RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION

File: 970107_sep96_decls11_0003.txt
Page: 0003
Total Pages: 9

Subject: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: FAX   RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2                     

Document Number:    1160001

Folder Seq  #:    1160000











                 Inhalation anthrax is an almost uniformly fatal disease.
             14*rianca with this syndrome in humans is limited; what

             information in available indicates that once cloarout symptoms

             and signs emerge, even massive doses of antibiotics are futile.

             There is no question that the bast approach to the threat of

             i@lation anthrax is activt i=unization prior to @osurs,

             possibly coupled with use of antibiotics after exposure, In the

             absence of widely available vaccine, however, administration of

             appropiata antibiotics prior to exposure, or in tha immediate

             p*st-exposuro period, offers a secondary option which could
             improve survival, particularly if antibiotic use is combined with
             immunization in the post-wtasuro period. Rationale for this
             position is based on the following f&c-.st a) the JA vitro
             sensitivity of Bacillus anthracia to ctrtain antiblotioel D) the

             demonstrated utility of antibiotics in treatment of ogtantaus

             anthrax, and (probably most importantly) c) results of

             experiments in non-h=an primates which indicate clearly that

             antibiotics administered after exposure to lethal challenge with
             anthrax sports will prevent disease while they are being given
             (and may reduce mortality if continued for a sufficient period of

             time).



                 A; ;a vitro sensitivity:

Document 9 f:/Week-36/BX003203/FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2/rationale for antibiotics in prophylaxis against:01029715471112
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2
Folder Seq # = 1160000
Subject = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST
Document Seq # = 1160001
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997