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Subject: RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALATION ANTHRAX    

Unit: OTSG        

Parent Organization: HSC         

Box ID: BX003203

Folder Title: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX                             

Document Number:          1

Folder SEQ  #:          5


                                                 UNCLAI§§TIED


                  ILTZ    Z POR MMZIIZOTXCS IN no*XV=Zg XOHZXIT






              Inhalation anthrax is an @est uniformly fatal disease.
          *arianea with this syndrome in humans in limited; what

          information is available indicates that once clearout symptoms

          and si@ emerge, even 'Massive dome* of antibiotics are futile.

          There is no question that the beat approach to the threat of

          inhalation azthrax is active immunization prior to exposure,

          possibly coupled with use of antibiotics after exposure. In the

          abmance of widely available vaccine, however, administration of

          appropiats antibiotics prior to exposure, or in the immediate

          post-exposure period, offers a secondary option which could
          improve survival, particularly if antibiotic use is combined with
          immunization in the post-exposure period. Rationale for this
          position is based on the following facts: a) the J4 vitro
          sensitivity of Bacillus anthracis to c @ ain antibiotics b) the

          demonstrated utility of antibiotics in treatment of

          anthrax; and (probably moat importantly) c) results of
          experiments in non-h=an primates which indicate clearly that

          antibiotics administered after wtosura to lethal challangq with
          anthrax spares will prevent disease while they are being given
          (and may reduce mortality it continued for a sufficient period of

          time),                 DECLASSIFIED
                                 ON: 31 OCT 96
                                 BY: SEC ARMY (DAMH) UNDER SEC 3.4 EO 12958
               As Za vitro sensitivity:




                                    it%rnnrt
                                    7
                                    ..inW-E I

                                     UNCLASSIFIED

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Document 8 f:/Week-36/BX003203/RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX/rationale antibiotics prophylaxis against inhala:11089615091429
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX
Folder Seq # = 5
Subject = RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALA
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 08-NOV-1996