Document Page: First | Prev | Next | All | Image | This Release | Search

Subject: RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION     

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003203

Folder Title: FAX   RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2                     

Document Number:    1160001

Folder Seq  #:    1160000





           C=ad with appropriate antibiotic therapy, particularly if
           recognized early and treated early in @a disease course (3). A

           variety of antibiotics have been used with success, but
           penicillin generally provides the most rapid sterilization and

           resolution of the lasion.



                C: Non-human primate experiments

                The Stf*ot of antibiotics on the course of inhalation

           anthrax has boon most extensively oxamined in nonhuman primate

           models of the dissass. several studios conducted in the 1050s

           and 19$os demonstrated that the course of inhalation anthrax

           could be modified through antibiotic use after exposure to lethal
           dosse of spores by inhalation (4tSl5). These experiments &re

           notable for the following points: 1. antibiotic therapy alone

           seems capable of prolonging the time to death. Animals seem to
           survive as long as the drug in being actively adrainisterod, but
           dia at varying intervals after its discontinuation. 2.

           antibiotics cabinad with see* form of immunological

           intervention--active (i.e., vaccination) or passive (i.o., immune
           serum)--in the post-exposuro period offered the best chance of

           Success,

                A recent experiment conducted at USMMIID seems to confirm
           these previous oba@ations (7). This study indicated that; 1.
           TJnder the conditions of the study, penicillin, doxyoyalinat and
           ciprotloxacin given for a 30 day period improved survival over no
           antibiotic troa=mnt, 2. Death$ occurred, an predicted, after


                                           3

Document Page: First | Prev | Next | All | Image | This Release | Search

Document 9 f:/Week-36/BX003203/FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2/rationale for antibiotics in prophylaxis against:01029715471112
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003203
Unit = OTSG
Parent Organization = HSC
Folder Title = FAX RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST INHALATION ANTHRAX-2
Folder Seq # = 1160000
Subject = RATIONALE FOR ANTIBIOTICS IN PROPHYLAXIS AGAINST
Document Seq # = 1160001
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997