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 Research Topics    |    Major Focus Areas    |    Reports
Research Topics
Health and Human Services Department of Defense Veterans Affairs Health and Human Services Gulf War Information Department of Defense Gulf War Information Veterans Affairs Gulf War Information Home Home Advanced Search Glossary FAQs Site Map Contact Us
 Research Topics    |    Major Focus Areas
Research Topics
ACCIDENTS & INJURIES
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GENETIC STUDIES
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Genetic Studies

Assessment of Genomic Instability via Chromosome 7 Inversion Frequency in a Gulf-War Syndrome Cohort vs. Selected Control Groups
The study is designed to determine if a gene instability (chromosome 7 inversion) exist in Gulf War veterans and other groups who exhibit symptoms of autoimmune or collagen disease.
Project Number:DoD-48
Status:Complete
Period of Performance:October 10,1995 - November 30,1997
Location:Walter Reed Army Institute of Research
Cost to Date: $74,000


Autonomic Dysfunction in Gulf War Veterans
This study will analyze genes and measures of nervous system response in both of ill and healthy veterans, in order to determine whether some individuals may be more prone to develop Gulf War illnesses when exposed to certain forms of stress because their nervous system reacts differently.
Project Number:DoD-111
Status:Ongoing
Period of Performance:January 31,2000 - June 30,2003
Location:Midwest Research Institute
Cost to Date: $999,481


Butyrylcholinesterase Genetic Variants in Persons with Gulf War Illness
This study attempts to test theories that unexplained illnesses of Gulf War Veterans is a result of nerve damage caused by exposures to nerve agents and the natural occurring enzyme Butyl cholinesterase.
Project Number:DoD-60
Status:Complete
Period of Performance:September 30,1997 - March 31,1999
Location:University of Nebraska Medical Center
Cost to Date: $125,000


DNA Damage from Chemical Agents and Its Repair (Project IV)
This animal and human study aims to determine the long-term consequences of Chemical Weapon exposure on nervous and non-nervous system tissue, and to establish a possible link between those exposures and DNA damage and repair.
Project Number:VA-6D
Status:Complete
Period of Performance:October 01,1994 - March 31,2000
Location:VAMC Portland
Cost to Date: $2,829,069 for VA-6Core and VA-6A through VA-6E


Do Defective Gpx1 and ALDH2 Genes Increase Sensitivity to Environmental Exposure
The objective of this study is to determine whether susceptibility to environmental exposure may result from defects in the expression of certain gene products.
Project Number:VA-65D
Status:Ongoing
Period of Performance:January 07,2000 - January 07,2005
Location:San Antonio Environmental
Cost to Date: $666,750 for VA-65A through VA-65D


Does a Variant of the Human SOD2 Gene Increase Sensitivity to Hazards?
This study attempts to assess whether mice with certain gene (SOD2) variants are more sensitive to oxidative stress.
Project Number:VA-65A
Status:Ongoing
Period of Performance:January 07,2000 - January 07,2005
Location:San Antonio Environmental
Cost to Date: $666,750 for VA-65A through VA-65D


Effects of Genetics and Stress on Responses to Environmental Toxins
The project sought to determine whether genetic susceptibility to stress and exposure to chronic stress resulted in heightened sensitivity to the effects of pyridostigmine bromide (PB), and hydrocarbons from oil well fires.
Project Number:VA-5D
Status:Complete
Period of Performance:October 01,1994 - September 30,1997
Location:VAMC East Orange
Cost to Date: $2,926,900 for VA-5Core and VA-5A through VA-5D


Effects of Pyridostigmine in Flinders Line Rats Differing in Cholinergic Sensitivity
An animal (rat) model study to predict and compare effects of pyridostigmine bromide (PB) administered for a short time and continually.
Project Number:DoD-33
Status:Complete
Period of Performance:July 01,1996 - June 30,1999
Location:University of North Carolina, Chapel Hill
Cost to Date: $354,000


Identification of the Genetic Factors Which Control Tropism in Leishmania
A study of the parasite leishmania identifies if there is a gene(s) causing temperature resistance or sensitivity, that may influence the parasite to remain in the skin or move to the viscera (large interior organs of the body, especially the abdomen).
Project Number:DoD-9
Status:Complete
Period of Performance:July 01,1994 - July 01,1998
Location:WRAIR, Brazilia
Cost to Date: $150,000


Molecular Regulation of Corticosteroid Receptor Expression in Stress-Responsive Cells
This study seeks an explanation of the body's mechanisms for dealing with stress by analyzing its effects in those stress-responsive tissues of the pituitary, hypothalamus, and adrenal glands.
Project Number:DoD-80
Status:Ongoing
Period of Performance:February 01,1999 - January 31,2002
Location:USUHS
Cost to Date: $300,000


Neurological and Circadian Substrates of PTSD-like Behaviors
This study attempts to determine if the development of post-traumatic stress disorder (PTSD) requires both a traumatic event and a genetic (neurological) susceptibility (since not all individuals who experience a traumatic event develop PTSD).
Project Number:DoD-91
Status:Ongoing
Period of Performance:October 01,1998 - September 30,2001
Location:Armstrong Lab
VAMC San Antonio
Cost to Date: $599,000


Study of Variability In Pyridostigmine Inhibition of Blood Cholinesterases in Healthy Adults and Individuals With Symptoms Following Participation in Operation Desert Storm
A comparative study between Gulf War veterans who took pyridostigmine bromide (PB) and a control group who did not to determine if there is a difference in their blood cholinesterase.
Project Number:DoD-21
Status:Complete
Period of Performance:July 11,1995 - June 30,1997
Location:Walter Reed Army Institute of Research
Cost to Date: $138,000


The Aromatic Hydrocarbon Receptor (AhR) as a Biomarker of Susceptibility
The primary goal of the project was to investigate the potential role of a particular protein in mediating the adverse biologic effects caused by exposure to hydrocarbons from oil well fires.
Project Number:VA-4E
Status:Complete
Period of Performance:October 01,1994 - December 31,1999
Location:VAMC Boston
Cost to Date: $2,827,800 for VA-4Core and VA-4A through VA-4F


The Contribution of FEN-1 to Genetic Integrity Subsequent to Oxidative Stress
The purpose of this study is to determine the effects of oxidative stressors in mice with a certain genetic (FEN-1) deficiency.
Project Number:VA-65B
Status:Ongoing
Period of Performance:January 07,2000 - January 07,2005
Location:San Antonio Environmental
Cost to Date: $666,750 for VA-65A through VA-65D


The Importance of Hydrogen Peroxide Detoxification in Cellular Protection
This study attempts to determine the importance of hydrogen peroxide detoxification in protecting mice against certain environmental hazards (such as ionizing radiation and paraquat).
Project Number:VA-65C
Status:Ongoing
Period of Performance:January 07,2000 - January 07,2005
Location:San Antonio Environmental
Cost to Date: $666,750 for VA-65A through VA-65D


Transgenic Engineering of Cholinesterases: Tools for Exploring Cholinergic Responses
The study looks at the various chemical enzymes that exists in the body in order to find a better means of protecting cells from the harmful effects of organophosphates.
Project Number:DoD-51
Status:Complete
Period of Performance:October 01,1996 - February 28,2000
Location:Hebrew University of Jerusalem
Cost to Date: $864,000