RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION

File: 970107_sep96_decls11_0004.txt
Page: 0004
Total Pages: 9

Subject: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: FAX   RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2                     

Document Number:    1160001

Folder Seq  #:    1160000





                The vast zajority of anthrax strains are sensitive J&
           to penicillin. Historically, this drug has bean considered the
           "tr*atmant of choictit fo.r all forms of anthrax; tetracycline,

           orythromycinj and chloramphanicol have boon recommended in
           p@icillin-allargic patients. Rare panicillin-resistant *train&
           *XiSt naturally, however, and one has boon recovered from a fatal

           human case. In addition, it is not difficult to induca

           resistance to both penicillin and tetracycline through laboratory
           manipulation of anthrax bacilli. ciprofloxacin is a relatively
           now antibiotic with a novel mach @ am of action (DNA gyrase

           inhibitor). To datat all strains of anthrax tested have proven
           quite sensitive (1,2). Because this in a relatively new drug,

           and bscauss of its unusual mechanism of action, it is unlikely

           that resistance harm been "engineered" at this time. Therefore,
           cipratioxacin, a drug with few recognized side effects, a
           convenient oral doming schedule (twice daily), and sxcallent
           activity both Ja vitro and in @     offers a good option for

           antibiotic use in countering possible infection with this

           organism. Many of those same arguments can be made for

           doxycyclina as well; however, the m*thoda for engineering

           resistance to tetracyclines are simple and readily available in

           the open literature. This combined with recognized

           Pho@rq#4n*itivity rske doxyryclina n rArn?liiAry npt-inn,



                a: Utility of antibiotic& in cutaneous anthrax

                Publioh*d series confirm that cutaneous anthrax is readily


                                            2

Document 9 f:/Week-36/BX003203/FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2/rationale for antibiotics in prophylaxis against:01029715471112
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2
Folder Seq # = 1160000
Subject = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST
Document Seq # = 1160001
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997