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File: 102496_sep96_decls3_0009.txt
Subject: MEDICAL BRIEF SUMMARIES
Unit: OTSG
Parent Organization: HSC
Box ID: BX003202
Folder Title: BRIEFING TO BG BLANCK BOTULINUM TOXOID
Document Number: 1
Folder SEQ #: 12
ANTI-BOTULINUM EQUINE F(ab") 2
First Horses delivered 14 December 1990
52 new horses available - 15 December
Draft Sow for plasma processing corrtract - 16 Deoember
Physicals completed; 6 horses immunized - 17 December
12 Horses immunized - 21 Demmt)er
immunize 24 horses - 7-9 January 1991
gmlmmunize 6 horses - 10 - 22 January
Contract award for plasma processing - 15 Febnjary
First bleeds o( lst group of horses - 18 Februaty
Initiate plasma processing - late February
Initiate bleeds of all horses - 1 1 March
Plasma processing (2 wks I batch) - April - May
T@ first lots / IND - May - June
Product available -June 1991
December January February March April May June
ISSUES:
o Rapid immunization - risks unknown in terms of product characteristics and availability
o Product formulation different from IND submission
- Immunization of additional horses if current animals fail to respond - impact on antigen
LU availability for immunization and time to product
co
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Document 9 f:/Week-36/BX003202/BRIEFING TO BG BLANCK BOTULINUM TOXOID/medical brief summaries:1011961539064
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003202
Unit = OTSG
Parent Organization = HSC
Folder Title = BRIEFING TO BG BLANCK BOTULINUM TOXOID
Folder Seq # = 12
Subject = MEDICAL BRIEF SUMMARIES
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 11-OCT-1996