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Assessment of Genomic Instability via Chromosome 7 Inversion Frequency in a Gulf-War Syndrome Cohort vs. Selected Control Groups |
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The study is designed to determine if a gene instability (chromosome 7 inversion) exist in Gulf War veterans and other groups who exhibit symptoms of autoimmune or collagen disease.
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| Project Number: | DoD-48
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| Status: | Complete
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| Period of Performance: | October 10,1995 - November 30,1997
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| Location: | Walter Reed Army Institute of Research
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| Cost to Date: | $74,000
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Autonomic Dysfunction in Gulf War Veterans |
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This study will analyze genes and measures of nervous system response in both of ill and healthy veterans, in order to determine whether some individuals may be more prone to develop Gulf War illnesses when exposed to certain forms of stress because their nervous system reacts differently.
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| Project Number: | DoD-111
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| Status: | Ongoing
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| Period of Performance: | January 31,2000 - June 30,2003
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| Location: | Midwest Research Institute
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| Cost to Date: | $999,481
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Butyrylcholinesterase Genetic Variants in Persons with Gulf War Illness |
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This study attempts to test theories that unexplained illnesses of Gulf War Veterans is a result of nerve damage caused by exposures to nerve agents and the natural occurring enzyme Butyl cholinesterase.
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| Project Number: | DoD-60
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| Status: | Complete
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| Period of Performance: | September 30,1997 - March 31,1999
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| Location: | University of Nebraska Medical Center
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| Cost to Date: | $125,000
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DNA Damage from Chemical Agents and Its Repair (Project IV) |
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This animal and human study aims to determine the long-term consequences of Chemical Weapon exposure on nervous and non-nervous system tissue, and to establish a possible link between those exposures and DNA damage and repair.
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| Project Number: | VA-6D
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| Status: | Complete
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| Period of Performance: | October 01,1994 - March 31,2000
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| Location: | VAMC Portland
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| Cost to Date: | $2,829,069 for VA-6Core and VA-6A through VA-6E
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Do Defective Gpx1 and ALDH2 Genes Increase Sensitivity to Environmental Exposure |
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The objective of this study is to determine whether susceptibility to environmental exposure may result from defects in the expression of certain gene products.
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| Project Number: | VA-65D
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| Status: | Ongoing
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| Period of Performance: | January 07,2000 - January 07,2005
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| Location: | San Antonio Environmental
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| Cost to Date: | $666,750 for VA-65A through VA-65D
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Does a Variant of the Human SOD2 Gene Increase Sensitivity to Hazards? |
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This study attempts to assess whether mice with certain gene (SOD2) variants are more sensitive to oxidative stress.
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| Project Number: | VA-65A
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| Status: | Ongoing
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| Period of Performance: | January 07,2000 - January 07,2005
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| Location: | San Antonio Environmental
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| Cost to Date: | $666,750 for VA-65A through VA-65D
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Effects of Genetics and Stress on Responses to Environmental Toxins |
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The project sought to determine whether genetic susceptibility to stress and exposure to chronic stress resulted in heightened sensitivity to the effects of pyridostigmine bromide (PB), and hydrocarbons from oil well fires.
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| Project Number: | VA-5D
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| Status: | Complete
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| Period of Performance: | October 01,1994 - September 30,1997
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| Location: | VAMC East Orange
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| Cost to Date: | $2,926,900 for VA-5Core and VA-5A through VA-5D
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Effects of Pyridostigmine in Flinders Line Rats Differing in Cholinergic Sensitivity |
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An animal (rat) model study to predict and compare effects of pyridostigmine bromide (PB) administered for a short time and continually.
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| Project Number: | DoD-33
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| Status: | Complete
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| Period of Performance: | July 01,1996 - June 30,1999
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| Location: | University of North Carolina, Chapel Hill
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| Cost to Date: | $354,000
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Identification of the Genetic Factors Which Control Tropism in Leishmania |
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A study of the parasite leishmania identifies if there is a gene(s) causing temperature resistance or sensitivity, that may influence the parasite to remain in the skin or move to the viscera (large interior organs of the body, especially the abdomen).
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| Project Number: | DoD-9
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| Status: | Complete
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| Period of Performance: | July 01,1994 - July 01,1998
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| Location: | WRAIR, Brazilia
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| Cost to Date: | $150,000
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Molecular Regulation of Corticosteroid Receptor Expression in Stress-Responsive Cells |
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This study seeks an explanation of the body's mechanisms for dealing with stress by analyzing its effects in those stress-responsive tissues of the pituitary, hypothalamus, and adrenal glands.
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| Project Number: | DoD-80
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| Status: | Ongoing
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| Period of Performance: | February 01,1999 - January 31,2002
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| Location: | USUHS
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| Cost to Date: | $300,000
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Neurological and Circadian Substrates of PTSD-like Behaviors |
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This study attempts to determine if the development of post-traumatic stress disorder (PTSD) requires both a traumatic event and a genetic (neurological) susceptibility (since not all individuals who experience a traumatic event develop PTSD).
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| Project Number: | DoD-91
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| Status: | Ongoing
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| Period of Performance: | October 01,1998 - September 30,2001
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| Location: | Armstrong Lab
VAMC San Antonio
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| Cost to Date: | $599,000
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Study of Variability In Pyridostigmine Inhibition of Blood Cholinesterases in Healthy Adults and Individuals With Symptoms Following Participation in Operation Desert Storm |
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A comparative study between Gulf War veterans who took pyridostigmine bromide (PB) and a control group who did not to determine if there is a difference in their blood cholinesterase.
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| Project Number: | DoD-21
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| Status: | Complete
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| Period of Performance: | July 11,1995 - June 30,1997
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| Location: | Walter Reed Army Institute of Research
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| Cost to Date: | $138,000
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The Aromatic Hydrocarbon Receptor (AhR) as a Biomarker of Susceptibility |
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The primary goal of the project was to investigate the potential role of a particular protein in mediating the adverse biologic effects caused by exposure to hydrocarbons from oil well fires.
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| Project Number: | VA-4E
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| Status: | Complete
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| Period of Performance: | October 01,1994 - December 31,1999
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| Location: | VAMC Boston
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| Cost to Date: | $2,827,800 for VA-4Core and VA-4A through VA-4F
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The Contribution of FEN-1 to Genetic Integrity Subsequent to Oxidative Stress |
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The purpose of this study is to determine the effects of oxidative stressors in mice with a certain genetic (FEN-1) deficiency.
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| Project Number: | VA-65B
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| Status: | Ongoing
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| Period of Performance: | January 07,2000 - January 07,2005
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| Location: | San Antonio Environmental
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| Cost to Date: | $666,750 for VA-65A through VA-65D
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The Importance of Hydrogen Peroxide Detoxification in Cellular Protection |
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This study attempts to determine the importance of hydrogen peroxide detoxification in protecting mice against certain environmental hazards (such as ionizing radiation and paraquat).
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| Project Number: | VA-65C
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| Status: | Ongoing
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| Period of Performance: | January 07,2000 - January 07,2005
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| Location: | San Antonio Environmental
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| Cost to Date: | $666,750 for VA-65A through VA-65D
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Transgenic Engineering of Cholinesterases: Tools for Exploring Cholinergic Responses |
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The study looks at the various chemical enzymes that exists in the body in order to find a better means of protecting cells from the harmful effects of organophosphates.
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| Project Number: | DoD-51
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| Status: | Complete
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| Period of Performance: | October 01,1996 - February 28,2000
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| Location: | Hebrew University of Jerusalem
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| Cost to Date: | $864,000
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