GulfLINK banner
Site Map | Search | Contact Us
LIBRARY
  Overview
Case Narratives
Environmental Exposure Reports
Information Papers
RAND Reports
NEWS ARCHIVE
  Overview
Press Releases
Speeches
HELP FOR VETERANS
  Overview
Medical Information
Medals
The 1990-1991 Gulf War Story
Related Sites
FAQS
  Overview
Depleted Uranium
Khamisiyah
Pyridostigmine Bromide

Meirleir D, et al. A 37 kDa 2-5A Binding Protein as a Potential Biochemical Marker for Chronic Fatigue Syndrome. American Journal of Medicine 2000; 108: 99-105.

The hypothesis of this study is that there develops a problem with the regulation of the antiviral response, resulting in chronic fatigue syndrome (CFS). There is no specific test for this disease of unknown cause that has no effective treatment. Extracts from peripheral blood mononuclear cells were analyzed for 2-5A dependent binding proteins. A heavier (80-kDa) 2-5A binding protein was present in all individuals. A lighter (37 kDa) 2-5A binding protein was present in 50/57 (88%) patients with CFS, 9/28 (32%) in healthy controls, 2/14 (14%) in those with depression and 4/11 (38%) in those with fibromyalgia. The authors conclude this 37 kDa 2-5A binding protein may be a useful biomarker for CFS. The biological significance of these 2-5A binding proteins in patients with CFS is unknown. The 32% positive rate in healthy people shows the limits of specificity of the test.

Return to Medical Research and Publications Defining Illnesses

DHA Address: 7700 Arlington Boulevard | Suite 5101 | Falls Church, VA | 22042-5101

Some documents are presented in Portable Document Format (PDF). A PDF reader is required for viewing:

Download a PDF Reader or learn more about PDFs.