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File: 970107_sep96_decls33_0004.txt
Subject: PREVENTION OF HEPATITIS A IN SOLDIERS
Unit: OTSG
Parent Organization: HSC
Box ID: BX003205
Folder Title: HEPATITIS A - VACCINES
Document Number: 1
Folder Seq #: 62
Percent with neutralizing antibody
Group Received Nunber Month 0 Month I Month 6 Month 8
1 HAV Needle 10 0 50 90 100
2 HAV Jetcjun 10 0 60 90 100
Side effects
Following Dose 1
Am.
Group NLn Feverish Headache Malaise Nausea vomiting xyatgia Swollen Red Sore
Needle 91 3% Is 4 7 1 15 3 2 40
JetG@ 96 6 9 5 I 0 10 19 22 43
...............................................................................
Following Dose 2
Needle 72 0% 6 0 3 0 10 13 0 19
JetGm 73 4 3 3 1 0 10 10 15 30
...............................................................................
Following Dose 3
Needle 60 3% 3 2 0 0 8 5 5 22
JetGm 70 1 1 0 0 0 7 16 19 20
(3) Conclusions
(a) Three doses of this preparation provides a
high level of antibody to nearly all recipients.
(b) The vaccine is safe and well tolerated. It
would minimally disrupt unit acitivities.
b. Rapid immunization schedules using higher potency
vaccine.
Selected data from studies carried out in Europe are
presented here. These data indicate that the vaccine
would stimulate antibody in all recipients, and that
antibody would persist at least 9 months. One
limitation of this data is that it is based on the
results of an ELISA test rather than a neutralizing
antibody test.
(1) Results
Percent of initially non-immune volunteers with antibody
following administration of IIM-175 vaccine. The geometric mean
titer is shown in the line below.
Schedule < --- Time of Sample (days following first dose) --- >
(Days) 14 30 60 120 180 270
0, 14 Percent 44% 100% 100% 100% 100% 100%
GMT 259 596 418 350 243 181
3
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Document 7 f:/Week-36/BX003205/HEPATITIS A - VACCINES/prevention of hepatitis a in soldiers:01029715472734
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003205
Unit = OTSG
Parent Organization = HSC
Folder Title = HEPATITIS A - VACCINES
Folder Seq # = 62
Subject = PREVENTION OF HEPATITIS A IN SOLDIERS
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997