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                           THIS DOCUMENT MAY BE RELEASED IN ENTIRETY


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                         Z)K~~I~ZI~K)K~II~~~~S~~III~IzII~)kXZZ~IXX(I~J

   R~~UZYUW RHIP~~~2433 ()C~717O1-UUUU--RHIlJF~~ RUE)CH~~ RUDOH~~ RUE~E)Wfl
   RUEK~iCS RUEORE)E
   ZNR UUUUU
   R 071322Z J~N 91
   FM USCINCCENT//CCSG//
   TO RUE)CH~~/COMUS~RCENT M4iN//~G//
   RUDOH~~/COMtJSN~VLOGSuPFOR/ /N9//
   RHIUF~~/tJSCENT~F FWD HO-S ELEMENT//SG//
   INFO RUEKJCS/JCS W~SHINGTON DC//t14-LRC//
   RUE~DWD/HO D~ w~SHINGTON DC//D~%:G-~X//
   RUEORDE/CDR US~MRDC FT DETRICI::: MD/~
   BT
   UNCL~S
   OPER/DESERT SHIELD//
   MSOID/SYS. RRM/USCENTCOM CCSG//
   ~MPN/SlJBJECT    INVESTIG4TION~L NEW E)RLlG ~V~IL.~BILITY//
   RMKS/1.  TWO INVESTIO~TION~L NEW DRUGS (IND) SPONSORED BY THE US
   ~RMY MEDIC~L RESE~RCH ~ND DEVEL.OPKENT COMM~ND (US4MRDC} ~RE
   ~V~IL~BLE FOR SPECIFIC ~ND LIMITED INDIC~TIONS.   THESE TWO
   DRUGS ~RE CENTOXIN (~LSO KNOWN 45 H4-14 OR ~~9 4NTIBODY) 4Nfl
   RIB4VIRIN.   THREE PROTOCOLS H4VE BEEN 4PPROVED FOR THE
   EMERGENCY USE OF THESE DRUGS IN THE DESERT SHIEt~D 4RE4 OF
   RESPONSIBILITY (4OR) BY THE US4MRDC, THE FOOD 4ND DRUG
   4DMINISTR4TION (FD4)j 4ND THE M4NtJF4CTliRING COMP4NIES.
~~ 2.  CENTOXIN:    THIS INTR4YENOUSLY 4DMINISTERED DRUG 15 4 HUM4N
   tOM 4NTIBOflY R4ISED 4G4INST 4 MlJT4NT E COLt STR4IN (~5) WHOSE
   EXPOSED LIPOPOLYS4CC4RIDE (LPS OR ENDOTOXIN) CONT4INS 4 COMMON


   P4GE O2 RH1P444\\\\ UNCL4S
   GR4M NEG4TIVE ENDOTOXIN 4NTIGEN.   THE PRODUCT H45 BEEN
   PRODUCED IN INDUSTRI4L ~tJ4NTITIES FROM 4 MURINE/HUM4N
   HYBRIDOM4 LINE 4ND IS VERY EXPENSIVE (S2500 PER VI4L).
   INDIC4TION FOR USE IS THE GR4M NEG4TIVE SEPTIC SHOCK SYNtIROME
   STRICT 4DHERENCE TO THE PROTOCOL IS RE(~~UIRED.
   3.  RIB4VIRIN:   RIB4VIRIN IS 4 SYNTHETIC NUCLEOSIDE TH4T IN
   E4Rt.Y STUDIES H45 SHOWN EFFIC4CY 4G4INST BUNY4VIRUS
   HEMORRH4GIC FEVERS (CRIME4N CONGO HEMORRH4GIC FEVER,   RIFT
   V4LLEY FEVER~ 4N13 HEMORRH4OIC FEVER WITH REN4L SYNDROME).
   CCHF IS KNOWN TO EXIST IN THE THE4TER OF OPER4TIONS WITH 4N
   OUTBRE4K IN THE 80'S IN B4GHD4D, 4 C4SE IN ~4T4R IN THE SO'S,
   4ND SEVER4L C4SES ON THE WEST CO4ST OF S4tJDI 4R4B14 IN 1990.
   4 HOSPIT4L ~4SED SEROSURYEY IN KUW4IT FROM 1979 TO 19B2 SHOWED
   4% TO BE POSITIVE FOR CCHF. TWO PROTOCOLS H4VE BEEN 4PPROVED
   FOR THIS ENTJTY.   THE FIRST IS FOR INTR4VENOlJS THER4PY OF
   OVERT, CLINIC4L C4SES OF HEMORRH4GIC FEVER.   THE SECOND IS FOR
   OR4L (4ND IN SOME INST4NCES INTR4VENOUS) PROPHYL4XIS OF HE4LTH
   C4RE WORKERS EXPOSED TO 4N OVERT C4SE OF- HEMORRH4GIC FEVER.
   MOST ~UTBRE4k'S INCLUDE NOSOCOMI4L TR4NSMISSION FROM THE INDEX
(  C4SE TO HE4LTH C4RE PROVIDERS WITH 4 30% F4T4LITY R4TE (R4NGE

                         II~~ILIXIX~X~X~X)K~~)K~~)K~I1KXX(IIX~IIII~
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