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FM USC1NCC~NT~~CCSI3//                                  To,$.
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RHIIMD~/C~ I K~F REflR~/9B~/                            -~
INFO RUCJ~CC/USCENTCOM FE~R tvI~CnILL ~FB FL/~CCJ~X~~ o~          _____
BT                                                      Pi~s             --
UNCLAS
MINIMIZE CONSIDERED                                               -~
OPER/DESERT STORM//                                     ~~C~      ____
MS~ID/SYS~ RRM/USCENTCOM CCSS//               PRETREATMEi~~~
AMPN/SUBJECTo   NERVE ASENT PYRIflOSTISMINE
RMKS/ls   PRIMARY PROTECTION ASAINST CHEMICAL WEAPONS Is AFFORDED BY
PROPER WEAR OF THE CHEMICAL PROTECTIVE MASK AND CHEMICAL PROTECTIVE
OVERSARMENT (CPOS)a
2.   NERVE ASENT PYRIDOSTISMINE PRETREATMENT (NAPP) IS TO BE
INITIATED, UPON DIRECTION OF UNIT COMMANDERS, BASED ON THE THREAT        t
OF CHEMICAL ABENT EXPOSURE.   NAPP BY ITSELF DOES NOT PROVZflE ANY
PROTECTION ASAINST NERVE ASENT.   TAKEN Ag DIRECTED PRIOR TO NERVE
ASENT EXPOSURE, RESULTS O~ RESEARCH STUDIES IN ANIMALS INDICATE
THAT PYRIDOSTISMINE SREATLY ENHANCES THE EFFICACY OF THE MARK I
NERVE ASENT ANTIDOTE KIT AND CONVULSANT ANTIDOTE NERVE ASENT (CANA).


PAGE ~2 RHIPAAA34l4 UNCLAS
3.   MANY YEARS OF USE IN HUMANS FOR WON-MILITARY PURPOSES INDICATES
THAT PYRIDOSTISMINE IS SAFE AND FREE FROM DEBILITATING SIDE EFFECTS
IF USED AS RECOMMENDED.   IT IS NOT AN lrEXPERIMENTALfl DRUG.   DOSASE
Is ONE (1) 35 MS TABLET EVERY EISHT (S) HOURS.      IF A DOSE IS MISSED,
DO NOT - REPEAT DO NOT1 TAKE TWO TABLETS AT ONCE - MERELY START
AGAIN WITH ONE TABLET EVERY EIGHT HOURS. TAKING MORE THAN ONE TABLET
AT A TIME DOES NOT PROVIDE ANY ADDITIONAL PROTECTION AND MAY BE
HAZARDOUS
4.   THE CHEMICAL THREAT, AND NEED TO CONTINUE NAPP1 SHOULD BE
REEYALUATED EVERY THREE DAYS AT A MINIMUM.      THERE ARE NO
CONTRAINDICATIONS TO REPEATED STARTS AND STOPS OF NAPP
ADMINISTRATION, BUT DECISION TO DO SO SHOULD BE BASED ON ThREAT
ASSESSMENT AND TACTICAL SIThATION.    ADMINISTRATION BEYOND ~1 DAYS
IS NOT RECOMMENDED WITHOUT A THOROUGH EVALUATION OF ThE SITUATION.
5.   POC AT USCENTOOM CCSS IS            TAC 3~B963~7~9~ COMMERCIAL      b-6
~1l-9S6-t-478-4466 EXT 1t~.//
BT
#3414


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