RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALATION ANTHRAX

File: 120396_sep96_decls28_0003.txt
Page: 0003
Total Pages: 8

Subject: RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALATION ANTHRAX    

Unit: OTSG        

Parent Organization: HSC         

Box ID: BX003203

Folder Title: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX                             

Document Number:          1

Folder SEQ  #:          5




                                                   UNCLASSIFIED
        C=ed with appropriate antibiotic therapy, particularly if
        recognized early and treated early in the disease course (3). A
        variety of antibiotic& have been used with success, but@
        penicillin generally provides the most rapid sterilization and
        resolution of the lesion.



             Cl NOn-hUman primate experiments

             The offset of antibiotics on the course of i @ lation
        anthrax has been most extensively examined in non-h=an primate

        models of the disease. Several studies conducted in the 1950a

        and 19$os demonstrated that the course of inhalation anthrax
        could be modified through antibiotic use after exposure to lethal
        domas of spores by inhalation (4,5,S). These experiments are
        notable for the following points: 1. antibiotic therapy alone

        seems capable of prolonging the time to death, Animals seem to
        survive as long as the drug in being actively administered, but
        die at varying intervals after its discontinuation. 2.
        antibiotics combined with @am* form of immunological
        intervention--active (i.e., vaccination) or passive (i.e., immune
        serum)--in the post-@osure period offered the beat chance of

        success.

             A recent sxperiment conducted at USMMIID seems to confirm
        these previous oba@ations (7). This study indicated that; 1.
        'Under the conditions of the study, penicillin, doxycycliner and
        cipraflaxacin given for a 30 day period improved survival over no
        antibiotic treatment, 2. Deaths occurred, as predicted, after


                                         3

                              ICEI!llcl      -
                              %)LUIXL I

                                UNCLASSIFIED

Document 8 f:/Week-36/BX003203/RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX/rationale antibiotics prophylaxis against inhala:11089615091429
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX
Folder Seq # = 5
Subject = RATIONALE ANTIBIOTICS PROPHYLAXIS AGAINST INHALA
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 08-NOV-1996