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File: 970107_sep96_decls61_0004.txt
Subject: COVER SHEET FOR DOCUMENT TRANSMISSION
Unit: OTSG
Parent Organization: HSC
Box ID: BX003205
Folder Title: 4TH USAMRDC LEISHMANIASIS VARIOUS LEVELS
Document Number: 1
Folder Seq #: 12
Percent with neutralizing antibody
Group Received Number Month 0 Month 1 Month 6 Month 8
1 HAV Needle 10 0 50 90 100
2 IIAV Jetcjun 10 0 60 90 100
Side effects
Following Dose I
Am
Group Nun Feverish Headache Malaise wausea Ymiting myatgia SwoLten Red Sore
Needle 91 3% is 4 7 1 15 3 2 40
JetG@ 96 6 9 5 1 0 10 19 22 43
..............................................................................
Following Dose 2
Needle 72 0% 6 0 3 0 10 13 0 19
JetG@ 73 4 3 3 1 0 10 10 15 30
...............................................................................
Following Dose 3
Needle 60 3% 3 2 0 0 a 5 5 22
JetG@ 70 1 i 0 0 0 7 16 19 20
(3) Conclusions
(a) Three doses of this preparation provides a
high level of antibody to nearly all recipients.
(b) The vaccine is safe and well tolerated. It
would minimally disrupt unit acitivities.
b. Rapid immunization schedules using higher potency
vaccine.
Selected data from studies carried out in Europe are
presented here. These data indicate that the vaccine
would stimulate antibody in all recipients, and that
antibody would persist at least 9 months. One
limitation of this data is that it is based on the
results of an ELISA test rather than a neutralizing
antibody test.
(1) Results
Percent of initially non-immune volunteers with antibody
following administration of HM-175 vaccine. The geometric mean
titer is shown in the line below.
Schedule < --- Time of Sample (days following first dose) --- >
(Days) 14 30 60 120 180 270
0, 14 Percent 44% 100% 100% 100% 100% 100%
GMT 259 596 418 350 243 181
3
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Document 7 f:/Week-36/BX003205/4TH USAMRDC LEISHMANIASIS VARIOUS LEVELS/cover sheet for document transmission:01029715474762
Control Fields 17
File Room = sep96_declassified
File Cabinet = Week-36
Box ID = BX003205
Unit = OTSG
Parent Organization = HSC
Folder Title = 4TH USAMRDC LEISHMANIASIS VARIOUS LEVELS
Folder Seq # = 12
Subject = COVER SHEET FOR DOCUMENT TRANSMISSION
Document Seq # = 1
Document Date =
Scan Date =
Queued for Declassification = 01-JAN-1980
Short Term Referral = 01-JAN-1980
Long Term Referral = 01-JAN-1980
Permanent Referral = 01-JAN-1980
Non-Health Related Document = 01-JAN-1980
Declassified = 02-JAN-1997