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Depleted Uranium
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Pyridostigmine Bromide

Toxicology

Benson, Kimberly A. et al. Neurotoxicity and Reproductive Effects of Embedded Depleted Uranium in the Rat. Armed Forces Radiobiology Research Institute. Because the effects of chronic exposure to uranium from depleted uranium fragments is unknown a study was conducted on rats to evaluate the kidney, reproductive system, behavioral tendencies and neural toxicity associated with embedded pellets. www.afrri.usuhs.mil/index.html

Drake-Baumann, Rosemarie et al. Effects of Exposure to Low-Dose Pyridostigmine on Neuromuscular Junctions In Vitro. Portland Environmental Health Research Center. Summarizes a study done to examine the effects of PB on neuromuscular function using 1-2 week exposure with low concentrations.

Fishbein, William N. et al. Masked Assay For Genomic Instability In a Gulf-War-Illness Group vs 3 Matched Control Groups. Walter Reed Army Medical Center. Summarizes a study done using a test for chromosome 7 to help determine if increased frequency of this chromosome may be a useful biomarker for genotoxic agents.

Henderson, R.F. et al Dosimtry of Inhaled Sarin. Lovelace Respiratory Research Institute. Discusses a study done to measure the distribution and tissue concentration of sarin in the brain of a rat following low levels of sarin by inhalation and the influence of heat stress on sarin levels.

Hoffman, Jerald L. PhD. Mustard Gas: Detoxification by Methylation And Retrospective Analysis of Exposure. University of Louisville, KY. This article discusses possible ways to protect US military personnel and civilians from exposure to mustard gas during destruction of mustard gas and other chemical weapons.

Karlix, Janet L. et al. The Immunomodulatory Effects of The Chemicals Used During The Gulf War. University of Fl. Study done to determine if exposure to Perm, DEET, or PB has any effects on the immune systems of soldiers that were exposed to these particular chemicals during the Gulf War.

Kisby, Glen E. et al. A Novel and Sensitive Method for Detecting Mustard-Induced DNA Adducts. Portland Environmental Health Research Center. Study done to determine if nitrogen and sulfur mustards have a neurotoxic effect on animals and humans when exposed to large concentrations.

Ottenweller, J.E. et al. Persistent Changes in Physiology and Behavior After Pyridostigmine in Rats With Low BuCHE. New Jersey Medical School. Discusses the possibility that levels of BuCHE may effect the development of illness in relation to PB exposure. www.umdnj.edu/~gsbs/neur/otte

Overstreet, DH et al. Failure of Pyridostigmine Pretreatment to Protect Against The Effects of Chlorpyrifos. University of North Carolina, Chapel Hill. Study done on rats to determine if the administration of PB prior to exposure to chemical agents may make certain Individuals more sensitive to these agents.

Van Haaren, F. et al. The Effects of Pyridostigmine Bromide, Permethrin and DEET Alone, or in Combination, On Fixed-Ratio and Fixed-Interval Behavior In Male Sprague-Dawley Rats. University of Fl. Experiment done to evaluate the behavioral effects of small doses of PB, PERM and DEET.

Wilson, Barry W et al. Finger Stick Based Assays of Blood Cholinesterase Levels. University of California, Davis. Discusses the operating procedure for collecting reliable blood samples for monitoring of exposure to chemical warfare and agricultural chemicals.

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