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Subject: PYRIDOSTIGMINE BROMINE PRETREATMENT FOR NERVE AGENTS            

Unit: VAR. BUMED  

Parent Organization: BUMED       

Box ID: BX303817

Folder Title: usns comfort tah 20 1-14 feb 91                                                                 

Document Number:          1

Folder SEQ  #:         21



  UNCLASSIFIED
                      ,7,0.3 MMBB008-39
                      ION 001 OF.00
        @,@.6ECT
                SUBJ PYRIDOSTIGMINE:BROM                                          AGENTS@.
                MSGID/GENADMIN/CGMSCLANT
                REFtA/DTC/NAVMED P-5041//
                AMPN/REF A PROVIDES GUIDANCE ON.,THF, USE OF..PYRIDOSTIGMINE BROMIDE                   AS
                .A PRETREATMENT FOR NERVE AGENTS//
                REF/BIRMG/BUMED/18140OZAUG90/NDTAL//
                AMPN/REF'B PROVIDES SUMMARY,OF.APPLICATION DOCTRINE               PUBLISHED      IN
                REF A//
                              -INST 3
            Z   aREF/C/COMSC            400.2/1
                AMPN/REF C PROVIDES GUIDANCE ON CBR@D            MATERIAL'-JCONDITIO ZIOF
                READINESS//
                    /D/RMG/CDMSC/,031836Z'@T            NLITAL/I
                REF
                                                    ..go/                 ...
                @AMP/RFF.D PROVIDE      REQUISITI iN(i DATA      ANI) REQUIREMENT     CALCVLATION//
                RMKS/1. NERVE AGENT PYRTDWTIGMINE PRE-TREATMEW TABLET SET (NAAP)
                -PROVIDES PROTECTION FOR ENZYMES IN THE BODY THAT ARE TARGETED BY
                NERVE AGENT (NA).       IT IS AN ANTIDOTE ENHANCER,          THOUGH IT DOES NOT
                PROVIDE PROTECTION BY ITSELF, PYRIDOSTIGMINE SIGNIFICANTLY ENHA
            s   THE EFFICIENCY OF NERVE AGENT ANTIDOTES WITHIN ONE TO THREE HOU
                AFTER ADMINISTRATION. MAXIMUK BF-NUFIT DEVELOPS              WITH TIME AND I!
                REACHED WHEN THE SECONJ TABLET.I$ TAKEN WITHIN EIGHT (8) HOURS.
                2. REF A PROVIDES DIRECTION ON USE'OF NAPP TABLET SET IN A CBR@
                POSTCRE. IN LIGHT OF POSSIBLF-,NC)N-@IPT,GF'REF A. REF B PROM
                ED A SUMMARY OF DIRECTION GIVEX:;U RF-F.A. REQUESTS FOR COPIES OF REF,
                A SHOULD BE D RECTED TO         CRIG.:
EATMENT
                PYRIDOSTIGKINE BROMIDE IS-EXCERTFA@FROM REF'B4
                A. WHEN USED WITH THE NA ANTIDOTE-ATROPINE AND 2-PA14 r-HL, SUBJ
                PRETREATMENT ENHANCES SURVIVABILITY!GF,NFT AFFECTED CASUALTIES.
                BENEFITS DERIVED FROM PRETREATMEUT'OCCUR IN NA CASUALTIES'WHO HAVE
                BEEN TREATED BY SELF-AID/BUDDY-AID,AT TIME OF@F-XPOSURE WITH
                                                        "WHO@HAVE TAKEN PRETREATMENT MEDICA-
                ATROPINE/2-PAM CJIL ANTIDOTE AND
                TION WITHIN EIGHT       (8) HOURS'LBEFORE    EXPOSURE.'@.THIS REGIMEN REDUCES
                THE SEVERITY OF NA      SYMPTO@ISHORTENS DURATION OF TREATMENT AND
                INCREASES SURVIVAL      RATE OF NA.C@TIES.
                B. CAUTIONARY NOT       : .00 NOT-AT                                          TO A
                                        E               TEMPT-TO GIVE PYRIDQSrlGMINE
                CASUALTY WITH NA SYMPTOMS.,'
                -C. PRINCIPLES DP USES FOR.'THE GREMES-T EFFECTP               ONE PYFTIDOSTISMINE
                                                                           CONTINUOUS BASIS BEFORE
                TABLET SHOULD BE TAKEN EVERY EI@@HOURS ON                A'
                AN-AA ATTACK UNTIL ORDERS -ARE'ISSUED TA-DISCONTINUE THE MEDICATION.
                -SHIP'S MASTERS SHOULD EVALUATE.'THE'CONTINUING THREAT LEVEL IF NO
                ATTACK HAS OCCURRED AFTER ?2 HOURS:y@,'COMMENCING.PYRIDOSTIGMINE
                TREATMENT.
                D. DOCTRINET EACH        30 MG,TPS;I$.TAKEN       BY@MOUTH,.WITH WATER, EVERY
                EIGHT HOURS AS DIRECTED.                DOSE '-IS MISSED -Dt) NOT ATTEMPT TO
                QOUBLE UP TO MAKE UP THE MISSED DOSAGE--START!'A(3AIN WITH ONE TABLET,'
                EVERY'EIGHT HOURS. CAUTION:".TAKING MORE@             .THAN ONE TABLET AT A TIME'
                DOES NOT PROVIDE ADDITIONAL PROTECTION. -IN FACT, IT MAY BE MORE
ENT EXPOSURE,TO NA. WHEN THE DECISION
                IS MADE* BY THE MASTERV TO ADMINISTER            PYRIDOSTIGMINE IT SHOULD BE










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Document 2 f:/Week-38/BX303817/usns comfort tah 20 1-14 feb 91/pyridostigmine bromine pretreatment for nerve ag:1122961638216
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-38
Box ID = BX303817
Unit = VAR. BUMED
Parent Organization = BUMED
Folder Title = usns comfort tah 20 1-14 feb 91
Folder Seq # = 21
Subject = PYRIDOSTIGMINE BROMINE PRETREATMENT FOR NERVE AG
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 22-NOV-1996