PREVENTION OF HEPATITIS A IN SOLDIERS

File: 970107_sep96_decls33_0005.txt
Page: 0005
Total Pages: 7

Subject: PREVENTION OF HEPATITIS A IN SOLDIERS                           

Unit: OTSG        

Parent Organization: HSC         

Box  ID: BX003205

Folder Title: HEPATITIS A - VACCINES                                                                          

Document Number:          1

Folder Seq  #:         62


                            Sym, ' oms reported following 720 EU vaccine:

                                     SVMT)tom    No.  PercenL
                                     Fever       289    2.1
                                     Headache    289   13.8
                                     Malaise            9.7

                            (2) Conclusions

                               (a) The higher potency vaccine appears to provide
                               all recipients with antibody following a 0, 14 day
                               schedule.

                               (b) Antibody persists for at least 9 months.

                               (e) The comparability of this data to data
                               collected at Ft. Campbell is unknown, since
                               different populations and differents assays were
                               used.


                               (d) Assessment of this schedule in U. S. Soldiers
                               should be carried out immediately.

                     3. Availability of vaccine

                     The company provided the following figures on 5 December
                     1990.

                               Availability of SKB HAV vaccine (HAVRIX)*

                     Number of Available         Soldiers
                     doses       Date            Protected  Cost
                       80,000     15 DEC 90      40,000     $0.8M
                       80,000     30 JAN 91      40,000     $0.8m
                     500,000       1 MAY 91      250,000    $5.OM
                                                 330,000    $6.8

                       Availability subject to passing final safety tests.

                     Thus, a large portion of the force in Saudi Arabia could be
                     immunized against hepatitis A for approximately $ 7
                     million.

                     4. WRAIR research plans

dules with the
                     higher potency vaccine in soldiers is required. A study is
                     planned to be carried out at Schofield Barracks in February
                     1991. The 251D Division Surgeon, LTC Steve Jones, had
                     provided substantial support before this became an urgent
                     matter. We would expect continued excellent support.

                     5. Other considerations

                        a. Alternatives

                            (1) Immune serum globulin

                            ISG is considerably cheaper. Disadvantages include
                            its limited supply as a licensed product and the


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Document 7 f:/Week-36/BX003205/HEPATITIS A - VACCINES/prevention of hepatitis a in soldiers:01029715472734
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003205
Unit = OTSG
Parent Organization = HSC
Folder Title = HEPATITIS A - VACCINES
Folder Seq # = 62
Subject = PREVENTION OF HEPATITIS A IN SOLDIERS
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997