in a Quantum: An Estimate from Iontophoretic Application of Acetylcholine at the Neuromuscular Junction," J Physiol, 251, 1975, pp. 465-482.

Kuffler, S., J. Nicholls, et al., From Neuron to Brain. Sunderland, Mass.: Sinauer Associates, Inc., 1984.

Kulkarni, A., "Muricidal Block Produced by 5-Hydroxytryptophan and Various Other Drugs," Life Sci, 7, 1968, pp. 125-128.

Kunze, U., "Chronic Bromide Intoxication with a Severe Neurological Deficit," J Neurol, 213, 1976, pp. 149-152.

Laine-Cessac, P., A. Turcant, et al., "Inhibition of Cholinesterases by Histamine 2 Receptor Antagonist Drugs," Res Commun in Chem Pathol and Pharmacol, 79(2), 1993, pp. 185-193.

Lallement, G., A. Foquin, et al., "Heat Stress, Even Extreme, Does Not Induce Penetration of Pyridostigmine into the Brain of Guinea-Pigs (abstract)," U.S. Army Medical Research and Materiel Command, Bioscience Review Program Book, 1998, p. 201.

Landauer, W., "Cholinomimetic Teratogens: Studies with Chicken Embryos," Teratology, 12, 1975, pp. 125-146.

Landrigan, P., D. Graham, et al., "Environmental Neurotoxic Illness: Research for Prevention," Environmental Health Perspectives, 102, 1994, Supplement 2, pp. 117-120.

Lange, G., L. Tiersky, et al., The Relationship Between Psychiatric Diagnoses and Fatiguing Illness in Gulf War Veterans, Conference on Federally Sponsored Gulf War Veterans' Illnesses Research, June 17-19, 1998a, Pentagon City, Va.

Lange, G., L. Tiersky, et al., Pattern of Cognitive Function in Registry Gulf War Veterans: A Preliminary Study [abstract], Conference on Federally Sponsored Gulf War Veterans' Illnesses Research, June 17-19, 1998b, Pentagon City, Va.

Langenberg, J., L. De Jong, et al., "Protection of Guinea Pigs Against Soman Poisoning by Pretreatment with P-Nitrophenyl Phosphoramidates," Toxicol Appl Pharmacol, 140, 1996, pp. 444-450.

Lashner, B. A., S. B. Hanauer, and M. D. Silverstein, "Testing Nicotine Gum for Ulcerative Colitis Patients. Experience with Single-Patient Trials," Digestive Diseases and Sci, 35(7), 1990, pp. 827-832.

Laskowski, M., W. Olson, et al., "Ultrastructural Changes at the Motor End-Plate Produced by an Irreversible Cholinesterase Inhibitor," Exp Neurol, 47, 1975, pp. 290-306.

Laskowski, M., W. Olson, et al., "Initial Ultrastructural Abnormalities at the Motor End Plate Produced by a Cholinesterase Inhibitor," Exp Neurol, 57, 1977, pp. 13-33.

Lasseter, K., and D. Garg, "A Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of Pyridostigmine When Given in Single and Multiple Doses to Males and Females in Different Weight Groups," Department of the Army, 1996.

Latven, A., and A. Sloane, "A Toxicologic Appraisal of Mestinon Bromide," Darby, Pa.: Pharmacology Research, Inc. (internal report), 1954.

Leadbeater, L., R. Inns, et al., "Treatment of Poisoning by Soman," Fundam Appl Toxicol, 5, 1985, pp. S225-S231.

Leber, P., letter from Director, Division of Neuropharmacological Drug Products, Office of Drug Evaluation I, Center for Drug Evaluation and Research, to Dr. Ronald E. Clawson, Office of the Surgeon General, Department of the Army, Human Use Review and Regulatory Affairs, Fort Detrick, Md., 1994.

Lederberg, J., "Report of the Defense Science Board (DSB) Task Force on Persian Gulf War Health Effects," Washington, D.C.: Office of the Secretary of Defense, 1994.

Lee, B., T. Stelly, et al., "Inhibition of Acetylcholinesterase by Hemicholiniums, Conformationally Constrained Choline Analogues. Evaluation of Aryl and Alkyl Substituents. Comparisons with Choline and (3-Hydroxyphenyl) Trimethylammonium," Chem Res Toxicol, 5(3), 1992, pp. 411-418.

Lees-Haley, P., and R. Brown, "Biases in Perception and Reporting Following a Perceived Toxic Exposure," Perceptual and Motor Skills, 75, 1992, pp. 531-544.

Lehmann, D., C. Johnston, et al., "Synergy Between the Genes for Butyrylcholinesterase K Variant and Apolipoprotein E4 in Late-Onset Confirmed Alzheimer's Disease," Hum Mol Genet, 6, 1997, pp. 1933-1936.

Lejoyeux, M., and J. Ades, "Antidepressant Discontinuation: A Review of the Literature," J of Clin Psychiatry, 58, 1997, Supplement 7, pp. 11-16.

Lemmer, B., "Clinical Chronopharmacology: The Importance of Time in Drug Treatment," Ciba Found Symp, 183, 1995, pp. 235-247; discussion pp. 247-253.

Lena, C., and J.-P. Changeux, "Pathological Mutations of Nicotinic Receptors and Nicotine-Based Therapies for Brain Disorders," Current Opinion in Neurobiology, 7, 1997, pp. 674-682.

Lena, C., J.-P. Changeux, et al., "Evidence for `Preterminal' Nicotinic Receptors on GABAergic Axons in the Rat Interpeduncular Nucleus," J Neurosci, 13, 1993, pp. 2680-2688.

Lennox, W., L. Harris, et al., "Relationship Between Reversible Acetylcholinesterase Inhibition and Efficacy Against Soman Lethality," Life Sci, 37, 1985, pp. 793-798.

Leo, K., and J. Grace, "The Metabolism of Proposed Nerve Agent Pretreatment, Pyridostigmine Bromide," in J. King, ed., Medical Defense Bioscience Review: Proceedings, U.S. Army Medical Research and Materiel Command, 2, 1996, pp. 1272-1283.

Leonard, J., and M. Salpeter, "Agonist Induced Myopathy at the Neuromuscular Junction Is Mediated by Calcium," J Cell Biol, 82, 1979, pp. 811-819.

Leon-S, F., G. Pradilla, and Vezga, "Neurological Effects of Organophosphate Pesticides," BMJ, 313, 1996, pp. 690-691.

Leon-S, F., G. Pradilla, et al., "Multisystem Failure Atrophy, Intermediate Syndrome, Anticholinesterase Treatment and Congenital Acetylcholinesterase Deficiency: The Linkage Is Puzzling," J Toxicol Clin Toxicol, 34, 1996a, pp. 245-246.

Leon-S, F., G. Pradilla, et al., "Multiple System Organ Failure, Intermediate Syndrome, Congenital Myasthenic Syndrome, and Anticholinesterase Treatment: The Linkage Is Puzzling" (letter, comment), J Toxicol Clin Toxicol, 34(2), 1996b, pp. 245-247.

Leopold, I. H., and P. R. McDonald, "Diisopropyl Fluorophosphate (DFP) in Treatment of Glaucoma. Further Observations," Arch Ophthalmol, 40, 1948, pp. 176-186.

Lester, A., and J. Dani, Desensitization by Nicotine of Central Acetylcholine Receptors, International Symposium on the Cholinergic Synapse: Structure, Function and Regulation (3rd), University of Maryland, Baltimore, 1994.

Levey, A. I., "Muscarinic Acetylcholine Receptor Expression in Memory Circuits: Implications for Treatment of Alzheimer Disease," Proc Natl Acad Sci USA, 93(24), 1996, pp. 13541-13546.

Levi, F., S. Giacchetti, et al., "Chronomodulation of Chemotherapy Against Metastatic Colorectal Cancer. International Organization for Cancer Chronotherapy," Eur J Cancer, 31A(7-8), pp. 1264-1270.

Levin, A., and V. Byers, "Multiple Chemical Sensitivities: A Practicing Clinician's Point of View. Clinical and Immunological Research Findings," Toxicol Ind Health, 8, 1992, pp. 95-109.

Levin, E., C. Conners, et al., "Nicotine Effects on Adults with Attention-Deficit/Hyperactivity Disorder," Psychopharmacology, 123, 1996, pp. 55-63.

Levin, E. D., D. Torry, et al., "Is Binding to Nicotinic Acetylcholine and Dopamine Receptors Related to Working Memory in Rats?" Brain Res Bull, 43(3), 1997, pp. 295-304.

Levin, H., R. Rodnitzky, et al., "Anxiety Associated with Exposure to Organophosphate Compounds," Arch Gen Psychiatry, 33, 1976, pp. 225-228.

Levin, M., "Eye Disturbances in Bromide Intoxication," Amer J Ophthalmol, 50, 1960, pp. 478-483.

Levine, B., and R. Parker, "Reproductive and Developmental Toxicity Studies of Pyridostigmine Bromide in Rats," Toxicology, 69(3), 1991, pp. 291-300.

Levine, L., M. Kolka, et al., "Respiratory and Skeletal Muscle Function After Acute Pyridostigmine Bromide Administration," U.S. Army Research Institute of Environmental Medicine, 1991.

Levitzki, A., "Bacterial Adaptation, Visual Adaptation, Receptor Desensitization--A Common Link?" Trends Pharmacol Sci, 7, 1986, pp. 3-6.

Li, W.-F., L. Costa, et al., "Serum Paraoxonase Status: A Major Factor in Determining Resistance to Organophosphates," J Tox Envir Hlth, 40, 1993, pp. 337-346.

Lieske, C., R. Gepp, et al., "Cholinesterase Studies with (R) (+)-and (S) (-)-5- (1,3,3-Trimethylindolinyl)-N- (1-Phenylethyl)Carbamate," J Enzyme Inhibition, 6, 1993, pp. 283-291.

Lietman, P., and B. Petty, "Phase I Clinical Pharmacology Studies," Fort Detrick, Md.: U.S. Army Medical Research and Development Command, 1993.

Ligget, S., and C. Daughaday, "Ipratropium in Patients with COPD Receiving Cholinesterase Inhibitors," Chest, 94, 1988, pp. 210-212.

Lintern, M., M. Smith, et al., "Effect of Repeated Treatment with Pyridostigmine on Acetylcholinesterase in Mouse Muscles," Human and Experimental Toxicology, 16, 1997, pp. 158-165.

Lintern, M., M. Smith, et al., "The Effect of Repeated Treatment with Pyridostigmine on the Activity of Acetylcholinesterase Molecular Forms in Mouse Skeletal Muscle," Br J Pharmacol, 116, 1995, p. 81P.

Lintern, M., M. Smith, et al., "Effects of Pyridostigmine on Acetylcholinesterase in Different Muscles of the Mouse," Human and Experimental Toxicology, 16, 1996, pp. 18-24.

Lintern, M., J. Wetherell, et al., "Differential Recovery of AChE in Guinea Pig Muscle and Brain Regions After Soman Treatment," Human and Experimental Toxicology 17, 1998, pp. 157-161.

Lipp, J., "Effect of Diazepam upon Soman-Induced Seizure Activity and Convulsions," Electroencephalog Clin Neurophysiol, 32, 1972, pp. 557-560.

Lipp, J., "Effect of Benzodiazepine Derivatives on Soman-Induced Seizure Activity and Convulsions in the Monkey," Arch Inte Pharmacodyn, 202, 1973, pp. 244-251.

Liu, W.-F., "Acute Effects of Oral Low Doses of Pyridostigmine on Simple Visual Discrimination and Unconditioned Consummatory Action," Pharmachol Biochem Behav, 41, 1991, pp. 251-254.

Llorente, I., F. Lizcano, et al., "Cholinergic Modulation of Spontaneous Hypothalamic-Pituitary-Adrenal Activity and Its Circadian Variation in Man," J Endocrinol Metab, 81(8), 1996, pp. 2902-2907.

Loewenstein-Lichtenstein, Y., M. Schwarz, et al., "Genetic Predisposition to Adverse Consequences of Anti-Cholinesterases in `Atypical' BCHE Carriers," Nature Medicine, 1(10), 1995, pp. 1082-1084.

Lotti, M., "The Pathogenesis of Organophosphate Polyneuropathy," Crit Rev Toxicol, 21(6), 1991, pp. 465-487.

Lotti, M., S. Caroldi, et al., "Promotion of Organophosphate-Induced Delayed Polyneuropathy by Phenylmethanesulfonyl Fluoride [see comments]," Toxicol Appl Pharmacol, 108(2), 1991, pp. 234-241.

Lotti, M., and A. Moretto, "The Search for the Physiological Functions of NTE; Is NTE a Receptor?" Chem Biol Interact, 87(1-3), 1993, pp. 407-416.

Lotti, M., and A. Moretto, "Cholinergic Symptoms and Gulf War Syndrome," Nature Medicine, 1, 1995, pp. 1225-1226.

Lotti, M., A. Moretto, et al., "Inhibition of Lymphocytic Neuropathy Target Esterase Predicts the Development of Organophosphate-Induced Polyneuropathy," Arch Toxicol, 59, 1986, pp. 176-179.

Lotti, M., A. Moretto, et al., "Interactions Between Neuropathy Target Esterase and its Inhibitors and the Development of Polyneuropathy," Toxicol Appl Pharmacol, 122(2), 1993, pp. 165-171.

Lucey, J., G. Butcher, et al., "Elevated Growth Hormone Responses to Pyridostigmine in Obsessive-Compulsive Disorder: Evidence of Cholinergic Supersensitivity," Am J Psychiatry, 150(6), 1993, pp. 961-962.

Luetje, C., J. Patrick, et al., "Nicotine Receptors in the Mammalian Brain," The FASEB Journal, 4, 1990, pp. 2753-2760.

MacDonald, T., and R. Martin, "Aluminium Ion in Biological Systems," TIBS, 13, 1988, pp. 15-19.

Machade, S., and G. Robinson, "A Direct, General Approach Based on Isobolograms for Assessing the Joint Action of Drugs in Pre-Clinical Experiments," Statistics in Medicine, 13, 1994, pp. 2289-2309.

Maes, V., L. Huyghens, et al., "Acute and Chronic Intoxication with Carbromal Preparations," Clinical Toxicology, 23(4-6), 1985, pp. 341-346.

Mager, P., Multidimensional Pharmacochemistry, San Diego, Calif.: Academic Press, 1984, pp. 52-53.

Maizlish, N., "A Behavioral Evaluation of Pest Control Workers with Short Term Low Level Exposure to Organophosphate Diazinon," Am J Ind Med, 12, 1987, pp. 153-172.

Mani, A., M. S. Thomas, and A. P. Abraham, "Type II Paralysis or Intermediate Syndrome Following Organophosphorus Poisoning," J Assoc Physicians of India, 40(8), 1992, 542-544.

Marino, M., B. Schuster, et al., "Population Kinetics and Dynamics of Pyridostigmine Bromide in Man: Implications for Effectiveness in Field Units," in J. M. King, ed., US Medical Defense Bioscience Review. Proceedings, 2, Fort Detrick, Ms.: U.S. Army Medical Research and Materiel Command, May 12-16, 1996, p. 1284.

Marks, M., and A. Collins, "Effects of Chronic Nicotine Infusion on Tolerance Development and Nicotine Receptors," J Pharmacol Exp Therapeutics, 226(3), 1983, pp. 283-291.

Marks, M., J. Pauly, et al., "Nicotine Binding and Nicotinic Receptor Subunit RNA After Chronic Nicotine Treatment," J Neuroscience, 12(7), 1992, pp. 2765-2784.

Marks, M., J. Stitzel, et al., "Time-Course Study of the Effects of Chronic Nicotine Infusion on Drug Response and Brain Receptors," J Pharmacol Exp Therapeutics, 235(3), 1985, pp. 619-628.

Marks, M., L. Artman, et al., "Cholinergic Adaptations to Chronic Oxotremorine Infusion," J Pharmacol Exp Therapeutics, 218, 1981, pp. 337-343.

Marrs, T., "Organophosphate Poisoning," Pharmacol Ther, 58, 1993, pp. 51-66.

Marshall, G., L. Davis, and C. Sherbourne, A Review of the Scientific Literature As It Pertains to Gulf War Illnesses, Vol. 4: Stress, Santa Monica, Calif.: RAND, MR-1018/4, 1999.

Martin, G. R., "Pre-Clinical Pharmacology of Zolmitriptan (Zomig; formerly 311C90), a Centrally and Peripherally Acting 5HT1B/1D Agonist for Migraine," Cephalgia, Supplement 18, October 17, 1997, pp. 4-14.

Martin, H., and J. Standerwick, "The Effect of Pyridostigmine upon Exercise Ventilation and Cardiac Frequency in Healthy Men," Chemical Defence Establishment Technical Note 445, Porton Down, U.K., 1980.

Martin, R., "Bioinorganic Chemistry of Aluminum," in H. Sigel, ed., Metal Ions in Biological Systems, New York: Marcel Dekker, 1988, pp. 1-57.

Martyn, C., C. Osmond, et al., "Geographical Relations Between Alzheimer's Disease and Aluminium in Drinking Water," Lancet, 1, 1989, pp. 59-62.

Maselli, R., and C. Leung, "Analysis of Neuromuscular Transmission Failure Induced by Anticholinesterases," Ann NY Acad Sci, 1993a, pp. 402-404.

Maselli, R., and C. Leung, "Analysis of Anticholinesterase-Induced Neuromuscular Transmission Failure," Muscle and Nerve, 16, 1993b, pp. 548-553.

Mason, H., E. Waine, et al., "Aging and Spontaneous Reactivation of Human Plasma Cholinesterase Activity After Inhibition by Organophosphorus Pesticides," Human and Experimental Toxicology, 12, 1993, pp. 497-503.

Matters, D., "Disturbances of Liver Porphyrin Metabolism Caused by Drugs," Pharmacological Reviews, 19, 1967, p. 537.

Matthew, C. B., R. P. Francesconi, and R. W. Hubbard, "Physostigmine: Dose-Response Effects on Endurance and Thermoregulation During Exercise," Life Sci, 47(4), 1990, pp. 335-343.

Matthew, C. B., R. P. Francesconi, et al., "Chronic vs. Acute Carbamate Administration in Exercising Rats," Life Sci, 47(4), 1990, pp. 335-343.

Matthew, C., J. Glenn, et al., "Acute Subchronic Pyridostigmine Administration: Effects on the Anticholinergic Properties of Atropine," Proceedings of the 1993 Medical Defense Bioscience Review, 2, 1993, pp. 605-614.

Matthew, C., J. Glenn, et al., "Cholinergic Drug Interactions and Heat Tolerance," Life Sci, 54(17), 1994, pp. 1237-1245.

Matthew, C. B., R. W. Hubbard, and R. P. Francesconi, "A Heat-Stressed Rat Model to Determine Relative Anticholinergic and Anticholinesterase Drug Potency," Aviat Space Environ Med, 57(11), 1986, pp. 1061-1065.

Matthew, C. B., R. W. Hubbard, and R. P. Francesconi, "Atropine, Diazepam, and Physostigmine: Thermoregulatory Effects in the Heat-Stressed Rat," Life Sci, 44(25), 1989, pp. 1921-1927.

Matthew, C. B., R. W. Hubbard, et al., "Carbamate-Induced Performance and Thermoregulatory Decrements Restored with Diazepam and Atropine," Aviat Space Environ Med, 58(12), 1987, pp. 1183-1187.

Matthew, C. B., R. W. Hubbard, et al., "Carbamates, Atropine, and Diazepam: Effects on Performance in the Running Rat," Life Sci, 42(20), 1988, pp. 1925-1931.

Matyszak, M. K., and V. H. Perry, "Demyelination in the Central Nervous System Following a Delayed-Type Hypersensitivity Response to Bacillus Calmette-Guerin," Neuroscience, 64(4), 1995, pp. 967-977.

Maurissen, J., "Psychophysical Testing in Human Populations Exposed to Neurotoxicants," Neurobehavioral Toxicology and Teratology, 7, 1985, pp. 309-317.

Maxwell, D., K. Brecht, et al., "Comparison of Antidote Protection Against Soman by Pyridostigmine, HI-6 and Acetylcholinesterase," J Pharmacol Exp Therapeutics, 264(3), 1993, pp. 1085-1089.

Maycock, G., "Sleepiness and Driving: The Experience of UK Car Drivers," J of Sleep Res 5(4), 1996, pp. 229-237.

McCabe, W., J. Hammarsten, et al., "Elevations of Serum Cholesterol in Man in Association with Life Stress and Independent of Diet and Exercise," Abstract, J. Lab & Clin Med, 54, 1959, p. 922.

McCain, W. C., "Acute Oral Toxicity Study of Pyridostigmine Bromide, Permethrin, and DEET in the Laboratory Rat," J Toxicol and Env Health, 50, 1997, pp. 113-124.

McConnell, R., A. Fidler, et al., "Health Hazard Evaluation Determination Report," NIOSH, U.S. Department of Health and Human Services, 1986.

McConnell, R., M. Keifer, et al., "Elevated Tactile Vibration Threshold Among Workers Previously Poisoned with Methamidofos and Other Organophosphate Pesticides," Am J Ind Med, 25, 1994, pp. 325-334.

McEvoy, G., ed., AHFS Drug Information, Bethesda, Md.: American Society of Hospital Pharmacists, 1991.

McEwen, B., and R. Sapolsky, "Stress and Cognitive Function," Curr Opin Neurobiol, 5, 1995, pp. 205-216.

McGarrigle, R., N. Adams, et al., "The Effectiveness of a Carbamate in Prophylaxis Against Nerve Agent in Dogs and Monkeys," Aberdeen Proving Ground, Md.: Chemical Research Development and Engineering Center, 1976.

McGehee, D., M. Heath, et al., "Nicotine Enhancement of Fast Excitatory Synaptic Transmission in CNS by Presynaptic Receptors," Science, 269(5231), 1995, pp. 1692-1696.

McKee, W., and B. Wollcott, "Report on Exposures of Unprotected Men and Rabbits to Low Concentrations of Nerve Gas Vapour," Porton Technical Paper 143, 1949.

McNall, P., B. Wolfson, et al., "Use of Pyridostigmine for the Reversal of Neuromuscular Blockade," Anesthesia and Analgesia . . . Current Researches, 48(6), 1969, pp. 1026-1032.

McPhail, R., "Studies on the Flavor Aversions Induced by N-Substituted Carbamates and by Alkyl-Tin Compounds," Toxicologist, 1, 1981, p. 44.

McPhillips, J., "Altered Sensitivity to Drugs Following Repeated Injections of a Cholinesterase Inhibitor in Rats," Toxicol Appl Pharmacol, 14, 1969, pp. 67-73.

Medical Letter, "Prevention and Treatment of Nerve Gas Poisoning," Medical Letter, 32(831), 1990, pp. 103-104.

Medical Letter, "Treatment of Nerve Gas Poisoning," Medical Letter, 37(948), 1995, pp. 43-44.

Meggs, W., and C. Cleveland, "Rhinolaryngoscopic Examination of Patients with the Multiple Chemical Sensitivity Syndrome," Arch Environ Health, 48(1), 1993, pp. 14-18.

Melnick, J. L., E. Adam, et al., "Cytomegalovirus and Atherosclerosis," Eur Heart J, 14, 1993, Supplement K, pp. 30-38.

Melnick, S. L., E. Shahar, et al., "Past Infection by Chlamydia Pneumoniae Strain TWAR and Asymptomatic Carotid Atherosclerosis. Atherosclerosis Risk in Communities (ARIC) Study Investigators," Am J Med, 95(5), 1993, pp. 499-504.

Meltzer, H. Y., R. C. Arora, et al., "Serotonin Uptake in Blood Platelets of Psychiatric Patients," Archives of General Psychiatry, 38(12), 1981, pp. 1322-1326.

Merrill, J., and J. Weller, "Treatment of Bromism with the Artificial Kidney," Ann Intern Med, 37, 1952, pp. 186-190.

Meshul, C., A. Boyne, et al., "Comparison of the Ultrastructural Myopathy Induced by Anticholinesterase Agents at the End Plates of Rat Soleus and Extensor Muscles," Experimental Neurology, 89(1), 1985, pp. 96-114.

Metcalf, D., and J. Holmes, "EEG, Psychological and Neurological Alterations in Humans with Organophosphorus Exposure," Ann NY Acad Sci, 160, 1969, pp. 359-365.

Metcalf, J., statement made by Rep. Jack Metcalf (R-Wash.) to the Subcommittee on Human Resources, Government Reform Committee, 1997.

Miczek, K., and P. Donat, "Brain 5-HT Systems and Inhibition of Aggressive Behavior," in T. Archer, P. Bevan, and A. Cools, eds., Behavioral Pharmacology of 5-HT, Hillsdale, N.J.: Lawrence Erlbaum Associates, 1989.

Miczek, K., J. Mos, et al., "Brain 5-HT and Inhibition of Aggressive Behavior in Animals: 5-HIAA and Receptor Subtypes," Psychopharmacol Bull, 25, 1989, pp. 399-403.

Midtling, J. E., P. G. Barnett, et al., "Clinical Management of Field Worker Organophosphate Poisoning," Western J Med, 142(4), 1985, pp. 514-518.

Milatovic, D., and W.-D. Dettbarn, "Modification of Acetylcholinesterase During Adaptation to Chronic, Subacute Paraoxon Application in Rat," Toxicol Appl Pharmacol, 136, 1996, pp. 20-28.

Miller, C., "Possible Models for Multiple Chemical Sensitivity: Conceptual Issues and Role of the Limbic System," Toxicol Ind Health, 8(4), 1992, pp. 181-202.

Miller, C., "White Paper: Chemical Sensitivity: History and Phenomenology," Toxicol Ind Health, 10(4/5), 1994, pp. 253-276.

Miller, C., "Chemical Sensitivity: Symptom, Syndrome, or Mechanism for Disease?" Toxicology, 111, 1996a, pp. 69-86.

Miller, C., invited testimony, Committee on Government Reform and Oversight, Subcommittee on Human Resources and Intergovernmental Relations, U.S. House of Representatives, 1996b.

Miller, C., invited presentation, Presidential Advisory Committee on Gulf War Veterans' Illnesses, 1996c.

Miller, C., "Toxicant-Induced Loss of Tolerance--An Emerging Theory of Disease?" Environmental Health Perspectives, 105, 1997, Supplement 2, pp. 445-453.

Miller, C., and H. Mitzel, "Chemical Sensitivity Attributed to Pesticide Exposure Versus Remodelling," Archives of Environmental Health, 50(2), 1995, pp. 119-129.

Miller, C., N. Ashford, et al., "Empirical Approaches for the Investigation of Toxicant-Induced Loss of Tolerance," Environmental Health Perspectives, 105, 1997, Supplement 2, pp. 515-519.

Miller, R., L. Van Nyhuis, et al., "Comparative Times to Peak Effect and Durations of Action of Neostigmine and Pyridostigmine," Anesthesiology, 41, 1974, pp. 27-33.

Milner, I. B., B. N. Axelrod, et al., "Is There a Gulf War Syndrome?" JAMA, 271(9), 1994, p. 661.

Mirakhur, R., "Spontaneous Recovery or Evoked Reversal of Neuromuscular Block," Acta Anaesthesiol Scand, 39, 1995, Supplement 106, pp. 62-63.

Misra, U., M. Prasad, et al., "A Study of Cognitive Functions and Event Related Potentials Following Organophosphate Exposure," Electromyogr Clin Neurophysiol, 34, 1994, pp. 197-203.

MMWR, "Neurological Findings Among Workers Exposed to Fenthion in a Veterinary Hospital--Georgia," MMWR, 34, 1985, pp. 402-403.

Modrow, H., and J. McDonough, "Effects of Soman and Pyridostigmine on Variable Interval Responding," Neurobehav Toxicol Teratol, 7, 1985, pp. 528-529.

Mohs, R., B. Davis, et al., "Cognitive Effects of Physostigmine and Choline Chloride in Normal Subjects," in K. Davis and P. Berger, eds., Brain Acetylcholine and Neuropsychiatric Disease, New York: Plenum Press, 1979, pp. 237-251.

Mohs, R., B. Davis, et al., "Oral Physostigmine Treatment of Patients with Alzheimer's Disease," Am J Psychiatry, 142, 1985, pp. 28-33.

Monroe, R., "Episodic Behavioral Disorders and Limbic Ictus," in B. Doane and K. Livingston, eds., The Limbic System: Functional Organization and Clinical Disorders, New York: Raven Press, Ltd., 1986, pp. 251-266.

Moretto, A., M. Bertolazzi, et al., "Phenylmethanesulfonyl Fluoride Elicits and Intensifies the Clinical Expression of Neuropathic Insults," Arch Toxicol 66(1), 1992, pp. 67-72.

Moretto, A., M. Bertolazzi, et al., "The Phosphorothioic Acid O-(2-chloro-2,3,3-trifluorocyclobutyl) O-Ethyl S-Propyl Ester Exacerbates Organophosphate Polyneuropathy Without Inhibition of Neuropathy Target Esterase," Toxicol Appl Pharmacol, 129(1), 1994, pp. 133-137.

Moretto, A., and M. Lotti, "Promotion of Peripheral Axonopathies by Certain Esterase Inhibitors," Toxicol Ind Health, 9(6), 1993, pp. 1037-1046.

Moretto, A., and M. Lotti, "Poisoning by Organophosphorus Insecticides and Sensory Neuropathy," J Neurol Neurosurg Psychiatry, 64(4), 1998, pp. 463-468.

Morgan, J., and E. Weaver, "Chronic Bromism Simulating Neurological Diseases," Virginia Medical Monthly, 96, 1969, pp. 262-264.

Moriearty, P., and R. Becker, "Inhibition of Human Brain and RBC Acetylcholinesterase (AChE) by Heptylphysostigmine (HPTL)," Metho Find Exp Clin Pharmacol, 14(8), 1992, pp. 615-621.

Morse, J., and J. Davis, "Regulation of Ischemic Hippocampal Damage in the Gerbil: Adrenalectomy Alters the Rate of CA1 Cell Disappearance," Exp Neurol, 110, 1990, p. 86.

Moser, V., "Comparisons of the Acute Effects of Cholinesterase Inhibitors Using a Neurobehavioral Screening Battery in Rats," Toxicologist, 14, 1994, p. 241.

Moss, J., "Synergism of Toxicity of N,N-Diethyl-m-Toluamide to German Cockroaches (Orthoptera: Blattellidae) by Hydrolytic Enzyme Inhibitors," J Econ Entomol, 89(5), 1996, pp. 1151-1155.

Mota, A., A. Bento, et al., "Role of the Serotonin Receptor Subtype 5-HT1D on Basal and Stimulated Growth Hormone Secretion," J Clin Endocrinol and Metabol, 80(6), 1995, pp. 1973-1977.

Moya-Quiles, M., E. Munoz-Delgado, et al., "Effect of Pyrethroid Insecticide Allethrin on Membrane Fluidity," Biochemistry and Molecular Biology International, 36(6), 1995, pp. 1299-1308.

Moylan-Jones, R., "A Trial of Pyridostigmine Pretreatment for Nerve Agent Poisoning in Man," Chemical Defence Establishment, Technical Note 217, Porton Down, U.K., 1975.

Moylan-Jones, R., D. Parkes, et al., "The Pharmacokinetics of Pyridostigmine in Humans. Part II. Multiple Dose Studies," Chemical Defence Establishment, Technical Paper 258, Porton Down, U.K., 1979.

Moylan-Jones, R., D. Parkes, et al., "Selected Clinical Biochemical Observations in Men Taking Pyridostigmine," Chemical Defence Establishment, Technical Note 476, Porton Down, U.K., August 1981.

Moylan-Jones, R., D. Parkes, et al., "The Effect of Standard Field ("Compo") Rations on the Absorption of Pyridostigmine from the Tablets NAPS L1A1 (U)," Chemical Defence Establishment, Porton Down, U.K., 1984.

Muhlestein, J. B., E. H. Hammond, et al., "Increased Incidence of Chlamydia Species Within the Coronary Arteries of Patients with Symptomatic Atherosclerotic Versus Other Forms of Cardiovascular Disease," J Am Coll Cardiol, 27(7), 1996, pp. 1555-1561.

Mukhopadhyay, S., and M. Poddar, "Caffeine-Induced Locomotor Activity: Possible Involvement of GABAergic-Dopaminergic-Adenosinergic Interaction," Neurochemical Research, 20(1), 1995, pp. 39-44.

Muldoon, M., E. Bachen, et al., "Acute Cholesterol Responses to Mental Stress and Change in Posture," Arch Intern Med, 152, 1992, pp. 775-780.

Mumford, S., Memorandum 30, Serial No. 33, Chemical Defence Establishment, Porton Down, U.K., 1950.

Murialdo, G., S. Fonzi, et al., "Effects of Pyridostigmine, Corticotropin-Releasing Hormone and Growth Hormone-Releasing Hormone on the Pituitary-Adrenal Axis and on Growth Hormone Secretion in Dementia," Neuropsychobiology, 28, 1993, pp. 177-183.

Murphy, F., H. Kang, et al., "Executive Summary: Cooperative Study #458, National Health Survey of Persian Gulf Veterans and Their Families," VA Cooperative Studies Program, 1998.

Murphy, M., D. Blick, et al., Physiological and Performance Effects of Pyridostigmine Bromide in Rats and Monkeys, Fifth Annual Chemical Defense and Bioscientific Review Abstract, Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, 1985.

Murphy, M., D. Blick, et al., "Effects of Diazepam on Soman-Induced Lethality, Convulsions, and Performance Deficit," Systems Research Laboratories, a division of Arvin/Calspan, with Texas A&M Research Foundation, 1989.

Murphy, M., D. Blick, et al., "Diazepam as a Treatment for Nerve Agent Poisoning in Primates," Aviat Space Environ Med, 64, 1993, pp. 110-115.

Murphy, R., and F. Zemlan, "Differential Effects of Substance P on Serotonin-Modulated Spinal Nociceptive Reflexes," Psychopharmacology (Berlin), 93, 1987, pp. 118-121.

Murray, C., and H. Fibiger, "Learning and Memory Deficits After Lesions of the Nucleus Basalis Magnocellularis: Reversal by Physostigmine," Neuroscience, 14, 1985, pp. 1025-1032.

Mutch, E., P. Blain, et al., "Interindividual Variations in Enzymes Controlling Organophosphate Toxicity in Man," Human and Experimental Toxicology, 11, 1992, pp. 109-116.

Nagayama, M., F. Akahori, et al., "Effects of Selected Organophosphate Insecticides on Serum Cholinesterase Isoenzyme Patterns in the Rat," Vet Human Toxicol, 38(3), 1996, pp. 196-199.

Narahashi, T., "Nerve Membrane Ionic Channels as the Primary Target of Pyrethroid," Neurotoxicol, 6, 1985, pp. 3-22.

Natelson, B., J. Ottenweller, et al., "Persisting Effects of Oral Pyridostigmine Bromide on the Behavior of Rats," Society for Neuroscience, 22, 1996, p. 95.3.

National Institutes of Health, "The Persian Gulf Experience and Health," 1994.

Nelson, J. D., N. L. Adams, "Intensive Care of the Soman Intoxicated Primate," The Pharmacologist, 24, 1982, p. 220.

"Nerve Agents: GA GB GD GF VX,", accessed 1997.

Nethercott, J., L. Davidoff, et al., "Multiple Chemical Sensitivities Syndrome: Toward a Working Case Definition," Archives of Environmental Health, 48(1), 1993, pp. 19-26.

Newmark, J., and W. Clayton, "Persian Gulf Illnesses: Preliminary Neurological Impressions," Military Medicine, 160, pp. 505-507.

Nicolson, G. L., and N. L. Nicolson, "Chronic Fatigue Illness and Operation Desert Storm," J Occup Environ Med, 38, 1995, pp. 14-16.

Nicolson, G. L., and N. L. Nicolson, "The Eight Myths of Operation `Desert Storm' and Gulf War Syndrome," Med Conflict and Survival, 13, 1997, pp. 140-146.

Nieto, F. J., E. Adam, et al., "Cohort Study of Cytomegalovirus Infection as a Risk Factor for Carotid Intimal-Medial Thickening, a Measure of Subclinical Atherosclerosis," Circulation, 94(5), 1996, pp. 922-927.

Nilsson, A., "Connection Between Smoking and Reduced Risk of Ulcerative Colitis. Does Nicotine Mediate a Protective Effect?" Lakartidningen, 92(50), 1995, pp. 4788-4792.

Nilsson-Haransson, L., Z. Lai, et al., "Tetrahydroaminoacridine Induces Opposite Changes in Muscarinic and Nicotinic Receptors in the Rat Brain," Eur J Pharmacol, 186, 1990, pp. 301-305.

Noble, D., "Back into the Storm: Reanalyzing Health Effects of the Gulf War," Analytic Chemistry, 66(15), 1994, pp. 805-808.

"Nonpsychotropic Drugs May Cause Sleep Disturbances," Drugs and Therapy Perspectives, 10(12), 1997, pp. 10-13.

Nordberg, A., G. Wahlstrom, et al., "Effect of Long-Term Nicotine Treatment on [3H]nicotine Binding Sites in the Rat's Brain," Drug and Alcohol Dependence, 16, 1985, pp. 9-17.

Nordgren, I., B. Karlen, et al., "Intoxications with Anticholinesterases: Effect of Different Combinations of Antidotes on the Dynamics of Acetylcholine in Mouse Brain," Pharmacology and Toxicology, 70, 1992, pp. 384-388.

Nose, T., and H. Takemoto, "Effect of Oxotremorine on Homovanillic Acid Concentration in Striatum of Rat," Eur J Pharmacol, 25, 1974, p. 51.

Obermeyer, W. H., and R. M. Benca, "Effects of Drugs on Sleep," Neurol Clin, 14(4), 1996, pp. 827-840.

Office of the Special Assistant to the Secretary of Defense for Gulf War Illnesses (OSAGWI), "Case Narrative: Khamisiyah," Washington, D.C., 1997.

Ohara, M., M. Hirohata, et al., "Family of a Patient with Serum Cholinesterase Deficiency," Internal Medicine, 31(3), 1992, pp. 397-399.

Ohno, M., M. Kobayashi, et al., "Working Memory Failure by Combined Blockade of Muscarinic and Beta-Adrenergic Transmission in the Rat Hippocampus," Neuroreport, 8(7), 1997, pp. 1571-1575.

Ohtawa, M., M. Seko, et al., "Effects of Aluminium Ingestion on Lipid Peroxidation in Rats," Chem Pharm Bull, 31, 1983, pp. 1415-1418.

O'Keane, V., K. Abel, et al., "Growth Hormone Responses to Pyridostigmine in Schizophrenia: Evidence for Cholinergic Dysfunction," Biol Psychiatry, 36, 1994, pp. 582-588.

O'Keane, V., and T. Dinan, "Sex Steroid Priming Effects on Growth Hormone Response to Pyridostigmine Throughout the Menstrual Cycle," J Clin Endocrinology and Metabolism, 75(1), 1992, pp. 11-14.

O'Keane, V., K. O'Flynn, et al., "Pyridostigmine-Induced Growth Hormone Responses in Healthy and Depressed Subjects: Evidence for Cholinergic Supersensitivity in Depression," Psychological Medicine, 22, 1992, pp. 55-60.

Okhawa, H., H. Oshita, et al., "Comparison of Inhibitory Activity of Various Organophosphorus Compounds Against Acetylcholinesterase and Neurotoxic Esterase of Hens with Respect to Delayed Neurotoxicity," Biochem Pharmacol, 29, 1980, pp. 2721-2727.

Olivier, B., J. Mos, et al., "Modulatory Action of Serotonin in Aggressive Behaviour," in T. Archer, P. Bevan, and A. Cools, eds., Behavioral Pharmacology of 5-HT, Hillsdale, N.J.: Lawrence Erlbaum Associates, 1989.

O'Neill, J., "Non-Cholinesterase Effects of Anticholinesterases," Fundam Appl Toxicol, 1, 1981, pp. 154-160.

Ortiz, D., L. Yanez, et al., "Acute Toxicological Effects in Rats Treated with a Mixture of Commercially Formulated Products Containing Methyl Parathion and Permethrin," Ecotoxicol Environ Saf, 32(2), 1995, pp. 154-158.

Osame, M., M. Kawabuchi, et al., "Experimental Nemaline Rods Induced by Anticholinesterase Drug (Neostigmine Methylsulfate)," Proc Jpn Acad, 51, 1975, pp. 598-603.

Osimitz, T. G., and R. H. Grothaus, "The Present Safety Assessment of DEET," J Am Mosq Control Assoc, 11(2 Pt 2), 1995, pp. 274-278.

Osimitz, T. G., and J. V. Murphy, "Neurological Effects Associated with Use of the Insect Repellent N,N-Diethyl-m-Toluamide (DEET)," J Toxicol Clin Toxicol, 35(5), 1997, pp. 435-441.

Ottenweller, J., personal communication, 1998.

Overstreet, D., L. Dilsaver, et al., "Effects of Light on Responsiveness to a Muscarinic Agonist in Rats Selectively Bred for Endogenously Increased Cholinergic Function," Psychiatry Res, 33, 1990, pp. 139-150.

Overstreet, D., D. Janowsky, et al., "Enhanced Elevation of Corticosterone Following Arecoline Administration to Rats Selectively Bred for Increased Cholinergic Function," Psychopharmacology (Berl), 88, 1986a, pp. 129-130.

Overstreet, D., D. Janowsky, et al., "Stress-Induced Immobility in Rats with Cholinergic Supersensitivity," Biol Psychiatry, 21, 1986b, pp. 657-664.

Overstreet, D., D. Janowsky, et al., "Alcoholism and Depressive Disorders: Is Cholinergic Sensitivity a Biological Marker?" Alcohol Alcohol, 24, 1989, pp. 253-255.

Overstreet, D., D. Janowsky, et al., "Swim Test Immobility Co-Segregates with Serotonergic but Not Cholinergic Sensitivity in Cross-Breeds of Flinders Line Rats," Psychiatr Genet, 4, 1994, pp. 101-107.

Overstreet, D., A. Rezvani, et al., "Impaired Active Avoidance Responding in Rats Selectively Bred for Increased Cholinergic Function," Physiol Behav, 47, 1990, pp. 787-788.

Overstreet, D., A. Rezvani, et al., "Genetic Animal Models of Depression and Ethanol Preference Provide Support for Cholinergic and Serotonergic Involvement in Depression and Alcoholism," Biol Psychiatry, 31, 1992, pp. 919-936.

Overstreet, D., R. Russell, et al., "Genetic and Pharmacological Models of Cholinergic Supersensitivity and Affective Disorders," Experientia, 44, 1988, pp. 465-472.

Owens, M., D. Overstreet, et al., "Alterations in the Hypothalamic Pituitary-Adrenal Axis in a Proposed Animal Model of Depression with Genetic Muscarinic Susceptibility," Neuropsychopharmacology, 4, 1991, pp. 87-93.

Padilla, S., "The Neurotoxicology of Cholinesterase-Inhibiting Insecticides: Past and Present Evidence Demonstrating Persistent Effects," Inhalation Toxicology, 7, 1995, pp. 903-907.

Pappata, S., B. Tavitian, et al., "In Vivo Imaging of Human Cerebral Acetylcholinesterase," J Neurochem, 67(2), 1996, pp. 876-879.

Park, K., D. Kim, et al., "Pyridostigmine Toxicity: Electrophysiological Study," Electromyogr Clin Neurophysiol, 33, 1993, pp. 323-328.

Parker, F., J. Barber, et al., "Laboratory Techniques for Determining the Effects of Pyridostigmine Bromide," USAF School of Aerospace Medicine, Brooks AFB, Tex., 1986.

Parker, F., J. Barber, et al., "Chemical Defense Pretreatment Drugs in the Aerospace Environment: An Overview of Biochemical Analyses from Pyridostigmine Bromide Studies Conducted for the USAF School of Aerospace Medicine," USAF School of Aerospace Medicine, Brooks AFB, Tex., 1989.

Pascuzzo, G., A. Akaike, et al., "The Nature of the Interactions of Pyridostigmine with the Nicotinic Acetylcholine Receptor-Ionic Channel Complex I. Agonist, Desensitizing, and Binding Properties," Mol Pharmacol, 25, 1984, pp. 92-101.

Patrick, J., personal communication, 1997.

Patrick, J., P. Sequela, et al., "Functional Diversity of Neuronal Nicotinic Acetylcholine Receptors," in A. Cuello, ed., Progress in Brain Research, 98, 1993, pp. 113-120.

Patterson, S., J. Gottdiener, et al., "Effects of Acute Mental Stress on Serum Lipids: Mediating Effects of Plasma Volume," Psychosomatic Med, 55, 1993, pp. 525-532.

Pauly, J., M. Marks, et al., "An Autoradiographic Analysis of Cholinergic Receptors in Mouse Brain After Chronic Nicotinic Treatment," J Pharmacol Exp Therapeutics, 258(3), 1991, pp. 1127-1136.

PB1 Internet Site, "Nerve Agents: GA GB GD GF VX," accessed 1997.

Peacock, M., M. Morris, et al., "Sleep Apnea-Hypopnea Syndrome in a Sample of Veterans of the Persian Gulf War," Military Medicine, 162(4), 1997, pp. 249-251.

Pelckmans, M., W. Verdickt, et al., "Bromism: Rare But Still Present," Acta Clinica Belgica, 38(6), 1983, pp. 397-400.

Pelligrini, G., and R. Santi, "Potentiation of Toxicity of Organophosphorus Compounds Containing Carboxylic Acid Functions Towards Warm-Blooded Animals by Some Organophosphorus Impurities," J Agric Food Chem, 20, 1972, pp. 944-950.

Penman, A., R. Tarver, et al., "No Evidence of Increase in Birth Defects and Health Problems Among Children Born to Persian Gulf War Veterans in Mississippi," Milit Med, 161, 1996, pp. 1-6.

Pennisi, E., "Chemicals Behind Gulf War Syndrome?" Science, 272, 1996, pp. 479-480.

Perrotta, D., "Long-Term Health Effects Associated with Sub-Clinical Exposures to GB and Mustard," Environmental Committee Armed Forces Epidemiological Board, 1996.

Persian Gulf Veterans Coordinating Board, "Unexplained Illnesses Among Desert Storm Veterans," Arch of Intern Med, 155, 1995, pp. 262-268.

Persian Gulf War (PGW) Illnesses Task Force, "Khamisiyah: A Historical Perspective on Related Intelligence," 1997, pp. 1-24.

Peters, B., and H. Levin, "Memory Enhancement After Physostigmine in the Amnesic Syndrome," Arch Neurol, 34, 1977, p. 215.

Petersdorf, R., W. Page, et al., eds., Interactions of Drugs, Biologics, and Chemicals in US Military Forces (Institute of Medicine), Washington, D.C.: National Academy Press, 1996.

Peterson, R., "Scopolamine Induced Learning Failures in Man," Psychopharmacology, 52, 1977, p. 283.

Petrali, J., A Study of the Effect of Soman on the Rat Blood-Brain Barrier, 4th Annual Chemical Defense Bioscience Review, Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, 1984.

Phillips, L. H., and J. C. Torner, "Epidemiologic Evidence for a Changing Natural History of Myasthenia Gravis," Neurology, 47(5), 1996, pp. 1233-1238.

Picciotto, M., M. Zoli, et al., "Acetylcholine Receptors Containing the §2 Subunit Are Involved in the Reinforcing Properties of Nicotine," Nature, 391, 1998, pp. 173-177.

Piesner, A., P. Arlien-Soborg, et al., "Neurological Complications and Japanese Encephalitis Vaccination," Lancet, 348, 1996, pp. 202-203.

Ploeckinger, B., K. Dantendorfer, et al., "Rapid Decrease of Serum Cholesterol and Postpartum Depression," BMJ, 313, 1996, pp. 664-679.

Pollay, M., "The Processes Affecting the Distribution of Bromide in Blood, Brain, and CSF," Exp Neurol, 17, 1967, pp. 74-85.

Pool, W., and D. Hane, "Acute Toxicity of Pyridostigmine Bromide (Mestinon) in Adult and Neonatal Rats," Nutley, N.J., Roche Laboratories (internal report), 1972.

Pope, C., "Pyridostigmine, Organophosphates and Gulf War Illnesses: Background Material and Preliminary Assessments," prepared for Investigation and Analysis Directorate, OSAGWI, 1997.

Pope, C., T. Chakraborti, et al., "Long-Term Neurochemical and Behavioral Effects Induced by Acute Chlorpyrifos Treatment," Pharmacol Biochem Behav, 42, 1992, pp. 251-256.

Pope, C. N., and S. Padilla, "Promotion of Organophosphate-Induced Delayed Polyneuropathy by Phenylmethanesulfonyl Fluoride," Toxicol Appl Pharmacol, 110(1), 1991, pp. 179-180.

Pope, C. N., D. Tanaka, Jr., and S. Padilla, "The Role of Neurotoxic Esterase (NTE) in the Prevention and Potentiation of Organophosphorous-Induced Delayed Neurotoxicity," Chemico-Biological Interactions, 87(1-3), 1993, pp. 395-406.

Prendergast, M., statement by Deputy Commissioner and Senior Advisor to the Commissioner, Food and Drug Administration, Department of Health and Human Services, before the Presidential Advisory Committee on Gulf War Veterans' Illnesses, 1997.

Preston, K., and C. Schuster, "Conditioned Gustatory Avoidance Induced by Cholinergic Agents," Pharmacol Biochem Behav, 15, 1981, pp. 827-828.

Preusser, H.-J., "Die Ultrastruktur der motorischen Endplatte im Zwerchfell der Ratte und Veranderungen nach Inhibierung der Acetylcholinesterase," Zellforsch, 80, 1967, pp. 436-457.

Prioux-Guyonneau, M., C. Coudray-Lucas, et al., "Modification of Rat Brain 5-Hydroxytryptamine Metabolism by Sublethal Doses of Organophosphate Agents," Acta Pharmacologica et Toxicologica, 51(4), 1982, pp. 278-284.

Procopio, M., C. Invitti, et al., "Effect of Arginine and Pyridostigmine on the GHRH-Induced GH Rise in Obesity and Cushing's Syndrome," International J of Obesity, 19, 1995, pp. 108-112.

Prusaczyk, W., and M. Sawka, "Effects of Pyridostigmine Bromide on Human Thermoregulation During Cold Water Immersion," J Appl Physiol, 71, 1991, pp. 432-437.

Pscheidt, G. R., Z. Votava, and H. E. Himwich, "Effect of Physostigmine on the Level of Brain Biogenic Amines in Rats and Rabbits," Biochem Pharmacol, 16(6), 1967, pp. 1132-1134.

Pucilowski, O., B. Eichelman, et al., "Enhanced Affective Aggression in Genetically Bred Hypercholinergic Rats," Neuropsychobiology, 24, 1990, pp. 37-41.

Pullan, R. D., "Colonic Mucus, Smoking and Ulcerative Colitis," Ann R Coll Surg Engl, 78(2), 1996, pp. 85-91.

Pullan, R. D., J. Rhodes, et al., "Transdermal Nicotine for Active Ulcerative Colitis," New Engl J Med, 330(12), 1994, pp. 811-815.

Puolakkainen, M., C. C. Kuo, et al., "Serological Response to Chlamydia Pneumoniae in Adults with Coronary Arterial Fatty Streaks and Fibrolipid Plaques," J Clin Microbiol, 31(8), 1993, pp. 2212-2214.

Puttfarcken, P. S., A. M. Manelli, et al., "Evidence for Nicotinic Receptors Potentially Modulating Nociceptive Transmission at the Level of the Primary Sensory Neuron: Studies with F11 Cells," J Neurochem, 69(3), 1997, pp. 930-938.

Pyridostigmine Bromide New Drug Application (pending), filed May 1996.

Radcliffe, M., P. Ashurst, et al., "Unexplained Illness: The Mind Versus the Environment," J Royal Society of Medicine, 88, 1995, pp. 678-679.

Ram, Z., M. Molcho, et al., "The Effect of Pyridostigmine on Respiratory Function in Healthy and Asthmatic Volunteers," Isr J Med Sci, 27, 1991, pp. 664-668.

Rama, D., "Biological Monitoring for Organophosphate/Carbamate Pesticides--the Cholinesterase Assay," SAMJ, 84, 1994, pp. 298-299.

Rao, T. S., L. D. Correa, et al., "Evaluation of Anti-Nociceptive Effects of Neuronal Nicotinic Acetylcholine Receptor (NAChR) Ligands in the Rat Tail-Flick Assay," Neuropharmacology, 35(4), 1996, pp. 393-405.

Rapaport, M., S. C. Risch, et al., "The Effects of Physostigmine Infusion on Patients with Panic Disorder," Biol Psychiatry, 29(7), 1991, pp. 658-664.

Rapoport, S., Blood-Brain Barrier in Physiology and Medicine, New York: Raven Press, 1976.

Raskind, M., E. Peskind, et al., "Neuroendocrine Response to Physostigmine in Alzheimer's Disease," 46, 1989, pp. 535-540.

Rausch, J. L., D. S. Janowsky, et al., Physostigmine Effects on Serotonin Uptake in Human Blood Platelets," Eur J Pharmacol, 109(1), 1985, pp. 91-96.

Rausch, J. L., N. S. Shah, et al., "Platelet Serotonin Uptake in Depressed Patients: Circadian Effect," Biol Psychiatry, 17(1), 1982, pp. 121-123.

Ray, S., and M. Poddar, "Central Cholinergic-Dopaminergic Interaction in Carbaryl-Induced Tremor," Eur J Pharmacol, 119, 1986, pp. 251-253.

Redhead, K., G. Quinlan, et al., "Aluminium-Adjuvanted Vaccines Transiently Increase Aluminium Levels in Murine Brain Tissue," Pharmacology and Toxicology, 70, 1992, pp. 278-280.

Rest, K., "Advancing the Understanding of Multiple Chemical Sensitivity (MCS): Overview and Recommendations from an AOEC Workshop," Toxicol Ind Health, 8, 1992, pp. 1-13.

Rettig, R. A., Military Use of Drugs Not Approved by the FDA for CW/BW Defense: Lessons from the Gulf War, Santa Monica, Calif.: RAND, MR-1018/9, 1999.

Revell, T., "The Gulf War Syndrome" (letter) (see comments), BMJ (Clinical Research Edition), 310(6986), 1995, p. 1073.

Rhodes, J., and G. Thomas, "Nicotine Treatment in Ulcerative Colitis. Current Status," Drugs, 49(2), 1995, pp. 157-160.

Richelson, E., "Desensitization of Muscarinic Receptor-Mediated Cyclic GMP Formation by Cultured Nerve Cells," Nature (London), 272, 1978, pp. 366-368.

Richter, E., P. Chuwers, et al., "Health Effects from Exposure to Organophosphate Pesticides in Workers and Residents in Israel," Isr J Med Sci, 28, 1992, pp. 584-597.

Rider, J., L. Ellinwood, et al., "Production of Tolerance in the Rat to Octamethyl Pyriophosphormaide (OMPA)," Proc Soc Exp Biol Med, 81, 1952, pp. 455-459.

Risch, S. C., P. Cohen, et al., "Physostigmine Induction of Depressive Symptomatology in Normal Human Subjects," Psychiatry Res, 4, 1981, pp. 89-94.

Risch, S. C., D. Janowsky, et al., "Muscarinic Supersensitivity of Anterior Pituitary ACTH and Beta Endorphin Release in Major Depressive Illness," Peptides, 9, 1981, pp. 789-792.

Risch, S. C., D. Janowsky, et al., "Cholinomimetic-Induced Co-Release of Prolactin and Beta-Endorphin in Man," Psychopharmacol Bull, 18, 1982a, pp. 21-25.

Risch, S. C., D. Janowsky, et al., "Correlated Cholinomimetic-Stimulated Beta-Endorphin and Prolactin Release in Humans," Peptides, 3, 1982b, pp. 319-322.

Risch, S. C., N. Kalin, et al., "Cholinergic Challenges in Affective Illness: Behavioral and Neuroendocrine Correlates," J Clin Psychopharmacol, 1, 1981, pp. 186-192.

Risch, S. C., N. Kalin, et al., "Co-Release of ACTH and Beta-Endorphin Immunoreactivity in Human Subjects in Response to Central Cholinergic Stimulation," Science, 222, 1983, p. 77.

Roach, J., A. Eliasson, et al., "The Effect of Pyridostigmine on Bronchial Hyperreactivity," Army ACP Meeting, abstract, 1991, p. 451.

Robbins, T. W., G. McAlonan, et al., "Cognitive Enhancers in Theory and Practice: Studies of the Cholinergic Hypothesis of Cognitive Deficits in Alzheimer's Disease," Behav Brain Res, 83(1-2), 1997, pp. 15-23.

Roberts, D., "EMG Voltage and Motor Nerve Conduction Velocity in Organophosphorus Pesticide Factory Workers," Int Arch Occup Environ Hlth, 1974, pp. 267-274.

Roberts, D., and S. Thesleff, "Acetylcholine Release from Motor-Nerve Endings in Rats Treated with Neostigmine," Eur J Pharmacol, 6, 1969, pp. 281-285.

Roberts, D. E., M. N. Sawka, et al., "Pyridostigmine Bromide Does Not Alter Thermoregulation During Exercise in Cold Air," Can J Physiol Pharmacol, 72, 1994, pp. 788-793.

Robinson, D., and R. McGee, "Agonist-Induced Regulation of Neuronal Nicotinic Acetylcholine Receptor of PC12 Cells," Mol Pharmacol, 27, 1985, pp. 409-417.

Robinson, T., and J. Becker, "Enduring Changes in Brain and Behavior Produced by Chronic Amphetamine Administration: A Review and Evaluation of Animal Models of Amphetamine Psychosis," Brain Res Rev, 11, 1986, pp. 157-198.

Robinson, T., J. Becker, et al., "Long-Term Facilitation of Amphetamine-Induced Rotational Behavior and Striatal Dopamine Release Produced by a Single Exposure to Amphetamine: Sex Differences," Brain Res. 253, 1982, pp. 231-241.

Rockefeller Report, "Investigational Drugs Used in the Persian Gulf War," 1997.

Rodnitzky, R., H. Levin, et al., "Occupational Exposure to Organophosphate Pesticides: Neurobehavioral Study," Arch Environ Health, 30, 1975, pp. 98-103.

Roland, E., J. Jan, et al., "Toxic Encephalopathy in a Child After Brief Exposure to Insect Repellents," Can Med Assoc J, 132, 1985, pp. 155-156.

Role, L., and D. Berg, "Nicotinic Receptors in the Development and Modulation of CNS Synapses," Neuron, 16(6), 1996, pp. 1077-1085.

Romano, J., and J. King, "Conditioned Taste Aversion and Cholinergic Drugs: Pharmacological Antagonism," Pharmacology Biochemistry and Behavior, 27, 1987, pp. 81-85.

Romano, J., and M. Landauer, "Effects of the Organophosphorus Compound, O-Ethyl-N-Dimethyl-Phosphoramidocyanidate (Tabun) on Flavor Aversions, Locomotor Activity, and Rotarod Performance in Rats," Fundam Appl Toxicol, 6, 1986, pp. 62-68.

Romano, J., J. King, et al., "A Comparison of Physostigmine and Soman Using Taste Aversion and Nociception," Neurobehav Toxicol Teratol, 7, 1985, pp. 243-249.

Rose, G., and A. Dewar, "Intoxication with Four Synthetic Pyrethroids Fails to Show Any Correlation Between Neuromuscular Dysfunction and Neurochemical Abnormalities in Rats," Arch Toxicol, 53, 1983, pp. 297-316.

Rosenstock, H. A., "Sertraline Withdrawal in Two Brothers: A Case Report," International Clin Psychopharmacology, 11(1), 1996, pp. 58-59.

Rosenstock, L., M. Keifer, et al., "Chronic Central Nervous System Effects of Acute Organophosphate Pesticide Intoxication," Lancet, 338, 1991, pp. 223-227.

Roskams, A., and J. Connor, "Aluminium Access to the Brain: A Role for Transferring and Its Receptor," Proc Natl Acad Sci, 87, 1990, pp. 9024-9027.

Rostker, Bernard, letter to Gulf War veterans, July 24, 1997,, (

Rothenberg, D., A. Berns, et al., "Bromide Intoxication with Carbromal Preparations," J Toxicol Clin Toxicol, 23, 1990, pp. 341-346.

Rothrock, J., "Making Sense of the New Migraine Drugs," UCSD Department of Medicine, Grand Rounds, La Jolla, Calif., January 12, 1999.

Rotman, A., "Blood Platelets in Psychopharmacological Research," Progress in Neuro-Psychopharmacol and Biol Psychiatry, 7(2-3), 1983, pp. 135-151.

Roy, M., P. Koslowe, et al., "Signs, Symptoms and Ill-Defined Conditions in Persian Gulf War Veterans: Findings from the Comprehensive Clinical Evaluation Program," Psychosomatic Medicine, 60, 1998, pp. 663-668.

Rubin, L., and M. Goldberg, "Effect of Sarin on Dark Adaptation in Man: Threshold Changes," J Appl Physiol, II(3), 1957, pp. 439-444.

Rubin, L., and M. Goldberg, "Effect of Sarin on Dark Adaptation in Man: Mechanisms of Action," J Appl Physiol, II(3), 1957, pp. 445-449.

Rupniak, N. M., S. Patel, et al., "Antinociceptive and Toxic Effects of (+)-Epibatidine Oxalate Attributable to Nicotinic Agonist Activity," Br J Pharmacol, 113(4), 1994, pp. 1487-1493.

Russ, C., J. Powell, et al., "K Variant of Butyryl Cholinesterase and Late-Onset Alzheimer's Disease," Lancet, 351, 1998, p. 881.

Russell, R., R. Booth, et al., "Behavioral, Neurochemical and Physiological Effects of Repeated Exposures to Subsymptomatic Levels of the Anticholinesterase, Soman," Neurobehav Toxicol Teratol, 8, 1986, pp. 675-685.

Russell, R. W., R. A. Booth, et al., "Roles of Neurotransmitter Receptors in Behavior: Recovery of Function Following Decreases in Muscarinic Receptor Density Induced by Cholinesterase Inhibition," Behav Neurosci, 103(4), 1989, pp. 881-892.

Russell, R., D. Overstreet, et al., "Experimental Tests of Hypothesis About Neurochemical Mechanisms Underlying Behavioral Tolerance to the Anticholinesterase, Diisopropyl Fluorophosphate," J Pharmacol Exp Therapeutics, 192, 1975, pp. 73-85.

Rustam, H., R. Von Burg, et al., "Evidence for a Neuromuscular Disorder in Methylmercury Poisoning," Arch Environ Health, 30, 1975, pp. 190-195.

Ryan, C., L. Morrow, et al., "Cacosmia and Neurobehavioral Dysfunction Associated with Occupational Exposure to Mixtures of Organic Solvents," Am J Psychiatry, 145(11), 1988, pp. 1442-1445.

Ryder, R., T. Hayes, et al., "How Soon After Myocardial Infarction Should Plasma Lipid Values Be Assessed?" BMJ, 289, 1984, pp. 1651-1653.

Safer, D., and R. Allen, "The Central Effects of Scopolamine in Man," Biol Psychiatry, 3, 1971, p. 347.

Saikku, P., "Chlamydia Pneumoniae and Atherosclerosis--An Update," Scand J Infect Dis Suppl, 104, 1997, pp. 53-56.

Saleh, M., M. Zied, et al., "Gamma Aminobutyric Acid Radioreceptor-Assay: A Possible Biomarker for Human Exposure to Certain Agrochemicals," J Environ Sci Health, B28(6), 1993, pp. 687-699.

Salpeter, M., H. Kasprzak, et al., "Endplates After Esterase Inactivation in Vivo: Correlation Between Esterase Concentration, Functional Response and Fine Structure," J Neurocytol, 8, 1979, pp. 96-115.

Sanchez-Arroyos, R., J. Gaztelu, et al., "Hippocampal and Entorhinal Glucose Metabolism in Relation to Cholinergic Theta Rhythm," Brain Res Bull, 32, 1993, pp. 171-178.

Sandborn, W. J., W. J. Tremaine, et al., "Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis. A Randomized, Double-Blind, Placebo-Controlled Trial," Ann Intern Med, 126(5), 1997, pp. 364-371.

Sandyk, R., and G. I. Awerbuch, "The Co-Occurrence of Multiple Sclerosis and Migraine Headache: the Serotoninergic Link," Int J Neurosci, 76(3-4), 1994, pp. 249-257.

Sangster, B., J. Blom, et al., "The Influence of Sodium Bromide in Man: A Study in Human Volunteers with Special Emphasis on the Endocrine and the Central Nervous System," Food Chem Toxicol, 21, 1983, pp. 409-419.

Santolucito, J. A., and G. Morrison, "EEG of Rhesus Monkeys Following Low-Level Feeding of Pesticides," Toxicol Appl Pharmacol, 19, 1971, pp. 147-154.

Sapolsky, R., Stress, the Aging Brain, and the Mechanisms of Neuronal Death. Cambridge, Mass.: MIT Press, 1992.

Sapolsky, R., and W. Pulsinelli, "Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications," Science, 121, 1985, p. 1605.

Sargin, H., S. Cirak, et al., "A Case of Porphyria Due to Carbaryl Intoxication," Human and Experimental Toxicology, 11, 1992, p. 373.

Sarno, A., "More on Desert Storm (letter)," JAMA, 266(23), 1991, p. 3282.

Sarter, M., and J. P. Bruno, "Cognitive Functions of Cortical Acetylcholine: Toward a Unifying Hypothesis," Brain Res Rev, 23(1-2), 1997, pp. 28-46.

Saskin, P., H. Moldofsy, et al., "Sleep and Posttraumatic Rheumatic Pain Modulation Disorder (Fibrositis Syndrome)," Psychosomatic Medicine, 48(5), 1986, pp. 319-323.

Sastry, B., and C. Sadavongvivad, "Cholinergic Systems in Non-Nervous Tissues," Pharmacological Reviews, 30(1), 1979, pp. 65-132.

Sato, M., R. Racine, et al., "Kindling: Basic Mechanisms and Clinical Validity," Electroencephalogr Clin Neurophysiol, 76, 1990, pp. 459-472.

Savage, E., R. Keefe, et al., "Chronic Neurologic Sequelae of Acute Organophosphate Pesticide Poisoning," Archives of Environmental Health, 43(1), 1988, pp. 38-45.

Sayed, A., "Mania and Bromism," Am J Psychiatry, 133, 1976, p. 228.

Scadding, G., C. Havard, et al., "The Long Term Experience of Thymectomy for Myasthenia Gravis," J Neurol Neurosurg Psychiatry, 48, 1985, pp. 401-406.

Schachter, S., American Epilepsy Society meeting, Boston, Mass., 1997.

Schiller, G., "Reduced Binding of (3H) Quinuclidinyl Benzilate Associated with Chronically Low Acetylcholinesterase Activity," Life Sci, 24, 1979, pp. 1159-1164.

Schmitz, E. B., J. Moriarty, et al., "Psychiatric Profiles and Patterns of Cerebral Blood Flow in Focal Epilepsy: Interactions Between Depression, Obsessionality, and Perfusion Related to the Laterality of the Epilepsy," J Neurol Neurosurg Psychiatry, 62(5), 1997, pp. 458-463.

Schoenig, G. P., R. E. Hartnagel, Jr., et al., "Absorption, Distribution, Metabolism, and Excretion of N,N-Diethyl-M-Toluamide in the Rat," Drug Metab Dispos, 24(2), 1996, pp. 156-163.

Schoenig, G., R. Hartnagel, et al., "Neurotoxicity Evaluation of N, N-Diethyl-m-Toluamide (DEET) in Rats," Fundam Appl Toxicol, 21, 1993, pp. 355-365.

Schon, F., M. Drayson, et al., "Myasthenia Gravis and Elderly People," Age Ageing, 25(1), 1996, pp. 56-58.

Schottenfeld, R. S., "Workers with Multiple Chemical Sensitivities: A Psychiatric Approach to Diagnosis and Treatment," Occup Med: State Art Rev, 2(4), 1987, pp. 739-754.

Schrand, J. R., "Is Sleep Apnea a Predisposing Factor for Tobacco Use?" Med Hypotheses, 47(6), 1996, pp. 443-448.

Schulman, H., "Calcium Dependent Protein Kinases and Neuronal Function," TIPS, 5, 1984, pp. 188-192.

Schuschereba, S., P. Bowman, et al., "Myopathic Alterations in Extraocular Muscle of Rats Subchronically Fed Pyridostigmine Bromide," Toxicologic Pathology, 18(3), 1990, pp. 387-395.

Schwab, B., and S. Murphy, "Induction of Anticholinesterase Tolerance in Rats Using Doses of Disulfoton Which Produce No Cholinergic Signs," J Toxicol Environ Health, 8, 1981, pp. 199-204.

Schwab, B., H. Hand, et al., "Reduced Muscarinic Receptor Biding in Tissues of Rats Tolerant to the Insecticide Disulfoton," Neurotoxicology, 2, 1981, pp. 635-648.

Schwab, B., L. Costa, et al., "Muscarinic Receptor Alterations as a Mechanism of Anticholinesterase Tolerance," Toxicol Appl Pharmacol, 71, 1983, pp. 14-23.

Schwartz, R., and K. Kellar, "Cholinergic Receptor Binding Sites in Brain: Regulation in Vivo," Science, 220, 1983, pp. 214-216.

Schwartz, R., and K. Kellar, "In Vivo Regulation of [3H] Acetylcholine Recognition Sites in Brain by Nicotinic Cholinergic Drugs," J Neurochemistry, 45, 1985, pp. 427-433.

Schwartz, R. B., A. L. Komaroff, et al., "SPECT Imaging of the Brain: Comparison of Findings in Patients with Chronic Fatigue Syndrome, AIDS Dementia Complex, and Major Unipolar Depression," AJR Am J Roentgenol, 162(4), 1994, pp. 943-951.

Schwarz, M., D. Glick, et al., "Engineering of Human Cholinesterases Explains and Predicts Diverse Consequences of Administration of Various Drugs and Poisons," Pharmacol Ther, 67(2), 1995, pp. 283-322.

Schwarz, M., Y. Loewenstein-Lichtenstein, et al., "Successive Organophosphate Inhibition and Oxime Reactivation Reveals Distinct Responses of Recombinant Human Cholinesterase Variants," Molecular Brain Res, 31(2), 1995, pp. 101-110.

Scott, M. H. W. Reading, and J. B. Loudon, "Studies on Human Platelets in Affective Disorder," Psychopharmacol, 60(2), 1979, pp. 131-135.

Scremin, O., K. Allen, et al., "Physostigmine Enhances Blood Flow-Metabolism Ratio in Neocortex," Neuropsychopharmacology, 1, 1988, pp. 297-303.

Segal, M., and J. M. Auerbach, "Muscarinic Receptors Involved in Hippocampal Plasticity," Life Sci, 60(13-14), 1997, pp. 1085-1091.

Sejnowski, T., personal communication, 1997.

Senanayake, N., "Polyneuropathy Following Insecticide Poisoning," J Neurol, 232, 1985, p. 203.

Senanayake, N., and L. Karielledde, "Neurotoxic Effects of Organophosphorus Insecticides. An Intermediate Syndrome," New Engl J Med, 316, 1987, pp. 761-763.

Shale, D., D. Lane, et al., "Air-Flow Limitation in Myasthenia Gravis: The Effect of Acetylcholinesterase Inhibitor Therapy on Air-Flow Limitation," Am Rev Respir Dis, 128, 1983, pp. 618-621.

Sharabi, Y., Y. L. Danon, et al., "Survey of Symptoms Following Intake of Pyridostigmine During the Persian Gulf War," Isr J Med Sci, 27, 1991, pp. 656-658.

Sharma, H., F. Nyberg, et al., "Histamine Modulates Heat Stress-Induced Changes in Blood-Brain Barrier Permeability, Cerebral Blood Flow, Brain Oedema and Serotonin Levels: An Experimental Study in the Young Rat," Neuroscience, 50, 1992, pp. 445-454.

Sharp, B., H. Beyer, et al., "Attenuation of the Plasma Prolactin Response to Restraint Stress After Acute and Chronic Administration of Nicotine to Rats," J Pharmacol Exp Therapeutics, 241(2), 1987, pp. 438-442.

Shaw, K.-P., Y. Aracava, et al., "The Reversible Cholinesterase Inhibitor Physostigmine Has Channel-Blocking and Agonist Effects on the Acetylcholine Receptor-Ion Channel Complex," Mol Pharmacol, 28(6), 1985, pp. 527-538.

Shays, C., statement, Subcommittee on Human Resources, House Committee on Government Reform and Oversight, 1997.

Sherby, S., A. Eldefrawi, et al., "Comparison of Actions of Carbamate Anticholinesterases on the Nicotinic Acetylcholine Receptor," Mol Pharmacol, 27, 1985, pp. 343-348.

Shih, T., "Time-Course Effects of Soman on Acetylcholine and Choline Levels in Six Discrete Areas of the Rat Brain," Psychopharmacology, 78, 1982, pp. 170-175.

Shiloff, J., and J. Clement, "Effects of Subchronic Pyridostigmine Pretreatment on the Toxicity of Soman," Can J Physiol Pharmacol, 64, 1986, pp. 1047-1049.

Shipley, M., "Transport of Molecules from Nose to Brain: Transneuronal Antegrade and Retrograde Labeling in the Rat Olfactory System by Wheat Germ Agglutinin-Horseradish Peroxidase Applied to the Nasal Epithelium," Brain Res Bull, 15, 1985, pp. 129-142.

Shytle, R., A. Silver, et al., "Transdermal Nicotine for Tourette's Syndrome," Drug Dev Res, 38, 1996, pp. 290-298.

Sidell, F., clinical notes on chemical casualty care: pyridostigmine, Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, Department of the Army, 1990.

Sidell, F. R., and J. Borak, "Chemical Warfare Agents: II Nerve Agents," Ann Emergency Med, 21(7), 1992, pp. 865-871.

Sidell, F., and W. Groff, "The Reactivatability of Cholinesterase Inhibited by VX and Sarin in Man," Toxicol Appl Pharm, 27, 1974, pp. 241-252.

Sillanpaa, M. C., L. M. Agar, et al., "Gulf War Veterans: A Neuropsychological Examination," J Clin Exp Neuropsychol, 19(2), 1997, pp. 211-219.

Silver, W., and J. Maruniak, "Trigeminal Chemoreception in the Nasal and Oral cavities," Chemical Senses, 6(4), 1981, pp. 295-305.

Silverstein, M. D., B. A. Lashner, and S. B. Hanauer, "Cigarette Smoking and Ulcerative Colitis: A Case-Control Study," Mayo Clin Proc, 69(5), 1994, pp. 425-429.

Simasko, S., J. Soares, et al., "Two Components of Carbamylcholine-Induced Loss of Nicotinic Acetylcholine Receptor Function in the Neuronal Cell Line PC12," Mol Pharmacol, 30, 1986, pp. 6-12.

Simon, G., W. Daniell, et al., "Immunologic, Psychological, and Neuropsychological Factors in Multiple Chemical Sensitivity," Annals of Internal Medicine, 19(2), 1993, pp. 97-103.

Simon, T., D. Hickey, et al., "Single Photon Emission Computed Tomography of the Brain in Patients with Chemical Sensitivities," Toxicol Ind Health, 10(4/5), 1994, pp. 573-577.

Sitaram, N., and J. Gillin, "Acetylcholine: Possible Involvement in Sleep and Analgesia," in K. L. Davis and P. A. Berger, eds., Brain Acetylcholine and Neuropsychiatric Disease, New York: Plenum Press, 1979, pp. 311-343.

Sitaram, N., and J. Gillin, "Development and Use of Pharmacological Probes of the CNS in Man: Evidence of Cholinergic Abnormality in Primary Affective Illness," Biological Psychiatry, 15(6), 1980, pp. 925-955.

Sitaram, N., D. Jones, et al., "Supersensitive ACh REM Induction as a Genetic Vulnerability Marker," Int J Neurosci, 32, 1985, pp. 777-778.

Sitaram, N., D. Jones, et al., "The Association of Supersensitivie Cholinergic REM Induction and Affective Illness Within Pedigrees," J Psychiatr Res, 21, 1987, pp. 487-497.

Sitaram, N., J. Nurnberger, et al., "Cholinergic Regulation of Mood and REM Sleep. A Potential Model and Marker for Vulnerability to Depression," Am J Psychiatry, 139, 1982, pp. 571-576.

Smit, M., F. Ehlert, et al., "Decreased Agonist and Antagonist Binding to the Muscarinic Cholinergic Receptor Following Chronic Cholinesterase Inhibition," Fed Proc, 39, 1980a, p. 388.

Smit, M., F. Ehlert, et al., "Differential Regulation of Muscarinic Agonist Binding Sites Following Chronic Cholinesterase Inhibition," Eur J Pharmacol 66, 1980b, pp. 379-380.

Smith, A. P., "The Reversal by Pyridostigmine of Soman-Induced Neuromuscular Blockade in Primate Respiratory Muscle," Chemical Defence Establishment Technical Paper 302, Porton Down, U. K., 1981.

Smith, D., W. Stavinoha, et al., "Cholinesterase Inhibition in Relation to Fitness to Fly," Aerospace Med, 39, 1968, pp. 754-758.

Sneddon, J. M., "Blood Platelets as a Model for Monoamine-Containing Neurones," Prog Neurobiol, 1(2), 1973, pp. 151-198.

Snodgrass, H., "Permethrin Transfer from Treated Cloth to the Skin Surface: Potential for Exposure in Humans," J Toxicol Env Health, 35, 1992, pp. 91-105.

Snodgrass, H., D. Nelson, et al., "Dermal Penetration and Potential for Placental Transfer of the Insect Repellent, N,N-Diethyl-m-Toluamide," Am Ind Hyg Assoc J, 43, 1982, pp. 747-753.

Socci, D. J., P. R. Sanberg, and G. W. Arendash, "Nicotine Enhances Morris Water Maze Performance of Young and Aged Rats," Neurobiol of Aging, 16(5), 1995, pp. 857-860.

Soliman, S., "Comparative Studies in the Neurotoxicity of Organophosphorus Compounds in Different Animal Species," Neurotoxicology, 4(4), 1983, pp. 107-116.

Somani, S., "Binding of Quaternary Amines to Subcellular Constituents (Abstract)," Ind J Pharmacol, 1977.

Somani, S., "Metabolism and Pharmacokinetics of Pyridostigmine in Rat After Multiple Dosing," Pharmacologist, 25, 1983, p. 97.

Somani, S., "Gulf War Syndrome: Potential Effects of Low-Level Exposure to Sarin and/or Pyridostigmine Under Conditions of Physical Stress," testimony, Subcommittee on Human Resources, U.S. House of Representatives, 1997.

Somani, S. M., J. B. Roberts, et al., "Pyridostigmine Metabolism in Man," Clin Pharmacol Ther, 13, 1972, pp. 393-399.

Somnier, F. E., "Myasthenia Gravis," Dan Med Bull, 43(1), 1996, pp. 1-10.

Soreq, H., "Mutations and Impaired Expression in the AChE and BChE Genes: Neurological Implications," Biomed and Pharmacother, 48, 1994, pp. 253-259.

Soreq, H., "Cholinergic Symptoms and Gulf War Syndrome," Nature Medicine, 1(12), 1995, p. 1226.

Soreq, H., "Acetylcholinesterase: The Problem or the Solution?" (abstract), CDC Conference on The Health Impact of Chemical Exposures During the Gulf War, Atlanta, Ga., February 28-March 2, 1999.

Soreq, H., G. Ehrlich, et al., "Mutations and Impaired Expression in the AChE and BChE Genes: Neurological Implications," Biomed and Pharmacother, 48, 1994, pp. 253-259.

Sorlie, P. D., E. Adam, et al., "Cytomegalovirus/Herpesvirus and Carotid Atherosclerosis: The ARIC Study," J Med Virol, 42(1), 1994, pp. 33-37.

Sparks, P., W. Daniell, et al., "Multiple Chemical Sensitivity Syndrome: A Clinical Perspective I. Case Definition, Theories of Pathogenesis, and Research Needs," JOM, 36(7), 1994, pp. 718-737.

Spencer, T., J. Hill, et al., "Evaporation of Diethyltoluamide from Human Skin in Vivo and in Vitro," J Invest Dermatol, 72, 1979, pp. 317-319.

Sprague, G., L. Sandvik, et al., "Time-Course for Neurotoxic Esterase Inhibition in Hens Given Multiple Diisopropyl Fluorophosphate Injections," Neurotoxicology, 2, 1981, pp. 523-532.

Stallcup, W., and J. Patrick, "Substance P Enhances Cholinergic Receptor Desensitization in a Clonal Nerve Cell Line," Proc Natl Acad Sci USA, 77(1), 1980, pp. 634-638.

Stanton, M., W. Mundy, et al., "Time-Dependent Effects of Acute Chlorpyrifos Administration on Spatial Delayed Alternation and Cholinergic Neurochemistry in Weanling Rats," NeuroToxicology, 15(1), 1994, pp. 201-208.

Staudenmayer, H., and J. Selner, "Neuropsychology During Relaxation in Generalized, Universal `Allergic' Reactivity to the Environment: A Comparison Study," J Psychosom Res, 34(3), 1990.

Staudenmayer, H., J. Selner, et al., "Double-Blind Provocation Chamber Challenges in 20 Patients Presenting with `Multiple Chemical Sensitivity,'" Regulatory Toxicology and Pharmacology, 18(3), 1993, pp. 44-53.

Steenland, K., "Chronic Neurological Effect of Organophosphate Pesticides," BMJ, 312, 1996, pp. 1312-1313.

Steinberg, B., S. Weston, et al., "Affective Instability in Personality Disordered Patients Correlates with Mood Response to Physostigmine Challenge," Biol Psychiatry, 33, 1993, p. 86.

Stephens, R., A. Spurgeon, et al., "Organophosphates: The Relationship Between Chronic and Acute Exposure Effects," Neurotoxicology and Teratology, 18(4), 1996, pp. 449-453.

Stephenson, L., and M. Kolka, "Acetylcholinesterase Inhibitor, Pyridostigmine Bromide, Reduces Skin Blood Flow in Humans," U.S. Army Research Institute of Environmental Medicine, 1989.

Stephenson, L., and M. Kolka, "Acetylcholinesterase Inhibitor, Pyridostigmine Bromide, Reduces Skin Blood Flow in Humans," Am J Physiol, 71, 1990, pp. 432-437.

Stern, K., and M. McClintock, "Regulation of Ovulation by Human Pheromones," Nature, 392, 1998, pp. 177-179.

Sterri, S., S. Lyngas, et al., "Toxicity of Soman After Repetitive Injection of Sublethal Doses in the Rat," Acta Pharmacol Toxicol, 46, 1980, pp. 1-7.

Stewart, J., and I. Koplovitz, "The Effect of Pyridostigmine Pretreatment on the Efficacy of Atropine and Oxime Treatment of Cyclohexylmethylphosphonofluroidate (CMFF) Poisoning in Rodents," Aberdeen Proving Ground, Md., U.S. Army Medical Research Institute of Chemical Defense, 1993.

Stokes, L., A. Stark, et al., "Neurotoxicity Among Pesticide Applicators Exposed to Organophosphates," Occupational and Environmental Medicine, 52, 1995, pp. 648-653.

Stoller, A., J. Krupinski, et al., "Organophosphorous Insecticides and Major Mental Illness: An Epidemiological Investigation," Lancet, i, 1965, pp. 1387-1388.

Stoohs, R., C. Guilleminault, et al., "Traffic Accidents in Commercial Long-Haul Drivers: The Influence of Sleep-Disordered Breathing and Obesity," Sleep, 17(7), 1994, pp. 619-623.

Storzbach, D., L. Binder, et al., Objective Cognitive Performance of Persian Gulf War Veterans with High Scores on Measures of Post-Traumatic Stress Symptoms, Conference on Federally Sponsored Gulf War Veterans' Illnesses Research, June 17-19, 1998, Pentagon City, Va.

Stretch, R., P. Bliese, et al., "Physical Health Symptomatology of Gulf War-Era Service Personnel from the States of Pennsylvania and Hawaii," Milit Medicine, 160, 1995, pp. 131-136.

Stretch, R., P. Bliese, et al., "Post-Traumatic Stress Disorder Symptoms Among Gulf War Veterans," Milit Medicine, 161, 1996a, pp. 407-410.

Stretch, R., P. Bliese, et al., "Psychological Health of Gulf War-Era Military Personnel," Milit Medicine, 161, 1996b, pp. 257-261.

Streufert, S., R. Pogash, et al., "Effects of Caffeine Deprivation on Complex Human Functioning," Psychopharmacol, 118(4), 1995a, pp. 377-384.

Streufert, S., R. Pogash, et al., "Alcohol Hangover and Managerial Effectiveness," Alcohol, Clin and Experimental Res, 19(5), 1995b, pp. 1141-1146.

Streufert, S., U. Satish, et al., "Excess Coffee Consumption in Simulated Complex Work Settings: Detriment or Facilitation of Performance?" J Appl Psychology, 82(5), 1997, pp. 774-782.

Subcommittee on Human Resources, "Gulf War Veterans' Illnesses: VA, DoD Continue to Resist Strong Evidence Linking Toxic Causes to Chronic Health Effects," House Committee on Government Reform and Oversight, 1997.

Subcommittee on Human Resources, "Status of Efforts to Identify Persian Gulf War Syndrome," House Committee on Government Reform and Oversight. 1997.

Sugiyama, S., T. Kato, et al., "Deterioration of Mitochondrial Function in Heart Muscles of Rats with Hypothyroidism," J Clin Biochem Nutr, 11, 1991, pp. 199-204.

Sultan, W., and W. Lennox, "Comparison of the Efficacy of Various Therapeutic Regimens, with and Without Pyridostigmine Prophylaxis, for Soman (GD) Poisoning in Mice and Rabbits," Aberdeen Proving Ground, Md.: U.S. Army Chemical Systems Laboratory, 1983.

Sumpter-Loebig, S., prepared statement of Sgt. Susan Sumpter-Loebig, U.S. Army (Ret.), Subcommittee on Human Resources, House Committee on Government Reform and Oversight, 1997.

Sutker, P. B., M. Uddo, et al., "Psychopathology in War-Zone Deployed and Nondeployed Operation Desert Storm Troops Assigned Graves Registration Duties," J Abnorm Psychol, 103(2), 1994, pp. 383-390.

Swamy, K. V., R. Ravikumar, and P. M. Mohan, "Changes in Cholinesterase System in Different Brain Areas During the Development of Behavioral Tolerance to Monocrotophos Toxicity in Male Albino Rats," Biochem Int, 27(4), 1992, pp. 661-669.

Tabershaw, I., and W. Cooper, "Sequelae of Acute Organic Phosphate Poisoning," J Occup Med, 8, 1966, pp. 5-20.

Talbot, B., D. Anderson, et al., "A Comparison of in Vivo and in Vitro Rates of Aging of Soman-Inhibited Erythrocyte Acetylcholinesterase in Different Animal Species," Drug Chem Toxicol, 11, 1988, pp. 289-305.

Tammings, C., R. Smith, et al., "Depression Associated with Oral Choline," Lancet, 2, 1976, p. 905.

Tandon, P., S. Padilla, et al., "Fenthion Produces a Persistent Decrease in Muscarinic Receptor Function in the Adult Rat Retina," Toxicol Appl Pharmacol, 125, 1994, pp. 271-280.

Tandon, P., S. Willig, et al., "Dose-Response Study of the Tissue-Specific Effects of Fenthion on Receptor Function in Rat CNS," Toxicologist, 14, 1994, p. 257.

Tankersley, M., K. Smith, et al., "Petition to Repeal the Interim Rule," 1996, pp. 1-27.

Tavitian, B., S. Pappata, et al., "In Vivo Visualization of Acetylcholinesterase with Positron Emission Tomography," Neuroreport, 4, 1993, pp. 535-538.

Tavitian, B., S. Pappata, et al., "Binding Characteristics of [11C]physostigmine, a PET Tracer for Acetylcholinesterase (abstract)," J Cereb Blood Flow Metab, 15(Suppl), 1995, p. S122.

Taylor, P., and J. Brown, "Acetylcholine," in G. Siegel, B. Agranoff, R. Albers, and P. Molinoff, eds., Basic Neurochemistry, New York: Raven Press, 1994, Chapter 11, pp. 231-260.

Taylor, J., E. El-Fakahany, et al., "Long-Term Regulation of Muscarinic Receptors on Cultured Nerve Cells," Life Sci, 25, 1979, pp. 2181-2187.

Teichman, S., A. Ferrick, et al., "Disopyramide-Pyridostigmine Interaction: Selection Reversal of Anticholinergic Symptoms with Preservation of Antiarrhythmic Effect," JACC, 10, 1987, pp. 633-641.

Thakore, J., and T. Dinan, "Loss of the Diurnal Variation of Pyridostigmine-Induced Growth Hormone Responses in Depression: The Effect of Cortisol," International Clin Psychopharmacology, 10, 1995, pp. 107-110.

Thomas, G. A., J. Rhodes, et al., "Nicotine and Gastrointestinal Disease," QJM, 89(7), 1996, pp. 485-488.

Thomas, G. A., J. Rhodes, et al., "Inflammatory Bowel Disease and Smoking--A Review," Am J Gastroenterol, 93(2), 1998, pp. 144-149.

Thomas, G. A., J. Rhodes, et al., "Transdermal Nicotine as Maintenance Therapy for Ulcerative Colitis," New Engl J Med, 332(15), 1995, pp. 988-992.

Thompson, M., "The Silent Treatment," Nation, 148(28), 1996.

Thomsen, T., H. Kewitz, and O. Pleul, "Estimation of Cholinesterase Activity in Undiluted Plasma and Erythrocytes as a Tool for Measuring in Vivo Effect of Reversible Inhibitors," J Clin Chem Clin Biochem, 26(7), 1988, pp. 469-475.

Tiedt, T., Gulf War Syndrome testimony, Human Resources Subcommittee, House Government Reform and Oversight Committee, 1994.

Tiedt, T., E. Albuquerque, et al., "Neostigmine-Induced Alterations at the Mammalian Neuromuscular Junction I. Muscle Contraction and Electrophysiology," J Pharmacol Exp Therapeutics, 205(2), 1978, pp. 326-339.

Tiersky, L., B. Natelson, et al., "Functional Status and Mood in Gulf War Veterans (GWVs) with Fatiguing Illness," conference on Federally Sponsored Gulf War Veterans' Illnesses Research, Arlington, Va., June 17-19, 1998.

Tizabi, Y., D. H. Overstreet, et al., "Antidepressant Effects of Nicotine in an Animal Model of Depression," Psychopharmacol, 142(2), 1999, pp. 193-199.

Toth, L., S. Karcsu, et al., "Histochemical Evidence for the Role of Ca2+ and Neutral Protease in the Development of the Subacute Myopathy Induced by Organophosphorous Compounds," Acta Histochem, 72, 1983, pp. 71-75.

Trainer, P., J. Kirk, et al., "Pyridostigmine Partially Reverses Dexamethasone-Induced Inhibition of the Growth Hormone Response to Growth Hormone-Releasing Hormone," J Endocrinology, 134, 1991, pp. 513-517.

Trasforini, G., A. Margutti, et al., "Evidence that Enhancement of Cholinergic Tone Increases Basal Plasma Levels of Calcitonin Gene-Related Peptide in Normal Man," J Clin Endocrinology and Metabolism, 78(3), 1994, pp. 763-766.

Trojan, D., and N. Cashman, "Anticholinesterases in Post-Poliomyelitis Syndrome," Ann NY Acad Sci, 753, 1995, pp. 285-295.

Trojan, D., and N. Cashman, "An Open Trial of Pyridostigmine in Post-Poliomyelitis Syndrome," Canadian J of Neurological Sciences, 22(3), 1995, pp. 223-227.

Tuitte, J. I., "Second Staff Report on US Chemical and Biological Warfare-Related Dual-Use Exports to Iraq and the Possible Impact on the Health Consequences of the War (Updated April 25, 1997)," 1997.

Tuomisto, J. E. Tukiainen, and U. G. Ahlfors, "Decreased Uptake of 5-Hydroxytryptamine in Blood Platelets from Patients with Endogenous Depression," Psychopharmacol, 65(2), 1979, pp. 141-147.

Uchida, S., K. Takeyasu, et al., "Changes in Muscarinic Acetylcholine Receptors of Mice by Chronic Administration of Diisopropylfluorophosphate and Papaverine," Life Sci, 24, 1979, pp. 1805-1812.

"UN Inspectors in Iraq Found VX Nerve Gas Production,", posted June 24, 1998.

Unwin, C., N. Blatchley, et al., "Health of UK Servicemen Who Served in the Persian Gulf War," Lancet, 353, 1999, pp. 169-178.

U.S. Army Medical Research Institute of Chemical Defense, "219. Pretreatment," Medical Management of Chemical Casualties Handbook, accessed from Internet, 1997.

U.S. Department of Defense, "Immunizations and Chemoprophylaxis," 1995.

U.S. Environmental Protection Agency, "Technical Support Document on Risk Assessment of Chemical Mixtures," 1988.

Uyama, O., et al., "Quantitative Evaluation of Vascular Permeability in the Gerbil Brain After Transient Ischemia Using Evans Blue Fluorescence," J Cerebral Blood Flow Metab. 8, 1988, pp. 282-284.

Vaer¿y, H., R. Helle, et al., "Cerebrospinal Fluid Levels of §-Endorphin in Patients with Fibromyalgia (Fibrositis Syndrome)," J Rheumatol, 15(12), 1988, pp. 1804-1806.

Vaer¿y, H., R. Helle, et al., "Elevated CSF Levels of Substance P and High Incidence of Raynaud Phenomenon in Patients with Fibromyalgia: New Features for Diagnosis," Pain, 32(1), 1988, pp. 21-26.

Vaiseman, N., G. Koren, et al., "Pharmacokinetics of Oral and Intravenous Bromide in Normal Volunteers," Clinical Toxicology, 24(5), 1986, pp. 403-413.

Valcavi, R., M. Zini, et al., "The Late Growth Hormone Rise Induced by Oral Glucose Is Enhanced by Cholinergic Stimulation with Pyridostigmine in Normal Subjects," Clinical Endocrinology, 37, 1992, pp. 360-364.

Valcavi, R., O. Gaddi, et al., "Cardiac Performance and Mass in Adults with Hypopituitarism: Effects of One Year of Growth Hormone Treatment," J Clin Endocrinology and Metabolism, 80(2), 1995, pp. 659-666.

Vannucchi, M. G., C. Scali, et al., "Selective Muscarinic Antagonists Differentially Affect in Vivo Acetylcholine Release and Memory Performances of Young and Aged Rats," Neuroscience, 79(3), 1997, pp. 837-846.

Vasterling, J. J., K. Brailey, et al., "Attention and Memory Dysfunction in Posttraumatic Stress Disorder," Neuropsychology, 12(1), 1998, pp. 125-133.

Velicky, J., M. Titlbach, et al., "Potassium Bromide and the Thyroid Gland of the Rat: Morphology and Immunohistochemistry, RIA and INAA analysis," Anat Anz, 179(5), 1997, pp. 421-431.

Velicky, J., M. Titlbach, et al., "Long-Term Action of Potassium Bromide on the Rat Thyroid Gland," Acta Histochem, 100(1), 1988, pp. 11-23.

Velicky, J., M. Titlbach, et al., "Expression of the Proliferating Cell Nuclear Antigen (PCNA) in the Rat Thyroid Gland After Exposure to Bromide," Acta Histochem, 99(4), 1997, pp. 391-399.

Verschoyle, R., A. Brown, et al., "A Comparison of the Acute Toxicity, Neuropathology, and Electrophysiology of N, N-Diethyl-m-Toluamine and N, N-Dimethyl-2,2-Diphenylacetamide in Rats," Fundam Appl Toxicol, 18, 1990, pp. 79-88.

Viby-Mogensen, J., "Succinylcholine Neuromuscular Blockade in Subjects Heterozygous for Abnormal Plasma Cholinesterase," Anesthesiology, 55, 1981, p. 235.

Visseren, F. L., K. P. Bouter, et al., "Patients with Diabetes Mellitus and Atherosclerosis; A Role for Cytomegalovirus?" Diabetes Res Clin Pract, 36(1), 1997, pp. 49-55.

Vizi, E. S., L. G. Harsing, Jr., and G. Zsilla, "Evidence of the Modulatory Role of Serotonin in Acetylcholine Release from Striatal Interneurons," Brain Res, 212(1), 1981, pp. 89-99.

Vobecky, M., and A. Babicky, "Effect of Enhanced Bromide Intake on the Concentration Ratio I/Br in the Rat Thyroid Gland," Biol Trace Elem Res, 43(45), 1994, pp. 509-516.

Vobecky, M., A. Babicky, et al., "Effect of Increased Bromide Intake on Iodine Excretion in Rats," Biol Trace Elem Res, 55(3), 1996, pp. 215-219.

Vobecky, M., A. Babicky, et al., "Interaction of Bromine with Iodine in the Rat Thyroid Gland at Enhanced Bromide Intake," Biol Trace Elem Res, 54(3), 1996, pp. 207-212.

von Bredow, J., J. Jaxx, et al., "Estimate of the Lowest Dose of Diazepam Required to Treat Soman-Induced Convulsions in Pyridostigmine Pretreated, Atropine, Pralidoxime Chloride and Diazepam Treated Rhesus Monkeys," Aberdeen Proving Ground, Md.: U.S. Army Medical Research Institute of Chemical Defense, 1988.

von Bredow, J. D., N. L. Adams, et al., "Effectiveness of Oral Pyridostigmine Pretreatment and Cholinolytic-Oxime Therapy Against Soman Intoxication in Nonhuman Primates," Fundam Appl Toxicol, 17, 1991, pp. 761-770.

von Bredow, J., R. McGarrigle, et al., "Carbamate and Anticholinergic Prophylaxis Against Multilethal Concentrations of Soman in Primates," Pharmacologist, 24, 1982, p. 220.

von Mayersbach, H., "Circadian Liver Detoxification and Acetylcholinesterase Rhythmicity: Two Limiting Factors in Circadian E600 Toxicity," in L. Scheving, F. Halberg, and J. Pauly, eds., Chronobiology, Tokyo: Igaku Shoin, Ltd., 1974.

Wacks, I., J. Oster, et al., "Spurious Hyperchloremia and Hyperbicarbonatemia in a Patient Receiving Pyridostigmine Bromide Therapy for Myasthenia Gravis," Am J Kidney Diseases, XVI(1), 1990, pp. 76-79.

Wada, K., M. Ballivet, et al., "Functional Expression of a New Pharmacological Subtype of Brain Nicotinic Acetylcholine Receptor," Science, 240, 1987, pp. 330-334.

Wada, E., K. Wada, et al., "Distribution of Alpha2, Alpha3, Alpha4, and Beta2 Neuronal Nicotinic Receptor Subunit mRNAs in the Central Nervous System: A Hybridization Histochemical Study in the Rat," J Comparative Neurology, 284, 1989, pp. 314-335.

Wada, K., D. McKinnon, et al., "The Distribution of mRNA Encoded by a New Member of the Neuronal Nicotinic Acetylcholine Receptor Gene Family (Alpha5) in the Rat Central Nervous System," Brain Res, 526, 1990, pp. 45-53.

Wali, S. O., and M. H. Kryger, "Medical Treatment of Sleep Apnea," Curr Opin Pulm Med, 1(6), 1995, pp. 498-503.

Walsh, T., and D. Emerich, "The Hippocampus as a Common Target of Neurotoxic Agents," Toxicol, 49, 1988, pp. 137-140.

Wannarka, G., "Status of the Pyridostigmine Development Effort," 4th Annual Defense Bioscience Review, 1984, pp. 107-120.

Watanabe, K., and H. Kang, "Military Service in Vietnam and the Risk of Death from Trauma and Selected Cancers," AEP, 5(5), 1995, pp. 407-412.

Watson, J. P., and R. A. Lewi, "Ulcerative Colitis Responsive to Smoking and to Nicotine Chewing Gum in a Patient with Alpha 1 Anti-Trypsin Deficiency," Respir Med 89(9), 1995, pp. 635-636.

Wecker, L., and W.-D. Dettbarn, "Paraoxon-Induced Myopathy: Muscle Specificity and Acetylcholine Involvement," Experimental Neurology, 51, 1976, pp. 281-291.

Wehrenberg, W., S. Wiviott, et al., "Pyridostigmine-Mediated Growth Hormone Release: Evidence for Somatostatin Involvement," Endocrinology, 130(3), 1992, pp. 1445-1450.

Wenger, B., M. D. Quigley, et al., "Seven-Day Pyridostigmine Administration and Thermoregulation During Rest and Exercise in Dry Heat," Aviat Space Environ Med, October 1993, pp. 905-911.

Wenger, C., and W. Latzka, "Effects of Pyridostigmine Bromide on Physiological Response to Heat, Exercise, and Hypohydration," Aviat Space Environ Med, 63(1), 1992, pp. 37-45.

Wertlake, P., A. Wilcox, et al., "Relationship of Mental and Emotional Stress to Serum Cholesterol Levels," Proc Soc Exper Biol & Med, 97, 1958, p. 163.

Westbrook, G., Regulation of Glutamate Channels at Central Synapses, International Symposium on the Cholinergic Synapse: Structure, Function and Regulation (3rd), University of Maryland, Baltimore, 1994.

Westernick, B., and J. Korf, "Influence of Drugs on Striatal and Limbic Homovanillic Acid Concentration in the Rat Brain," Eur J Pharmacol, 33, 1975, p. 31.

Westfall, T. C., H. Grant, and H. Perry, ""Release of Dopamine and 5-Hydroxytryptamine from Rat Striatal Slices Following Activation of Nicotinic Cholinergic Receptors," General Pharmacol, 14(3), 1983, pp. 321-325.

Wetherell, A., "Car Driver Behaviour Following Pyridostigmine Bromide Administration," Chemical Defence Establishment, Porton Down, U.K., 1988.

Wetherell, A., "Cognitive and Psychomotor Effects of Nerve Agent Immediate Treatments Containing 10 and 15 mg TL4914 Preceded by Two Days' Pretreatment with Pyridostigmine Bromide," Chemical Defence Establishment, Porton Down, U.K., 1988.

Wetherell, A., "Cognitive and Psychomotor Performance Tests and Experiment Design in Multiple Chemical Sensitivity," Environ Health Perspect, 105, Supplement 2, 1997, pp. 495-503.

Wetherell, A., "A Comparison of the Effects on Human Behaviour of Nerve Agent Immediate Treatment Containing 5 mg Diazepam with That Containing 15 mg TL4914," Chemical Defence Establishment, Porton Down, U.K., 1984.

Wetherell, A., "Effects of 5mg Diazepam and 15 and 30 mg TL4914 on Human Cognitive and Psychomotor Performance," Chemical Defence Establishment, Porton Down, U.K., 1984.

Wetherell, A., and J. Wainwright, "Comparative Effects on Human Behaviour of the Current Nerve Agent Immediate Treatment Incorporating 5mg Diazepam and the Proposed Treatment Incorporating 10mg TL4914," Chemical Defence Establishment, Porton Down, U.K., 1985.

Wetherell, J., "The Development of Pyridostigmine as a Nerve Agent Pretreatment," Technical Note 1296, Chemical Defence Establishment, Porton Down, U.K., 1992.

Wetherell, J., and M. French, "The Hydrolysis of Succinyuldithiocholine and Related Thiocholine Esters by Human Plasma and Purified Cholinesterase," Biochem Pharmacol, 35(6), 1986, pp. 939-945.

Wetherell, J., and M. French, "A Comparison of the Decarbamoylation Rates of Physostigmine-Inhibited Plasma and Red Cell Cholinesterases of Man with Other Species," Biochem Pharmacol 42, 1991, pp. 515-520.

Whetsell, W., "Current Concepts of Excitotoxicity," J of Neuropathology and Experimental Neurology, 55(1), 1996, pp. 1-13.

Whinnery, J., "Pyridostigmine Bromide: A Pre-Exposure Antidote for Specific Chemical Warfare Nerve Agents: A Condensed Review for the Aeromedical Specialist," USAF School of Aerospace Medicine, Brooks AFB, Tex., 1984.

White, R. F., M. Krengel, et al., "Neuropsychological Findings Among Persian Gulf War Veterans" (abstract), conference on Federally Sponsored Gulf War Veterans' Illnesses Research, June 17-19, 1998, p. 76.

Whybrow, P., and J. Ewing, "Self Perpetuation of Bromism," Brit Med J, 2, 1966, p. 886.

Wiley, R., J. Kotulak, et al., "The Effects of Pyridostigmine Bromide on Visual Performance," Aviat Space Environ Med, 63, 1992, pp. 1054-1059.

Williams, F., "Clinical Significance of Esterase in Man," Clin Pharmacokinet, 10, 1987, pp. 392-405.

Williams, J., "Human Response to Pyridostigmine Bromide," Air Force Aerospace Medical Research Laboratory, Dayton, Ohio, 1984.

Wills, J., "Pharmacological Antagonists of the Anticholinesterase Agents," in G. Koelle, ed., Cholinesterases and Anticholinesterase Agents, Berlin: Springer-Verlag, 1963, p. 896.

Wills, M., and J. Savory, "Aluminium Poisoning: Dialysis Encephalopathy, Osteomalacia, and Anaemia," Lancet, 2, 1983, pp. 29-33.

Wilson, J., E. Braunwald, et al., eds., Harrison's Principles of Internal Medicine, New York: McGraw-Hill, 1991.

Wimmer, M. L., R. Sandmann-Strupp, et al., "Association of Chlamydial Infection with Cerebrovascular Disease," Stroke, 27(12), 1996, pp. 2207-2210.

Winbladh, B., "Choroid Plexus Uptake of Acetylcholine," Acta Physiol Scand, 92, 1974, pp. 156-164.

Windheuser, J., J. Haslam, et al., "The Use of N,N- Diethyl-m-Toluamide to Enhance the Dermal and Transdermal Delivery of Drugs," J Pharmacol Sci, 71, 1982, pp. 1211-1213.

Wirth, J. A., "Organic Psychosyndrome and Sleep Apnea. Transdermal Nicotine--a New Therapy Concept?" Pneumologie, 49, 1995, Supplement 1, pp. 183-184.

Wolfe, A., D. Blick, et al., "Use of Cholinesterases as Pretreatment Drugs for the Protection of Rhesus Monkeys Against Soman Toxicity," Toxicol Appl Pharmacol, 117, 1992, pp. 189-193.

Wolfe, J., S. Proctor, et al., Relationship of PTSD and Depression to Persian Gulf Health Problems, Conference on Federally Sponsored Gulf War Veterans' Illnesses Research, June 17-19, 1998a, Pentagon City, Va.

Wolfe, J., S. Proctor, et al., "Re: `Is Gulf War Syndrome Due to Stress? The Evidence Reexamined' (letter)," Am J Epidem 148(4), 1998b, p. 402.

Wolfe, J., S. Proctor, et al., "Health Symptoms Reported by Persian Gulf War Veterans Two Years After Return," Amer J Ind Med, 33, 1998c, pp. 104-113.

Wolthius, O., B. Groen, et al., "Effects of Low Doses of Cholinesterase Inhibitors on Behavioral Performance of Robot-Tested Marmosets," Pharmacol Biochem Behav, 51(2/3), 1995, pp. 443-456.

Wonnacott, S., D. Marshal, et al., Presynaptic Nicotinic Receptor Modulation of Dopamine Release in Rat Brain, International Symposium on the Cholinergic Synapse: Structure, Function and Regulation (3rd), University of Maryland, Baltimore, 1994.

Worek, F., and L. Szinicz, "Cardiorespiratory Function in Nerve Agent Poisoned and Oxime+Atropine Treated Guinea-Pigs: Effect of Pyridostigmine Pretreatment," Arch Toxicol, 69(5), 1995, pp. 322-329.

Worek, F., A. Kleine, et al., "Effect of Pyridostigmine Pretreatment on Cardiorespiratory Function in Tabun Poisoning," Human and Experimental Toxicology, 14, 1995, pp. 634-642.

Writer, J., R. De Fraites, et al., "Comparative Mortality Among U.S. Military Personnel in the Persian Gulf Region and Worldwide During Operations Desert Shield and Desert Storm," JAMA, 275, pp. 118-121.

Yamaguchi, M., R. Robson, et al., "Properties of Soleus Muscle Z-Lines and Induced Z-Line Analogs Revealed by Dissection with Ca2+-Activated Neutral Protease," Anat Rec, 206, 1983, pp. 345-362.

Yamamoto, K., Y. Sawada, et al., "Comparative Pharmacokinetics of Four Cholinesterase Inhibitors in Rats," Biol Pharm Bull, 18(9), 1995, pp. 1292-1295.

Yamamura, H., and S. Snyder, "Muscarinic Cholinergic Binding in Rat Brain," Proc Nat Acad Sci USA, 71(5), 1974, pp. 1725-1729.

Yanaura, M., M. Nakashima, et al., "Characterization of Slow Presynaptic Current of Apyslia LUQ Neurons in Culture," Brain Res, 629(1), 1993, pp. 88-94.

Yang, I., J. Woo, et al., "Combined Pyridostigmine-Thyrotrophin-Releasing Hormone Test for the Evaluation of Hypothalamic Somatostatinergic Activity in Healthy Normal Men," Eur J Endocrinology, 133, 1995, pp. 457-462.

Yonemitsu, Y., Y. Kaneda, et al., "The Immediate Early Gene of Human Cytomegalovirus Stimulates Vascular Smooth Muscle Cell Proliferation in Vitro and in Vivo," Biochem Biophys Res Commun, 231(2), 1997, pp. 447-451.

Young, G. D., "Pyridostigmine Bromide Interactive Studies: A Synopsis of Past, Current, and Future Studies," Directorate of Toxicology, USACHPPM, undated.

Young, J., "Desensitization and Agonist Binding to Cholinergic Receptors in Intestinal Smooth Muscle," FEBS Lett, 46, 1974, pp. 354-356.

Young, R., R. Rachal, and J. W. Huguley III, "Environmental Health Concerns of the Persian Gulf War," J National Med Assoc, 84(5), 1992, pp. 417-424.

Zadikoff, C., "Toxic Encephalopathy Associated with Use of Insect Repellent," J Pediatr, 95, 1979, pp. 140-142.

Zarrindast, M. R., M. Sadegh, and B. Shafaghi, "Effects of Nicotine on Memory Retrieval in Mice," Eur J Pharmacol, 295(1), 1996, pp. 1-6.

Zeller, M., prepared statement of SSgt. Mark J. Zeller before the Subcommittee on Human Resources, House Committee on Government Reform and Oversight, 1997.

Zhou, Y. F., E. Guetta, et al., "Human Cytomegalovirus Increases Modified Low Density Lipoprotein Uptake and Scavenger Receptor mRNA Expression in Vascular Smooth Muscle Cells," J Clin Invest, 98(9), 1996, pp. 2129-2138.

Ziem, G., "Multiple Chemical Sensitivity: Treatment and Followup with Avoidance and Control of Chemical Exposures," Toxicol Ind Health, 8, 1992, pp. 73-86.

Ziem, G., and J. McTamney, "Profile of Patients with Chemical Injury and Sensitivity," Environmental Health Perspectives, 105, 1997, Supplement 2, pp. 417-436.

Zoler, M., "Vagal-Nerve Stimulation Needs Tweaking," Internal Medicine News, 1998, p. 21.

Zuckerman, D., P. Olson, et al., "Is Military Research Hazardous to Veterans' Health? Lessons from the Persian Gulf," accessed from the Internet, 1994.

Appendix C