RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION

File: 970107_sep96_decls11_0006.txt
Page: 0006
Total Pages: 9

Subject: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: FAX   RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2                     

Document Number:    1160001

Folder Seq  #:    1160000





            antibatica war* discontinued, 3. Doxycyclina and ciprotloxacin
            may have offered some advantage over penicillin in this
            (inhalation anthrax) setting, Ind 4. combined antibiotics and
            vaccination in the post- @ asurs period resulted in the beat

            survival.



                 a simplified review of pathogenesis coupled with speculation
            about mechanism of antibiotic activity might shod light on the
            observed findings. Anthrax organisms are most effectively

            delivered by i@lation in the form of sports. Inhalation of
            these spores results in savdinq of terminal rtapiratory
            bronchioles. Spores than are phaqooytosed by alvsolar
            macrophages and transported to lymphatic organs in the chest
            (pulmonary and madiastinal lymph nodes) and elsewhere. There,
            the spores germinate, becoming "vegetative'' organisms which
            release toxins and exert adverse physiologic *ffoots. With
            continued replication of these "vegetative'' baoillit increasingly
            larger numbers of organisms and their toxins circlalats. 'Finally,
            the host is overwhelmed and de&= ansues. with administration of

            appropriate antibiotics, vegetative forms (= spores) are
            killed. In some cases, this may be adequate for a "cure.,,     In
            many others, however, additional spores probably remain dormant
            until antibiotics are discontinued. In these individuals,
            residual spores then garminate, and the r&plioative process
            begins anaw. Thsoratically, these persons could remain on
            antibiotic s for prolonged periods, and survive. In practice,


                                             4

Document 9 f:/Week-36/BX003203/FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2/rationale for antibiotics in prophylaxis against:01029715471112
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2
Folder Seq # = 1160000
Subject = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST
Document Seq # = 1160001
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997